DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mtp and mttp

DIOPT Version :9

Sequence 1:	NP_610075.2	Gene:	Mtp / 35362	FlyBaseID:	FBgn0266369	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_998135.2	Gene:	mttp / 406207	ZFINID:	ZDB-GENE-040419-2	Length:	884	Species:	Danio rerio

Alignment Length:	905	Identity:	221/905 - (24%)
Similarity:	403/905 - (44%)	Gaps:	114/905 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KLQNQVILQELGRD----SSSAETSYTFETDLKINSVWSGDE---DQLLEVFISGSKVDASGK-- 94
            ||.......|:|.:    |......:...:|:.||..|...|   :|||:|.||..:|:::||
Zfish    30 KLYRYSYSTEVGLNRPTGSPGGNVGFRISSDVDINLAWRNPEIQDEQLLQVKISNIQVESAGKHS 94

  Fly    95 ----------ARSI---TRIP--DRPFYISLVRGQPDKVIAHTSKDQSLLNLERGIASLLQLRLD 144
                      |.||   .|:.  .|||.:....|:...:.|..::..::.||:||:||:|.::|.
Zfish    95 RKNNIFHGSSAESILGKVRLEALQRPFLVLWKMGKIRSLYAQKAEPATVKNLKRGVASMLMMQLK 159

  Fly   145 ASQEEELDVSGLCRVSYNVKSSTKVEKTK--RDCSLWDLR-VNYNPEEALGVTQQ-AQETVFYEL 205
            :.:..|.|.||.|.|.|.| :..:|.:||  ..|...:.. ..::|  .||::.: |.|||.  .
Zfish   160 SGKMSEADASGKCLVEYKV-NKHQVIRTKHLETCKSQETGFTTHSP--VLGISGKCAAETVI--T 219

  Fly   206 SSEGTLLHAESQENHRLNLAAKPDVGSFV--KSSLILQHVSQGSEEVKQLQLGSLDKAIQSLLEW 268
            ...|.:..|:::|.|.|::.|:....:.|  :.||.|:.:..|..||....:..:.||:
Zfish   220 LENGIIKSADAKETHVLSINARHKAATKVLSRQSLTLKAIEAGPAEVAGKDVAGVVKAL------ 278

  Fly   269 YRVFELESDVDGMISAIKEQT---------LEDQLKASLTELQSADVGKSSLALAYVKLIPLARI 324
                   .|....:..|.|:|         |.:..||..::|:...:.|:....:::.|:...|.
Zfish   279 -------DDKFLSVGVIVEKTKPKCKGCPNLMETWKAVRSQLEPNSLSKAEAPRSFLTLVHSLRK 336

  Fly   325 TRQEQFEDLLTEHAE-VLPQLVDLLGAVQTFDAHNATFGFLYKESETTSEQLDLLEKYLQSLAVA 388
            :.:.:...:|...:: .||||||.:.:.||..:.:|...||   ..:..:.|.|.|::|.:...|
Zfish   337 SSKSEILTVLQNCSKTALPQLVDAVTSAQTPSSLSAILEFL---DFSKKDGLILQERFLYACGFA 398

  Fly   389 THPDRKIVEHLFGLLEQESIK-KHLKLRESVIQTVATLTRQSGLD--VEDPLLKEVRSYLLQGLT 450
            :||...:::   .|||....| ...:::|||:..:..|.|:..|.  .:.|.:.:|:..||.|..
Zfish   399 SHPTESMLQ---SLLEVSQGKIGSTEIKESVVIIMGALLRKLCLKGACDLPAVLKVKELLLAGPD 460

  Fly   451 S----KEPTLYIRALQNLQDPATIEALLEHAQTGEAPNLSVAALQALKAFPLGSFNSSHRLQFES 511
            |    .|..:|:.||:|...|..|..|.::|:: |....|..|:.||:.:......:..:.....
Zfish   461 STQEESEVQMYLLALKNALLPEGIPVLAKYAES-EVGAYSTIAITALQRYDPALITAEVKKALNR 524

  Fly   512 IFYQRKRRFDSSARTLALDIILSLRPTQEQLGNFLDYLASNDRQFEIKTYVLQKLR-MLAEKCPR 575
            |::|.:|.::.:.|..|.|:|:|..|:..::.|.|  |:......|:..|:|.|:: :|..:.|.
Zfish   525 IYHQNQRIYEKNVRAAAADVIMSSNPSYMEVKNLL--LSIGHLPHEMNKYMLSKIQDVLRFQMPA 587

  Fly   576 FRALFKSELVKRRHVNNYNVLGQKGLTTVLTRQLSQAP----AFNETLLSTQEVYQGILKRGSVE 636
            ::.:  .:::|....:||:...:.|.::..:..:::..    .:|..:|.:.   .|:|:|.::.
Zfish   588 YKLV--RQVMKDMISHNYDRFSKTGSSSAYSGFMAETVDVTCTYNLDILYSG---SGVLRRSNMN 647

  Fly   637 FLLHAGRSQASSFKLGIYTAGLGSLVGDGDSGDGNDAIPADDEFSEDEAVTAGMEISVQGAQLRP 701
            ....:..:.....::.|...||.||:.         |.|  ||..|:....|||...:...||||
Zfish   648 IYGQSNNALLHGLQVTIEAQGLESLIA---------ATP--DEGEEELESFAGMSALLFDVQLRP 701

  Fly   702 LVFFSGQTELMGHVWGGSASDSTPAYQATTLSQDNEHYIILTSGATLHWRVLGARSVDLNGKVGF 766
            :.||.|.::||..::..| .|.....:...|..|:...|.|.||...........|:|::|.:.|
Zfish   702 VTFFKGYSDLMSKMFSMS-GDPINVVKGLILLTDHSQVIPLQSGLRASAEFQAGLSIDISGGMEF 765

  Fly   767 SLWNRNAQTEIQQNTGSAVLGHLAVGFTYAKLVQDF-SITHEPKLSLNADLDFYSGIK------- 823
            |||.|.::|.:.......::|::.|.       .|| |...|......|.|||.:.::
Zfish   766 SLWYRESKTSVNNRGALVIIGNMTVD-------TDFVSAGVEVGFETEATLDFITTVQFSEYPFL 823

  Fly   824 LCMQLQRPEQLLKQTNVRSVFLQSVDRPYAKHVRSTLSHKTAGCTFALNQKNNEMCNLIF 883
            :|||:.:.....::|..:...|.:......|..|..:   ..|..|.|:|:|:.||..:|
Zfish   824 VCMQMDKTTFPFRETVSKQEKLPTGQMFSRKRSRDQV---VPGSEFPLHQENSNMCKKVF 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtp	NP_610075.2	LPD_N	38..567	CDD:214755	146/574 (25%)
mttp	NP_998135.2	Vitellogenin_N	26..578	CDD:331790	146/574 (25%)
mttp	NP_998135.2	DUF1943	<703..811	CDD:312626	30/115 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581691
Domainoid	1	1.000	110	1.000	Domainoid score	I6270
eggNOG	1	0.900	-	-		E1_KOG4337
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H212
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3845
OMA	1	1.010	-	-		QHG45382
OrthoDB	1	1.010	-	-		D299169at33208
OrthoFinder	1	1.000	-	-		FOG0006503
OrthoInspector	1	1.000	-	-		oto40274
orthoMCL	1	0.900	-	-		OOG6_108584
Panther	1	1.100	-	-	O	PTHR13024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6239
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770