DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC9

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_001364202.1	Gene:	ABCC9 / 10060	HGNCID:	60	Length:	1549	Species:	Homo sapiens

Alignment Length:	1357	Identity:	417/1357 - (30%)
Similarity:	686/1357 - (50%)	Gaps:	163/1357 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ILFKGRKKTLEPTDL---------------YNALKEHKAETLGDKFFATWQSEVRSCGDSPKKEP 77
            ::....||   |.||               |..||:            .::.:.:...|.|.:.|
Human   234 LIISAHKK---PIDLKAIGKLPIAMRAVTNYVCLKD------------AYEEQKKKVADHPNRTP 283

  Fly    78 SIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIYGLTLILS- 141
            ||...:.:.||..:.||.....:.:|...|. ||.:..::.......||..   ...|::..||
Human   284 SIWLAMYRAFGRPILLSSTFRYLADLLGFAG-PLCISGIVQRVNETQNGTN---NTTGISETLSS 344

  Fly   142 -------ILFSVLMFHPLMMGLMHL----------AMKMRVAVSTAIYRKALRLSRT--ALGDTT 187
                   .:.:||:|..|::....|          .:.:|.|:...||.|.||||.:  ::|:.|
Human   345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMT 409

  Fly   188 TGQVVNLISNDLGRFDRALIHFHF----LWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQ 248
            .||:.||::.:..:    |:.|.|    ||..|:::::....||..:|.::|.|..:::|..|||
Human   410 LGQINNLVAIETNQ----LMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQ 470

  Fly   249 TFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYI 313
            .|::...:..:..|...:.:|::..|||:.||:::|:|.||..|.:.:|..|..|:||::  .:.
Human   471 YFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLK--TFA 533

  Fly   314 RGTLLSFEITLSRIAIFVSLLGFV----LMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFA 374
            ..|.||..:. :.|.|...|..||    ..|..|....||:..:.::||...:  |..|.:.:||
Human   534 LYTSLSIFMN-AAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPL--FLLSTVVRFA 595

  Fly   375 -EMMVTLRRIKGFMMRSETEALYLKGGQTNKLFEG-------EPLVKLQSFQARWNHDHVE---- 427
             :.:::::::..|::..|......:.|:::..||.       :|....:....|::.|..|
Human   596 VKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTR 660

  Fly   428 -------------------------PVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGE 467
                                     ..|.||:|.:...||..::|.||.|||||:.|||||:...
Human   661 RLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTL 725

  Fly   468 SGKL-----------------KVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCAL 515
            .||:                 :.:..::||:|:|||.||:|.:||.||.|.:|.||:.|...|:|
Human   726 EGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSL 790

  Fly   516 ERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECM 579
            :.|.:|| .||:|.:||||.:||||||.||.:|||:|:..:...||||.||:|.|:..||.:|.:
Human   791 QPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGI 855

  Fly   580 RGFLRD--KLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQEMGD- 641
            ..||:|  :.::||||:||:|.|||.|:.|..|.:...||.::           :.|:..|:.:
Human   856 LKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKD-----------IQTKDVELYEH 909

  Fly   642 ----SNQEQVNAEGDSRNDKSTYSRQS------SRVSRVSVTSVDSSTESILDNERQPAQESRSQ 696
                .|::....|.|...|::|..|::      ||.::..:...|...|...|.:...:...|.:
Human   910 WKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLR 974

  Fly   697 GKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVK----NNDSSSSTDIYI-- 755
            .|:......:|.::| |:.::||:.|..|....:....||:|:.|..    ||...:....|:
Human   975 TKMPWKTCWRYLTSG-GFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAG 1038

  Fly   756 FSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQV 820
            ||.:..|.:...|:.:|....|.:.::..||:.:...:....:.||...|.|.|||||:.|...:
Human  1039 FSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNII 1103

  Fly   821 DEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIAR 885
            |:.:|..:....:..|.....||::....|.:|:..:.:.:||:|::.::...|:||:.|:...:
Human  1104 DQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQ 1168

  Fly   886 SPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYVIS 950
            .|:..|||.|..||:||||...:....:......|.::..|....:.||......|......|::
Human  1169 LPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLT 1233

  Fly   951 VTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFES 1015
            .::.|....  .|.|.:||.:..|:::|..:.|.:|..|:||..|.:|::|..:..:|:|....:
Human  1234 ASIASISGS--SNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGT 1296

  Fly  1016 PDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINAL 1080
            .|..:.|.:|||||.|....|.:||..:.|.  |||.:...|.|.:|:||.||||:|||||..|.
Human  1297 MDPSQVPEHWPQEGEIKIHDLCVRYENNLKP--VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAF 1359

  Fly  1081 FRL-SYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEE 1144
            ||: ...:|.:|||..||..:.||.|||::|||.|:|:||||::|.||||..:..|::||||||.
Human  1360 FRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEI 1424

  Fly  1145 VHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQS 1209
            ..||:.|..||.||::||.|||.|:|||||||.|||||.:|::.||:||||||::|..|:.::|.
Human  1425 AQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQK 1489

  Fly  1210 TIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMV 1266
            .:...|.|.||:|||||::||:.:|.|:|:..|.::|:.:|..||.|. :.||...|
Human  1490 VVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQE-NGVFASFV 1545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	413/1346 (31%)
		ABC_membrane	92..362	CDD:294371	78/297 (26%)
		ABCC_MRP_domain1	412..611	CDD:213217	92/247 (37%)
		ABC_membrane	718..981	CDD:294371	67/268 (25%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	111/221 (50%)
ABCC9	NP_001364202.1	MRP_assoc_pro	222..1546	CDD:188098	417/1357 (31%)
ABCC9	NP_001364202.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..967		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151541
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650