DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC5

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_005679.2	Gene:	ABCC5 / 10057	HGNCID:	56	Length:	1437	Species:	Homo sapiens

Alignment Length:	1389	Identity:	458/1389 - (32%)
Similarity:	697/1389 - (50%)	Gaps:	194/1389 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NPRESAGIFSTLMFCFALPILFKGRKK-TLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDS 72
            :|.::||:||.:.|.:...:.....|| .|...|:::..|...::....:....||.|:...|..
Human    99 HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPD 163

  Fly    73 PKKEPSIIRVILKVFGWQLFLSGIVVGVLELG---------------TRAT-------LPLILGA 115
               ..|:.||:......:|.||.:.:.:.:|.               |:||       |.|:||.
Human   164 ---AASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGL 225

  Fly   116 LIAEFTRNGNGDGLWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSR 180
            |:.|..|:.:....||..|                       ...:::|.|:.|..::|.|:|..
Human   226 LLTEIVRSWSLALTWALNY-----------------------RTGVRLRGAILTMAFKKILKLKN 267

  Fly   181 TALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFL 245
              :.:.:.|:::|:.|||..|...|......|..||:..::...:....:|.....|..:.:||.
Human   268 --IKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFY 330

  Fly   246 PIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKV 310
            |...|.||||:..|.:....||:||:.|||:::.|:.||||.|.|.|.:.::::|..|...:.|.
Human   331 PAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKA 395

  Fly   311 NYIRGTLLSFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAE 375
            .|.:...:.....:..||..|:....:.:|.:|||.:||:|...:|.:...: |..|..:...:|
Human   396 GYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFAL-KVTPFSVKSLSE 459

  Fly   376 MMVTLRRIKGFMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQA--RWNHDH------------- 425
            ..|.:.|.|...:..|...:      .||  ...|.:|::...|  .|:..|
Human   460 ASVAVDRFKSLFLMEEVHMI------KNK--PASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKM 516

  Fly   426 ---------------------------------------------------------VEPVLENI 433
                                                                     ::..|.:|
Human   517 KKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSI 581

  Fly   434 NISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFG 498
            ::.:...:||.:.|.|||||:|||.||||::....|.:.:.|..:|.:|:.|:.||::|||||||
Human   582 DLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFG 646

  Fly   499 LPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDP 562
            ...|:.||.:|:.:|.|..|..:| ..|.|.:|||||:||||||.|||||||:|.....|:||||
Human   647 KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDP 711

  Fly   563 LSAVDTHVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQD 627
            |||:|.|||.|:|...:|..|:.|.|:.||||||:|...|.::.|.:|.|:..||:||::....|
Human   712 LSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGD 776

  Fly   628 ----FGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDNERQ 688
                |..||      :|::...::|::      |.|...|.....:...|......:::...|.|
Human   777 YATIFNNLL------LGETPPVEINSK------KETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQ 829

  Fly   689 PAQ-ESRSQGKIGLGIYGKYFSAGSGWL-MVILVAFFCLGTQILASGGDYFLSYWVK-------- 743
            ..| |.:.||.:...:||.|..|..|.| .::::|.|.|.....|. ..::||||:|
Human   830 LVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAF-STWWLSYWIKQGSGNTTV 893

  Fly   744 --NNDSSSS------------TDIYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVS 794
              .|::|.|            ..||..|  .|.::|...:|.::|....:.:|::||:.:|:.:.
Human   894 TRGNETSVSDSMKDNPHMQYYASIYALS--MAVMLILKAIRGVVFVKGTLRASSRLHDELFRRIL 956

  Fly   795 RTALYFFHANPSGRILNRFAMDLGQVDEILP--AVML--DCIQIFLTISGIIGVLCITNPWYLIN 855
            |:.:.||...|:|||||||:.|:.:||..||  |.|.  :.|.:|..:..|.||.    ||:|:.
Human   957 RSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVF----PWFLVA 1017

  Fly   856 TITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQD 920
            ...:.:.|..|........|:||||:.|.:||..||.::::.||:||.|..........|....|
Human  1018 VGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLD 1082

  Fly   921 IHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGM 985
            .:.:.::.|....|.....|||..:|.:.:..||.........|...||.|:.|:.:||..|:.:
Human  1083 DNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTV 1147

  Fly   986 RQSAELENSMTSVERVLEY---RHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKAD 1047
            |.::|.|...|||||:..|   ..|||....:   :|.|..:|||||.::.|...:||..:  ..
Human  1148 RLASETEARFTSVERINHYIKTLSLEAPARIK---NKAPSPDWPQEGEVTFENAEMRYREN--LP 1207

  Fly  1048 RVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISI 1111
            .|||.::|.|.|:||||||||||:|||||..||||| ..:.|.:.||...|..|||.|||||:||
Human  1208 LVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSI 1272

  Fly  1112 IPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQL 1176
            |||||||||||:|.|||||.||.::::|:|||..|:|:.:::||..|||.|.|.|.|:|||:|||
Human  1273 IPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQL 1337

  Fly  1177 VCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDA 1241
            :|:|||:||..:||::|||||.:|.:||.|||.|||..|.|||:|||||||:|::.|||:|||..
Human  1338 LCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQ 1402

  Fly  1242 GTLVEFGSPFELLTQSWSKVFYGM 1265
            |.:|||.:|..||:...|: ||.|
Human  1403 GQVVEFDTPSVLLSNDSSR-FYAM 1425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	454/1379 (33%)
		ABC_membrane	92..362	CDD:294371	73/291 (25%)
		ABCC_MRP_domain1	412..611	CDD:213217	91/271 (34%)
		ABC_membrane	718..981	CDD:294371	83/288 (29%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	128/221 (58%)
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..41
		CFTR_protein	100..1430	CDD:273530	458/1388 (33%)
		ABC_membrane	<271..447	CDD:294371	51/175 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..538		1/36 (3%)
		ABCC_MRP_domain1	577..759	CDD:213217	87/181 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..827		5/38 (13%)
		ABC_membrane	863..1143	CDD:294371	83/286 (29%)
		ABCC_MRP_domain2	1191..1411	CDD:213211	128/221 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151531
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.660