DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG9270 and Cftr

DIOPT Version :9

Sequence 1:NP_995741.2 Gene:CG9270 / 35366 FlyBaseID:FBgn0032908 Length:1292 Species:Drosophila melanogaster
Sequence 2:NP_066388.1 Gene:Cftr / 12638 MGIID:88388 Length:1476 Species:Mus musculus


Alignment Length:1496 Identity:410/1496 - (27%)
Similarity:705/1496 - (47%) Gaps:232/1496 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCG 70
            :|.:|.|.|...|.|.|.:..|||.||.:..||.:|:|.|.....|:.|.:|....|..|..|  
Mouse     1 MQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSADSADHLSEKLEREWDREQAS-- 63

  Fly    71 DSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIYG 135
               ||.|.:|..:.:.|.|:....||::.:.|: |:|..|::||.:||.:......:...|...|
Mouse    64 ---KKNPQLIHALRRCFFWRFLFYGILLYLGEV-TKAVQPVLLGRIIASYDPENKVERSIAIYLG 124

  Fly   136 LTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLISNDLG 200
            :.|.|..:...|:.||.:.||..:.|:||.|:.:.||:|.|:||...|...:.||:|:|:||:|.
Mouse   125 IGLCLLFIVRTLLLHPAIFGLHRIGMQMRTAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLN 189

  Fly   201 RFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALR 265
            :||..|...||:|:.||::.:....|:..:..::..|:.:|::.:..|..|.::..:.|.|.|.:
Mouse   190 KFDEGLALAHFIWIAPLQVTLLMGLLWDLLQFSAFCGLGLLIILVIFQAILGKMMVKYRDQRAAK 254

  Fly   266 TDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLSRIAIF 330
            .::|:.:.:|||..|..:|.|.||....::||.||..|:...||..|:|....|.........:|
Mouse   255 INERLVITSEIIDNIYSVKAYCWESAMEKMIENLREVELKMTRKAAYMRFFTSSAFFFSGFFVVF 319

  Fly   331 VSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRSETEAL 395
            :|:|.:.::.| :...:.|:..:|..:||.:|.:.||:.:..:.:....:|:|:.|:.:.|.:.|
Mouse   320 LSVLPYTVING-IVLRKIFTTISFCIVLRMSVTRQFPTAVQIWYDSFGMIRKIQDFLQKQEYKVL 383

  Fly   396 YLKGGQTNKLFE----------GEPLVKLQSFQARWNHDHVE-------------PVLENINISL 437
            ......|..:.|          ||.|.|:|.......|...|             |||:|||:::
Mouse   384 EYNLMTTGIIMENVTAFWEEGFGELLEKVQQSNGDRKHSSDENNVSFSHLCLVGNPVLKNINLNI 448

  Fly   438 SPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMD 502
            ...:::|:.|..||||:||:..|||||....|.:|..|.:|:.||..|:...::::||:||:..|
Mouse   449 EKGEMLAITGSTGSGKTSLLMLILGELEASEGIIKHSGRVSFCSQFSWIMPGTIKENIIFGVSYD 513

  Fly   503 KHRYRNVIRNCALERDF-ELLHGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAV 566
            ::||::|::.|.|::|. :....|.|.:||.|.:||||||||||||||||:.||.||||.|...:
Mouse   514 EYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQRARISLARAVYKDADLYLLDSPFGYL 578

  Fly   567 DTHVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDF-GK 630
            |......:||.|:...:.:|..||||.:::.|..||.|:|:.:|.....||:.|:.....|| .|
Mouse   579 DVFTEEQVFESCVCKLMANKTRILVTSKMEHLRKADKILILHQGSSYFYGTFSELQSLRPDFSSK 643

  Fly   631 LLA-------TEAQ------------EMGDSNQ---------EQVNAEGDSRNDKSTYSRQSSRV 667
            |:.       ||.:            .:.||:.         .|....|:.|  |::.....|.|
Mouse   644 LMGYDTFDQFTEERRSSILTETLRRFSVDDSSAPWSKPKQSFRQTGEVGEKR--KNSILNSFSSV 706

  Fly   668 SRVSVTSVDSSTESILDNERQPAQESR-------SQGKIGL------------------------ 701
            .::|:.   ..|...:|.|....||.|       .||:..|                        
Mouse   707 RKISIV---QKTPLCIDGESDDLQEKRLSLVPDSEQGEAALPRSNMIATGPTFPGRRRQSVLDLM 768

  Fly   702 ----------------------------------------------------------------- 701
                                                                             
Mouse   769 TFTPNSGSSNLQRTRTSIRKISLVPQISLNEVDVYSRRLSQDSTLNITEEINEEDLKECFLDDVI 833

  Fly   702 --------GIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVKNNDSSSSTD------ 752
                    ..|.:||:...|.|:|::   :|:...::......|:.:.:|||..:|..:      
Mouse   834 KIPPVTTWNTYLRYFTLHKGLLLVLI---WCVLVFLVEVAASLFVLWLLKNNPVNSGNNGTKISN 895

  Fly   753 ---------------IYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFH 802
                           .||:.|:...|:..:|.|.|......:.:|..||..|...:....:....
Mouse   896 SSYVVIITSTSFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTIS 960

  Fly   803 ANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLR 867
            ...:|.|||||:.|:..:|:.||..:.|.||:...:.|.|.|:....|:..:.|:...:.|..||
Mouse   961 KLKAGGILNRFSKDIAILDDFLPLTIFDFIQLVFIVIGAIIVVSALQPYIFLATVPGLVVFILLR 1025

  Fly   868 TFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLST 932
            .::|.|::.||:||:..|||:::|...:|.||.|:||...|......:....::|::.::.:|:|
Mouse  1026 AYFLHTAQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLHTANWFMYLAT 1090

  Fly   933 NRAFGYYLDLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTS 997
            .|.|...:|:..|.:.|.||.:|..... :..|..|:::|.||::..|:||.:..|.:.::.|.|
Mouse  1091 LRWFQMRIDMIFVLFFIVVTFISILTTG-EGEGTAGIILTLAMNIMSTLQWAVNSSIDTDSLMRS 1154

  Fly   998 VERVLEYRHLEAEGEFESPDDKKPPMN------------------WPQEGLISAEQLSLRYNPDP 1044
            |.||.::..::.|....:...|:.|..                  ||..|.:..:.|:::|..|.
Mouse  1155 VSRVFKFIDIQTEESMYTQIIKELPREGSSDVLVIKNEHVKKSDIWPSGGEMVVKDLTVKYMDDG 1219

  Fly  1045 KADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRLSYNEGSLVIDNTDILGIGLHDLRSKI 1109
            .|  ||::::|.|.|.:::|::||||:|||:|::|..|:...:|.:.||......:.|.:.|...
Mouse  1220 NA--VLENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIKGDIEIDGVSWNSVTLQEWRKAF 1282

  Fly  1110 SIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQR 1174
            .:|.|:..:||||.|.||||..::.||::|:..:||.||..:.:.|..|...:.:||...|.|.:
Mouse  1283 GVITQKVFIFSGTFRQNLDPNGKWKDEEIWKVADEVGLKSVIEQFPGQLNFTLVDGGYVLSHGHK 1347

  Fly  1175 QLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVL 1239
            ||:||||::|.:.:|:::||.:|::||.|..:|:..:::.|..|||:...||:..::|..|.:|:
Mouse  1348 QLMCLARSVLSKAKIILLDEPSAHLDPITYQVIRRVLKQAFAGCTVILCEHRIEAMLDCQRFLVI 1412

  Fly  1240 DAGTLVEFGSPFELLTQSWSKVFYGMVLQT-------GRSSFEHLLKLAL---------EAHERR 1288
            :...:.::.|...||::  ..:|...:..:       ||.|.:|..:..:         |..|.|
Mouse  1413 EESNVWQYDSLQALLSE--KSIFQQAISSSEKMRFFQGRHSSKHKPRTQITALKEETEEEVQETR 1475

  Fly  1289 L 1289
            |
Mouse  1476 L 1476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9270NP_995741.2 CFTR_protein 6..1257 CDD:273530 401/1446 (28%)
ABC_membrane 92..362 CDD:294371 80/269 (30%)
ABCC_MRP_domain1 412..611 CDD:213217 83/212 (39%)
ABC_membrane 718..981 CDD:294371 71/283 (25%)
ABCC_MRP_domain2 1029..1250 CDD:213211 74/220 (34%)
CftrNP_066388.1 CFTR_protein 1..1464 CDD:273530 406/1482 (27%)
ABC_membrane 85..303 CDD:294371 70/218 (32%)
ABCC_CFTR1 389..670 CDD:213258 98/280 (35%)
CFTR_R 639..844 CDD:291094 24/209 (11%)
Disordered R region. /evidence=ECO:0000250|UniProtKB:P13569 654..826 20/176 (11%)
ABC_membrane 861..1142 CDD:279056 74/281 (26%)
ABCC_CFTR2 1204..1464 CDD:213256 82/263 (31%)
Interaction with GORASP2. /evidence=ECO:0000250|UniProtKB:P13569 1382..1476 19/95 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1446..1476 6/29 (21%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P13569 1474..1476 0/1 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841712
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.850

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