DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtp and Mttp

DIOPT Version :9

Sequence 1:	NP_610075.2	Gene:	Mtp / 35362	FlyBaseID:	FBgn0266369	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001101197.1	Gene:	Mttp / 310900	RGDID:	1308388	Length:	896	Species:	Rattus norvegicus

Alignment Length:	930	Identity:	241/930 - (25%)
Similarity:	419/930 - (45%)	Gaps:	107/930 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLLLALFLGLLED------GKTALIAPNSQQIFKL--QNQVILQELGRDSSSAETSYTFETDLKI 68
            :||..|||.....      |.|..::.|:::::||  ..:|.| :.|:........|...:|:.:
  Rat     2 ILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFL-DGGKGKLQDSVGYRISSDVDV 65

  Fly    69 NSVW---SGDEDQLLEVFISGSKVDASG---------KARSITRIPD--------RPFYISLVRG 113
            ..:|   .||:|||::|.|:...|:.:|         |.:|..:|..        ||..:.||||
  Rat    66 VLLWRNPDGDDDQLIQVTITAVNVENAGQQRGEKSIFKGKSTPKIVGKDNLEALRRPMLLHLVRG 130

  Fly   114 QPDKVIAHTSKDQSLLNLERGIASLLQLRLDASQEEELDVSGLCRVSYNVKSSTKVEKTKR--DC 176
            :..:..::.::...:.||:||:|||.|::|.:....|:|:||.|:|:|..:.. ||.|.|.  .|
  Rat   131 KVKEFYSYENEPVGIENLKRGLASLFQMQLTSGTTNEVDISGDCKVTYQAQQD-KVVKIKALDTC 194

  Fly   177 SLWDLRVNY-NPEEALGVTQQAQETVFYEL-SSEGTLLHAESQENHRLNLAAKPDVGSFV-KSSL 238
            .:  .|..: ...:.||||.:|.....|:: .|..|.:.||......||. .:...|..| |..|
  Rat   195 KI--ERSGFTTANQVLGVTSKATSVTTYKIEDSFVTAVVAEETRAFALNF-LQTVAGKIVSKQKL 256

  Fly   239 ILQHVSQGSEEVKQLQLGSLDKAIQSLLEWYRVFELESDVDGMISAIKE-QTLEDQLKASLTELQ 302
            .|:....|...|...|:..:.|||.|.   |:...:...|  :.|..|. .:|.:..::....|:
  Rat   257 ELKTTEAGPRMVPGKQVAGVIKAIDSK---YKAIPIVGQV--LQSVCKGCPSLAEHWQSIRKHLE 316

  Fly   303 SADVGKSSLALAYVKLIPLARITRQEQFEDLL-TEHAEVLPQLVDLLGAVQTFDAHNATFGFLYK 366
            ..::..:....:::..|...|.:|:|:...:| .|..||||||||.:.:.||..:..|...||..
  Rat   317 PENLSNAEAVQSFLAFIQHLRTSRREEILQILKAEKKEVLPQLVDAVTSAQTPASLEAILDFLDF 381

  Fly   367 ESETTSEQLDLLEKYLQSLAVATHPDRKIVEHLFGLLEQESIKKHLKLRESVIQTVATLTRQ--- 428
            :|:::   :.|.|::|.:...|:|||.::::.|....:......  .:||||:..:..|.|:
  Rat   382 KSDSS---IILQERFLYACGFASHPDEELLQALLSKFKGSFASN--DIRESVMIIIGALVRKLCQ 441

  Fly   429 -SGLDVEDPLLKEVRSYLLQGLTSKE----PTLYIRALQNLQDPATIEALLEHAQTGEAPNLSVA 488
             .|..::  .:.|.:..:|.||...|    .|:|:.||:|...|..|..||::|:.||.| :|..
  Rat   442 NEGCKLK--AVVEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGP-VSHL 503

  Fly   489 ALQALKAFPLGSFNSSHRLQFESIFYQRKRRFDSSARTLALDIILSLRPTQEQLGNFLDYLASND 553
            |...|:.:.........:.....|::|.::..:.:.||.|..:||...|:...:.|.|  |:..:
  Rat   504 ATTVLQRYDASFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVILKNNPSYMDVKNIL--LSIGE 566

  Fly   554 RQFEIKTYVLQ------KLRMLAEKCPRFRALFKSELVKRRHVNNYNVLGQKGLTTVLTRQLSQA 612
            ...|:..|:|.      ...|.|.|..|       .::|...|:||:...:.|.::..|..:.::
  Rat   567 LPKEMNKYMLTIVQDILHFEMPASKMIR-------RVLKEMIVHNYDRFSKSGSSSAYTGYVERS 624

  Fly   613 PAFNETLLSTQEVY--QGILKRGSVEFLLHAGRSQASSFKLGIYTAGLGSLVGDGDSGDGNDAIP 675
            |....| .|...:|  .|||:|.::....:.|:::....::.|...||..|:.         |.|
  Rat   625 PHAAST-YSLDILYSGSGILRRSNLNIFQYIGKAELHGSQVVIEAQGLEGLIA---------ATP 679

  Fly   676 ADDEFSEDEAVTAGMEISVQGAQLRPLVFFSGQTELMGHVWGGSASDSTPAYQATTLSQDNEHYI 740
              ||..|:....|||...:...||||:.||:|.::||..:...| .|.....:...|..|:...|
  Rat   680 --DEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSAS-GDPVSVVKGLILLIDHSQDI 741

  Fly   741 ILTSGATLHWRVLGARSVDLNGKVGFSLWNRNAQTEIQQNTGSAVLGHLAVGFTYAKLVQDFSIT 805
            .|.||...:..:.|..::|::|.:.||||.|.::|.::......:...:.|..::.|      ..
  Rat   742 QLQSGLKANMDIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDITVDSSFVK------AG 800

  Fly   806 HEPKLSLNADLDFYSGIK-------LCMQLQRPEQLLKQTNVRSVFLQSVDRPYAKHVRSTLSHK 863
            .|.:....|.|:|.|.::       :|||:.:.|..|:|...:...| |..|.|....|.  ...
  Rat   801 LESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERL-STGRGYVSRRRK--ESL 862

  Fly   864 TAGCTFALNQKNNEMCNLIF 883
            ..||...|:|:|:||||::|
  Rat   863 VPGCELPLHQENSEMCNVVF 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtp	NP_610075.2	LPD_N	38..567	CDD:214755	148/571 (26%)
Mttp	NP_001101197.1	Vitellogenin_N	28..580	CDD:421421	149/571 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341680
Domainoid	1	1.000	129	1.000	Domainoid score	I5167
eggNOG	1	0.900	-	-		E1_KOG4337
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H212
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3272
OMA	1	1.010	-	-		QHG45382
OrthoDB	1	1.010	-	-		D299169at33208
OrthoFinder	1	1.000	-	-		FOG0006503
OrthoInspector	1	1.000	-	-		oto95486
orthoMCL	1	0.900	-	-		OOG6_108584
Panther	1	1.100	-	-	O	PTHR13024
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6239
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770