DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and abcc2

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_004915926.1	Gene:	abcc2 / 100485020	XenbaseID:	XB-GENE-1012796	Length:	1552	Species:	Xenopus tropicalis

Alignment Length:	1377	Identity:	479/1377 - (34%)
Similarity:	738/1377 - (53%)	Gaps:	144/1377 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSC---- 69
            ||..:|...|.:.|.:...|:.||.||.||..||:...:|.|.:.:.:.|....:.:||..
Frog   202 NPELTASFLSRITFNWYNSIVVKGYKKPLEMEDLWELNEEDKTKNMYEIFEKHMKHDVRKAKKDL 266

  Fly    70 ----------------------------------GDSPKKEPSI------------IRVILKVFG 88
                                              .:..|||.||            |:.::|.|.
Frog   267 EKRKNKRKQKESGIEMNGISKAQSQDILVMEEKKKEKKKKEKSIDGTAKDYPKRWLIKTLIKTFP 331

  Fly    89 WQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIYGLTLILSILFSVLMFHPLM 153
            ..|..|.|...:.:| .....|.||..::. ||.:.:........|.:.|:::.|....:.....
Frog   332 STLLTSAIFKLLHDL-LAFVSPQILKVMVT-FTADPSQHQWQGFFYAVLLLVTALLQSFLLQQYF 394

  Fly   154 MGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLE 218
            .|...|.|::|..:..|:|:|||.:|.....::|.|:.|||:|.|..||.......|.||..||:
Frog   395 HGCFVLGMRVRSLLMAAVYKKALTVSNAIRKESTVGETVNLMSADAQRFMDLTNFIHLLWSSPLQ 459

  Fly   219 LLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVI 283
            :.||..||::::|.:.|.|:.:::|.:||...|:.::.:|:.:.....|:|:::||||::||:::
Frog   460 IAISIVFLWEELGPSVLAGLGVMILLIPINAVLATVSRKLQMKNMKNKDKRMKIMNEILNGIKIL 524

  Fly   284 KMYTWEKPFGRLIERLRRSEMSSIRKVNYIRG------TLLSFEITLSRIAIFVSLLGFVLMGGE 342
            |:|.||..|...::.:|..|:..:....|:..      |...|.::::..|::|:    |.....
Frog   525 KLYAWEPSFENQVQEIREKELKDMLHFTYLHSVSLFVFTCAPFLVSVATFAVYVA----VDPSNV 585

  Fly   343 LTAERAFSVTAFYNILRRTVCKFFPSGM-----SQFAEMMVTLRRIKGFMMRSETEALYLKGGQT 402
            |.||:||:..:.:||||      ||..|     |...:..|:..|::.::           ||..
Frog   586 LNAEKAFTSISLFNILR------FPLAMLPMLISSMVQTSVSSARLEKYL-----------GGDN 633

  Fly   403 --NKLFEGEP----LVKLQSFQARWNHDHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAIL 461
              ......:|    .|:.......|..| ..|.:.|:|:.:....||||:|.||||||||:.|:|
Frog   634 LDTSAIRCDPNIDAAVQFSDATFSWEED-ANPAVNNVNLDIKEGNLVAVVGGVGSGKSSLVSAML 697

  Fly   462 GELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELLHG-D 525
            ||:....|.:.::|.|:|..|:.|:.||::::|||||..||:.||:.|:..|||..|.|:|.| |
Frog   698 GEMDHVGGYINIKGSIAYVPQQAWIQNATLKNNILFGSKMDEERYQKVLEACALLPDLEMLPGHD 762

  Fly   526 RTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECM--RGFLRDKLV 588
            .:.:||:|.:|||||:.|:|||||||..||.|:|||||||||.|||:|:||:.:  .|.|::|..
Frog   763 ESEIGEKGINLSGGQKQRVSLARAVYNDADIYILDDPLSAVDAHVGKHIFEKVVGPNGLLKNKTR 827

  Fly   589 ILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQEMGDSNQEQV------ 647
            |||||.:.||:|||.||::...:::..|:|:.:..:...|.:.|...|::...::.|..
Frog   828 ILVTHGVSFLKHADDIVVLVNSRVTETGSYKTLQANNGAFAEFLRLYAKQNDQTDNEATVFTGED 892

  Fly   648 -NAEGDS---------------RNDKSTYSRQSSRVS-----RVSVTSVDSSTESILDNERQP-- 689
             ..:||.               :.:.|...|:.|.||     |.||..|......|..|:.:.
Frog   893 DEDDGDQVETAEVIEDIVASTVKRENSMRQRKRSSVSMNGTLRRSVKDVTKKKTGIGSNDTKGQK 957

  Fly   690 --AQESRSQGKIGLGIYGKYFSA-GSGWLMVILVAFFCLGTQILASGGDYFLSYWVKNNDS---- 747
              .:|:...||:...:|.||..| |.|:...|.|::.......:  |.:.:||.|..:.:.
Frog   958 LIEKETVETGKVKFKLYLKYLRAVGWGFSFWIFVSYILQNAAFV--GQNIWLSDWTGDAEKYYNI 1020

  Fly   748 ---SSSTD--IYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSG 807
               :|..|  :.:|..:..|..:|.||...|....|:.:|..||..:...:.|..:.||...|:|
Frog  1021 TYPASQRDMRVGVFGALGVAQALFVLLGAFLVSGGAVRASRMLHTQLLHNILRVPMRFFDTTPTG 1085

  Fly   808 RILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLS 872
            ||:||||.|:..|||.:|......|..||.:.|.:.::|:..|.:....:.:.:.::|::.||::
Frog  1086 RIVNRFAKDILTVDETIPMSFRSWIACFLGVIGTLFIICLATPIFAAVIVPLAIFYYFVQRFYVT 1150

  Fly   873 TSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFG 937
            |||.|:||:::.|||:||||..|::|||.|||...||...:..::..|.:....|:::.:||...
Frog  1151 TSRQLRRLDSVTRSPIYSHFGETVSGLSVIRAYGHQDRFLQHNEDTIDNNQKSVYSWIVSNRWLA 1215

  Fly   938 YYLDLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVL 1002
            ..|:......|....|.:.......:.|.:||.|:.|:::|.|:.|.:|.::|||.::.:||||.
Frog  1216 IRLEFVGNLTVFFAALFAVLGRGTVDSGTVGLSISSALNITQTLNWLVRMTSELETNIVAVERVD 1280

  Fly  1003 EYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVG 1067
            ||..:|.|.::  .:|.:||.:||::|::......:||.|:  .|.||:.::..|...||:||||
Frog  1281 EYIKVEREAQW--VEDHRPPKDWPEKGVVQFVDYKVRYRPE--LDLVLQGISCTINSMEKVGIVG 1341

  Fly  1068 RTGAGKSSLINALFRLSYNE-GSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFE 1131
            |||||||||.|.:||:..:. |.::||..||..|||||||.|::||||:||||||.||.|||||.
Frog  1342 RTGAGKSSLTNCIFRIIESAGGKIMIDGLDIASIGLHDLRQKLTIIPQDPVLFSGNLRMNLDPFN 1406

  Fly  1132 QYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEAT 1196
            ||.||.:|:|||..|||..|..|...|...|:|||.|.|||||||||||||:||:::||::||||
Frog  1407 QYTDEDIWKALELSHLKPFVEGLQEKLFHEVSEGGENLSVGQRQLVCLARALLRKSKILILDEAT 1471

  Fly  1197 ANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKV 1261
            |.||.:||.|||.|||.:|.|||||||||||:||:||.|:||||||.::|||||.|||.:...
Frog  1472 AAVDLETDNLIQRTIRSEFADCTVLTIAHRLHTIMDSSRLMVLDAGKIIEFGSPDELLQRQGH-- 1534

  Fly  1262 FYGMVLQTGRSS 1273
            |:.|....|..|
Frog  1535 FFSMAKDAGIDS 1546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	475/1359 (35%)
		ABC_membrane	92..362	CDD:294371	77/275 (28%)
		ABCC_MRP_domain1	412..611	CDD:213217	98/201 (49%)
		ABC_membrane	718..981	CDD:294371	78/271 (29%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	133/221 (60%)
abcc2	XP_004915926.1	MRP_assoc_pro	10..1544	CDD:188098	477/1373 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930