DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9272 and Nthl1

DIOPT Version :9

Sequence 1:	NP_610078.2	Gene:	CG9272 / 35365	FlyBaseID:	FBgn0032907	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001099198.1	Gene:	Nthl1 / 29541	RGDID:	1309289	Length:	300	Species:	Rattus norvegicus

Alignment Length:	295	Identity:	137/295 - (46%)
Similarity:	176/295 - (59%)	Gaps:	22/295 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 EPLSPARVAPKKFRKDDRMVTRVQMGSATVVICKVVPDAVDSPVRVDKIREEVEPQIKQEAPEDS 146
            |.|:|...|.:. ||..:.|.|                    |.:..|:....|....:|..:..
  Rat    25 EELAPRETAAEG-RKSHKPVRR--------------------PRKKQKVHVAYEVANGEEGEDAE 68

  Fly   147 PSFSEVQAPHPLWFNHLENIRIMRNSRTAPVDTMGCHRCADLKADSKTQRFQNLVALMLSSQTKD 211
            |....|..|.. |...|.||||||:.:.||||.:|..:|.|:.|..|.:|:|.|::|||||||||
  Rat    69 PLKVPVWEPQN-WQQQLANIRIMRSKKDAPVDQLGAEQCYDITAPPKVRRYQVLLSLMLSSQTKD 132

  Fly   212 QTTYEAMNRLKDRGLTPLKVKEMPVTELENLLHPVSFYKNKAKYLKQTVEILTDKYGSDIPDNVK 276
            |.|..||.||:.||||...:.:.....|..|::||.|:::|.|::|||..||..:|..|||.:|.
  Rat   133 QVTAGAMQRLRARGLTVESILQTDDDLLGRLIYPVGFWRSKVKFIKQTTAILQQRYEGDIPASVA 197

  Fly   277 DLVALPGVGPKMAHICMAVAWNKITGIGVDVHVHRLSNRLGWVPKPTKEPEQTRVALEKWLPFSL 341
            :|||||||||||||:.|||||..::||.||.||||::|||.|..|.||.||:||..||:|||..|
  Rat   198 ELVALPGVGPKMAHLAMAVAWGTVSGIAVDTHVHRIANRLKWTKKMTKSPEETRRNLEEWLPRVL 262

  Fly   342 WSEVNHLFVGFGQTICTPVKPNCGECLNKDICPSA 376
            |||:|.|.|||||.||.||.|.|..||||.:||:|
  Rat   263 WSEINGLLVGFGQQICLPVHPRCQACLNKALCPAA 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9272	NP_610078.2	Nth	169..376	CDD:223255	115/206 (56%)
		ENDO3c	205..355	CDD:214684	86/149 (58%)
		FES	356..376	CDD:197771	12/19 (63%)
Nthl1	NP_001099198.1	PRK10702	79..294	CDD:182661	119/215 (55%)
		ENDO3c	126..275	CDD:214684	85/148 (57%)
		FES	277..297	CDD:197771	12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346740
Domainoid	1	1.000	162	1.000	Domainoid score	I3907
eggNOG	1	0.900	-	-		E1_COG0177
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1897
Inparanoid	1	1.050	258	1.000	Inparanoid score	I3067
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1322642at2759
OrthoFinder	1	1.000	-	-		FOG0003205
OrthoInspector	1	1.000	-	-		oto96747
orthoMCL	1	0.900	-	-		OOG6_100563
Panther	1	1.100	-	-	LDO	PTHR43286
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2154
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760