DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RPA2 and STN1

DIOPT Version :9

Sequence 1:	NP_001260652.1	Gene:	RPA2 / 35364	FlyBaseID:	FBgn0032906	Length:	246	Species:	Drosophila melanogaster
Sequence 2:	NP_079204.2	Gene:	STN1 / 79991	HGNCID:	26200	Length:	368	Species:	Homo sapiens

Alignment Length:	262	Identity:	45/262 - (17%)
Similarity:	88/262 - (33%)	Gaps:	58/262 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LVVKQIVDAPEG----NIELF-GMQYAMACVVAIVRNVETSSTKITYTLEDHSGRIDAHYW--LE 87
            |.::.|:|..|.    .:.|: |.......|:..|..|.......:|.::|.:|.|:...|  |.
Human    29 LYIRDILDMKESRQVPGVFLYNGHPIKQVDVLGTVIGVRERDAFYSYGVDDSTGVINCICWKKLN 93

  Fly    88 EGDALKAP-----------------------EVMVNNYVKVYGTTRSQGGSKTLMIFKLLPVLDP 129
            ......||                       ::.:.:.::|.|:.|:....:.:.......|.||
Human    94 TESVSAAPSAARELSLTSQLKKLQETIEQKTKIEIGDTIRVRGSIRTYREEREIHATTYYKVDDP 158

  Fly   130 --NEVCTHLLEVLNARYRAEDYQSKGGAGAGAGASSGSG-----SIADFTASQSSAIVSGLEPKQ 187
              |.....:||:.....:..|......|.....|.|..|     |:....:.::...:  :|.:.
Human   159 VWNIQIARMLELPTIYRKVYDQPFHSSALEKEEALSNPGALDLPSLTSLLSEKAKEFL--MENRV 221

  Fly   188 QAVFQ----------------AIKSNVSEEGISRKELKAKFSHISDSELTNILDFMISEGHIYSS 236
            |:.:|                .|.|..|::...:|:..:|..|   |...|.:..:..:|.::..
Human   222 QSFYQQELEMVESLLSLANQPVIHSASSDQVNFKKDTTSKAIH---SIFKNAIQLLQEKGLVFQK 283

  Fly   237 ID 238
            .|
Human   284 DD 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPA2	NP_001260652.1	RFA2	12..246	CDD:227560	45/262 (17%)
		RPA2_DBD_D	52..144	CDD:239924	20/118 (17%)
		RPA_C	<182..238	CDD:285937	12/71 (17%)
STN1	NP_079204.2	Interaction with CTC1. /evidence=ECO:0000269\|PubMed:23851344	1..185		27/155 (17%)
		hOBFC1_like	58..155	CDD:239929	14/96 (15%)
		STN1_2	157..334	CDD:286279	24/134 (18%)
		Winged helix-turn-helix (wHTH) 1	191..295		17/100 (17%)
		Winged helix-turn-helix (wHTH) 2	296..368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5235
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900