DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC4

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_005836.2	Gene:	ABCC4 / 10257	HGNCID:	55	Length:	1325	Species:	Homo sapiens

Alignment Length:	1322	Identity:	588/1322 - (44%)
Similarity:	838/1322 - (63%)	Gaps:	69/1322 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKLQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEV-R 67
            ::::.||.:.|.:.|.:.|.:..|:...|.|:.||..|:|:.|.|.:::.||::....|..|| |
Human     6 QEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLR 70

  Fly    68 SCGDSPKKEPSIIRVILKVFGWQLFLSGIVVGV---LELGTRATLPLILGALIAEFTRNGNGDGL 129
            :..|:.|  ||:.|.|:|.: |:.:|   |:|:   :|...:...|:.||.:|..|......|.:
Human    71 AENDAQK--PSLTRAIIKCY-WKSYL---VLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSV 129

  Fly   130 ---WAQIYG-----LTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDT 186
               .|..|.     .||||:||..:..:|....|     |::|||:...|||||||||..|:|.|
Human   130 ALNTAYAYATVLTFCTLILAILHHLYFYHVQCAG-----MRLRVAMCHMIYRKALRLSNMAMGKT 189

  Fly   187 TTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFL 251
            ||||:|||:|||:.:||:..:..||||.|||:.:..:..|:.:||::.|.|:.:|::.||:|:..
Human   190 TTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCF 254

  Fly   252 SRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGT 316
            .:|.|.||.:||..||.|:|.|||:|:||::||||.|||.|..||..||:.|:|.|.:.:.:||.
Human   255 GKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGM 319

  Fly   317 LLSFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLR 381
            .|:...:.|:|.:||:...:||:|..:||.|.|.....|..:|.||..||||.:.:.:|.:|::|
Human   320 NLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIR 384

  Fly   382 RIKGFMMRSETEALYLKGGQTNKLF--EGEPLVKLQSFQARWNHDHVEPVLENINISLSPPQLVA 444
            ||:.|::..|.       .|.|:..  :|:.:|.:|.|.|.|:.....|.|:.::.::.|.:|:|
Human   385 RIQTFLLLDEI-------SQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLA 442

  Fly   445 VIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNV 509
            |:||||:|||||:.|:||||....|.:.|.|.|:|.||:||:|:.::|.|||||...:|.||..|
Human   443 VVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKV 507

  Fly   510 IRNCALERDFELLH-GDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRH 573
            |:.|||::|.:||. ||.|.:|:||.:|||||:||::||||||:.||.|||||||||||..|.||
Human   508 IKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRH 572

  Fly   574 LFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQE 638
            |||.|:...|.:|:.||||||||:|:.|..|:|:..||:...|||.|.||||.|||.||..:.:|
Human   573 LFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEE 637

  Fly   639 MGDSNQEQVNAEGDSRN----DKSTYSRQSSRVSRVSVTSVDSSTESILDNERQP---AQESRSQ 696
               |.|..|......||    :.|.:|:||||.|     ..|.:.|| .|.|..|   ::|:||:
Human   638 ---SEQPPVPGTPTLRNRTFSESSVWSQQSSRPS-----LKDGALES-QDTENVPVTLSEENRSE 693

  Fly   697 GKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYW--------VKNNDSSSSTD- 752
            ||:|...|..||.||:.|::.|.:.......|:.....|::||||        |..|...:.|:
Human   694 GKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEK 758

  Fly   753 ------IYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILN 811
                  :.|:||:..|.|:|.:.|:||.|.:.::||..|||.||:.:.:..:.||..||.|||||
Human   759 LDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILN 823

  Fly   812 RFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRD 876
            ||:.|:|.:|::||...||.||..|.:.|::.|.....||..|..:.:.:.|.|||.::|.||||
Human   824 RFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRD 888

  Fly   877 LKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLD 941
            :||||:..|||::||.|::|.||.||||.:|::...:.:|.:||:||..::.||:|:|.|...||
Human   889 VKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLD 953

  Fly   942 LFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRH 1006
            ..|..:||.|...|.......:.||:||.::.|:::.|..||.:|||||:||.|.|||||:||..
Human   954 AICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTD 1018

  Fly  1007 LEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGA 1071
            ||.|..:|.  .|:||..||.||:|..:.::..|:|.  ...|||.|..:|..:||:||||||||
Human  1019 LEKEAPWEY--QKRPPPAWPHEGVIIFDNVNFMYSPG--GPLVLKHLTALIKSQEKVGIVGRTGA 1079

  Fly  1072 GKSSLINALFRLSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADE 1136
            ||||||:||||||..||.:.||......|||||||.|:||||||||||:||:|.|||||.::.||
Human  1080 GKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDE 1144

  Fly  1137 KLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDP 1201
            :||.||:||.||:.:.:||..:::.:||.|||:||||||||||||||||:|:||::|||||||||
Human  1145 ELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDP 1209

  Fly  1202 QTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMV 1266
            :||.|||..||.||..|||||||||||||||||::||||:|.|.|:..|:.|| |:...:||.||
Human  1210 RTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLL-QNKESLFYKMV 1273

  Fly  1267 LQTGRSSFEHLLKLALEAHERR 1288
            .|.|::....|.:.|.:.:.:|
Human  1274 QQLGKAEAAALTETAKQVYFKR 1295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	578/1287 (45%)
		ABC_membrane	92..362	CDD:294371	111/280 (40%)
		ABCC_MRP_domain1	412..611	CDD:213217	105/199 (53%)
		ABC_membrane	718..981	CDD:294371	103/277 (37%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	139/220 (63%)
ABCC4	NP_005836.2	CFTR_protein	11..1269	CDD:273530	579/1289 (45%)
		ABC_membrane	96..365	CDD:294371	109/273 (40%)
		ABCC_MRP_domain1	410..610	CDD:213217	105/199 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..688		13/36 (36%)
		ABC_membrane	718..991	CDD:279056	101/272 (37%)
		ABCC_MRP_domain2	1039..1258	CDD:213211	139/220 (63%)
		PDZ-binding	1322..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151551
Domainoid	1	1.000	226	1.000	Domainoid score	I2519
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1102	1.000	Inparanoid score	I233
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm40263
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910