Protein Alignment Nthl1 and NTHL1

DIOPT Version :10

• Sequence 1: NP_610078.2
• Gene: Nthl1 / 35365
• FlyBaseID: FBgn0032907
• Length: 388
• Species: Drosophila melanogaster
• Sequence 2: NP_002519.2
• Gene: NTHL1 / 4913
• HGNCID: 8028
• Length: 304
• Species: Homo sapiens
• Alignment Length: 277
• Identity: 135/277 - (48%)
• Similarity: 166/277 - (59%)
• Gaps: 31/277 - (11%)

  Fly   131 REEVEPQIKQE-APEDSPSFSEVQAP---------------------HPL---------WFNHLE 164
            |||..|..::| |.|...|.|.|:.|                     .||         |...|.
Human    25 REEPGPLRRREAAAEARKSHSPVKRPRKAQRLRVAYEGSDSEKGEGAEPLKVPVWEPQDWQQQLV 89

  Fly   165 NIRIMRNSRTAPVDTMGCHRCADLKADSKTQRFQNLVALMLSSQTKDQTTYEAMNRLKDRGLTPL 229
            |||.|||.:.||||.:|...|.|..|..|.:|:|.|::||||||||||.|..||.||:.||||..
Human    90 NIRAMRNKKDAPVDHLGTEHCYDSSAPPKVRRYQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVD 154

  Fly   230 KVKEMPVTELENLLHPVSFYKNKAKYLKQTVEILTDKYGSDIPDNVKDLVALPGVGPKMAHICMA 294
            .:.:.....|..|::||.|:::|.||:|||..||...||.|||.:|.:|||||||||||||:.||
Human   155 SILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVAELVALPGVGPKMAHLAMA 219

  Fly   295 VAWNKITGIGVDVHVHRLSNRLGWVPKPTKEPEQTRVALEKWLPFSLWSEVNHLFVGFGQTICTP 359
            |||..::||.||.||||::|||.|..|.||.||:||.|||:|||..||.|:|.|.|||||..|.|
Human   220 VAWGTVSGIAVDTHVHRIANRLRWTKKATKSPEETRAALEEWLPRELWHEINGLLVGFGQQTCLP 284

  Fly   360 VKPNCGECLNKDICPSA 376
            |.|.|..|||:.:||:|
Human   285 VHPRCHACLNQALCPAA 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nthl1	NP_610078.2	Nth	197..376	CDD:439947	103/178 (58%)
NTHL1	NP_002519.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..72		11/46 (24%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	28..52		8/23 (35%)
		Nth	122..302	CDD:439947	104/180 (58%)