DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RPA2 and rpa2

DIOPT Version :9

Sequence 1:	NP_001260652.1	Gene:	RPA2 / 35364	FlyBaseID:	FBgn0032906	Length:	246	Species:	Drosophila melanogaster
Sequence 2:	NP_571786.2	Gene:	rpa2 / 65226	ZFINID:	ZDB-GENE-010131-3	Length:	271	Species:	Danio rerio

Alignment Length:	257	Identity:	81/257 - (31%)
Similarity:	129/257 - (50%)	Gaps:	27/257 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FGDFNATQTAPTGAASNQKG----EGIVPLVVKQIVDAPE-------GNIELFGMQYAMACVVAI 58
            ||...|:|      ..::||    :.|||..|.|::.|.:       |.:|:     |...:|.:
Zfish    22 FGSPAASQ------GGDKKGRTRAQQIVPCTVSQLLSAVQAEDVFKVGEVEI-----AQVTIVGV 75

  Fly    59 VRNVETSSTKITYTLEDHSGR-IDAHYWLEEGD-ALKAPEVMVNNYVKVYGTTRSQGGSKTLMIF 121
            :|:.:.|:..|.|.::|.:.. :|...|::..| .:....:...:||||.|..||...:::|:.|
Zfish    76 IRSTDKSTINIQYKVDDMTAAPMDVKQWIDTEDMGVDNSVIPPGSYVKVSGNLRSFQNNRSLVAF 140

  Fly   122 KLLPVLDPNEVCTHLLEVLNARYRAEDYQSKGGAGAGAGASSGSGSIADFTASQSSA---IVSGL 183
            .:..:.|.|||.:|:|||:||..:....|:.||.|.....|..|.:....|...|.|   :|:||
Zfish   141 SVRVLEDMNEVTSHMLEVVNAHLQQSKPQNMGGGGGMMPVSHTSMNSMGTTGGYSGANMMLVNGL 205

  Fly   184 EPKQQAVFQAIKSNVSEEGISRKELKAKFSHISDSELTNILDFMISEGHIYSSIDADHFICT 245
            ...|..|...|||....:|||..|||.|.:.:|.:.:...:||:.:||||:|:||.|||..|
Zfish   206 SANQNQVLSLIKSCQEPQGISMHELKQKLNSMSANVIRQTVDFLSNEGHIFSTIDEDHFRST 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RPA2	NP_001260652.1	RFA2	12..246	CDD:227560	78/250 (31%)
		RPA2_DBD_D	52..144	CDD:239924	28/93 (30%)
		RPA_C	<182..238	CDD:285937	22/55 (40%)
rpa2	NP_571786.2	RFA2	20..267	CDD:227560	80/255 (31%)
		RPA2_DBD_D	69..163	CDD:239924	28/93 (30%)
		RPA_C	162..262	CDD:285937	34/99 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10597
eggNOG	1	0.900	-	-		E1_COG5235
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37712
Inparanoid	1	1.050	116	1.000	Inparanoid score	I4802
OMA	1	1.010	-	-		QHG58029
OrthoDB	1	1.010	-	-		D561832at33208
OrthoFinder	1	1.000	-	-		FOG0003638
OrthoInspector	1	1.000	-	-		oto41766
orthoMCL	1	0.900	-	-		OOG6_102423
Panther	1	1.100	-	-	LDO	PTHR13989
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1086
SonicParanoid	1	1.000	-	-		X4625
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870