DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RPA2 and RFA2

DIOPT Version :9

Sequence 1:	NP_001260652.1	Gene:	RPA2 / 35364	FlyBaseID:	FBgn0032906	Length:	246	Species:	Drosophila melanogaster
Sequence 2:	NP_014087.1	Gene:	RFA2 / 855404	SGDID:	S000005256	Length:	273	Species:	Saccharomyces cerevisiae

Alignment Length:	264	Identity:	65/264 - (24%)
Similarity:	104/264 - (39%)	Gaps:	36/264 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GDFNATQTAPTGAAS--NQKGEGIVPLVVKQIV----DAPEGNIELFGMQYAMACVVAIVRNVET 64
            |.|..:::.|....|  |.:...:.|:.:|||:    |..:|.......:....|.|.:|||:..
Yeast    16 GGFENSESRPGSGESETNTRVNTLTPVTIKQILESKQDIQDGPFVSHNQELHHVCFVGVVRNITD 80

  Fly    65 SSTKITYTLEDHSGRIDAHYWLEEGDALK---------------APEVMVNNYVKVYGTTRSQGG 114
            .:..|..|:||.:|:|:...|.|:.:.|.               |.:..:..||||:|..:..||
Yeast    81 HTANIFLTIEDGTGQIEVRKWSEDANDLAAGNDDSSGKGYGSQVAQQFEIGGYVKVFGALKEFGG 145

  Fly   115 SKTLMIFKLLPVLDPNEVCTHLLEVLNARYRAEDYQSKGGAGAGAGASSGSGSIADFTASQSSAI 179
            .|.:....:.|:...|||.||.|||:.....|.....:    ....||:.:|.  .......:..
Yeast   146 KKNIQYAVIKPIDSFNEVLTHHLEVIKCHSIASGMMKQ----PLESASNNNGQ--SLFVKDDNDT 204

  Fly   180 VSGLEPKQQAVFQAIKSNVSEEGISRKELKAKFSHISDS----ELT--NILDFMISEGHIYSSID 238
            .||..|.|: :.:..|...  ||............||.|    |.|  |....:..:|.||.:.|
Yeast   205 SSGSSPLQR-ILEFCKKQC--EGKDANSFAVPIPLISQSLNLDETTVRNCCTTLTDQGFIYPTFD 266

  Fly   239 ADHF 242
            .::|
Yeast   267 DNNF 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPA2	NP_001260652.1	RFA2	12..246	CDD:227560	63/258 (24%)
		RPA2_DBD_D	52..144	CDD:239924	32/106 (30%)
		RPA_C	<182..238	CDD:285937	15/61 (25%)
RFA2	NP_014087.1	RFA2	1..273	CDD:227560	65/264 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344788
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5235
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37712
Inparanoid	1	1.050	68	1.000	Inparanoid score	I1707
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58029
OrthoFinder	1	1.000	-	-		FOG0003638
OrthoInspector	1	1.000	-	-		oto100378
orthoMCL	1	0.900	-	-		OOG6_102423
Panther	1	1.100	-	-	LDO	PTHR13989
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1086
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790