DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtp and mttp.2

DIOPT Version :9

Sequence 1:	NP_610075.2	Gene:	Mtp / 35362	FlyBaseID:	FBgn0266369	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_002939768.2	Gene:	mttp.2 / 100127803	XenbaseID:	XB-GENE-5744488	Length:	881	Species:	Xenopus tropicalis

Alignment Length:	882	Identity:	232/882 - (26%)
Similarity:	398/882 - (45%)	Gaps:	131/882 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ETDLKINS------VW---SGDEDQLLEVFISGSKVDASGKARSITR-IPD-----RPFYISLVR 112
            ||:|||::      :|   |..|:||:.|.|..|.|..:..:.|:.: :.|     ||.....:.
Frog    58 ETNLKIDANVQTYLLWRNKSQLEEQLVHVQIKDSTVHRNNNSNSVIKHVIDTGNLGRPVLFHWIS 122

  Fly   113 GQPDKVIA--HTSKDQS-LLNLERGIASLLQLRLDASQEEELDVSGLCRVSYNVKSSTKVEKTKR 174
            |   |::.  .|.:|:| :|:|:||:.||.|.:..:..:.|.||||.|.|:|.: |...::|||.
Frog   123 G---KIVGLYGTKEDKSRILDLKRGLVSLFQFQTFSGIQTEEDVSGTCSVTYQI-SDGSIKKTKD 183

  Fly   175 DCSLWDLRVNYNPEEALGVTQQAQETVF---------YELSS-EGTLLHAESQENHRLNLAAKPD 229
            ..|...|...|          ||..|||         .|||. .||:..|.|:|:|.:.|.|...
Frog   184 LSSCTALPFGY----------QADNTVFGVSLNSTSKSELSHVGGTIQTAASEESHIVYLRATSL 238

  Fly   230 VGSFVKSSLILQHVSQ--GSEEVKQLQLGSLDKAIQSLLEWYRVFELESDV----DGMISAIKEQ 288
            :||.|.|...|:..|.  |..|:.:   .|:...::.|.|.|:..|:.|..    :|      ..
Frog   239 LGSEVASRQYLELKSSIPGPAEIPE---DSVQNILKLLPEKYQKIEIASHPQRRNEG------SH 294

  Fly   289 TLEDQLKASLTELQSADVGKSSLALAYVKLIPLARITRQEQFEDLLTEHA-EVLPQLVDLLGAVQ 352
            .|::.||.|..:|....:.|.|....:..::.:.|..::.....||.:.| |::|..:|.....|
Frog   295 LLKNYLKTSPKKLTKLTISKVSTTRQFNAMVKMLRHAKKRDILQLLQKAAGELVPFYIDAAVGAQ 359

  Fly   353 TFDAHNATFGFLYKESETTSEQLDLLEKYLQSLAVATHPDRKIVEHLFGLLEQESIKKHLKLRES 417
            :..:..|...||   ..:..:|:.|.||:|.|.|:|.||.::::.     |..|.:|.  |:.:.
Frog   360 SSASLAALSEFL---DFSKKKQVSLHEKFLYSAALAPHPTKEMLN-----LVLEKLKG--KVSDP 414

  Fly   418 VIQ---------TVATLTRQSGLDVEDPLLKEVRSYLLQGL----TSKEPTLYIRALQNLQDPAT 469
            ||.         .|..:.:....:::|  :...::.|::||    ...|..:|:.||:|.|.|.|
Frog   415 VIMETGIVVIGAIVGKMCKMKLCEIKD--VDIAKATLVEGLHEAEEESEIKIYLLALKNAQLPET 477

  Fly   470 IEALLEHA-QTGEAPNLSVAALQALKAFPLGSFNSSH-RLQFESIFYQRKRRFDSSARTLALDII 532
            |..||::| :.|.|  :|..||.||::||....::.. :.....||:|..:.:|.::|.:|.:|:
Frog   478 IPLLLQYAEENGGA--VSRKALAALQSFPTEMISTKEVKSTLRKIFHQTYQEYDKASRLIAAEIL 540

  Fly   533 LSLRPTQEQLGNFLDYLASNDRQFEIKTYVLQKLRMLAEKCPRFRALFKSELVKRRHVNNYNVLG 597
            |....:|..|.|.:  |...|...|....:|.|::...:...|.|...|: |:..:|:.||:.|.
Frog   541 LVTEHSQMDLINII--LGLEDINTEASKLLLSKIQRGQQIKNRLRKTEKT-LLTNKHLYNYSKLS 602

  Fly   598 QKGLTTVLTRQLSQAPAFNET----LLSTQEVYQGILKRGSVEFLLHAGRSQASSFKLGIYTAGL 658
            |.|.:|..:..|:.....:.|    ||.|:   .|:||:...:..|....:...:.::.|...||
Frog   603 QSGRSTFFSGPLTATKDVSSTYGLDLLFTE---SGLLKQSISDITLFGHNNHLKAMQVSIEAEGL 664

  Fly   659 GSLVGDGDSGDGNDAIPADDEFSEDEAVTAGMEISVQGAQLRPLVFFSGQTELMGHVWGGSASDS 723
            .||.|||          .||:..|.:..|.||...:...||||:|||.|..:|:..|: .|:.|.
Frog   665 ESLFGDG----------TDDDDDEHKDATVGMSAMLFDVQLRPVVFFQGYMDLVSKVF-SSSGDP 718

  Fly   724 TPAYQATTLSQDNEHYIILTSGATLHWRVLGARSVDLNGKVGFSLWNRNAQTEIQQNTGSAVLGH 788
            ....:...|..|....:.:.||........|...::::..:..|:|.:.::|.|  ||.::::
Frog   719 ISVVKGDVLLIDYLQRLPMQSGLQAIVEYQGGLGLEVSANIDVSIWEQESKTNI--NTKASLV-- 779

  Fly   789 LAVGFTYAKLVQDFSITHEPKLSLNAD--LDFYSGIK-------LCMQLQRPEQLLKQTNVRSVF 844
                |.:...|.......:.|..::|:  :||.|.:|       :|::|::.....::|.:.|..
Frog   780 ----FEFTTEVDTSFFQTDIKAQVDAETAVDFDSIMKFSSFPMLMCLELRQNNMPYRETYILSES 840

  Fly   845 LQSVDRPYAKHV--RSTLSHKTAGCTFALNQKNNEMC 879
            |...:..|.|..  ::||    .|..|..:..|:|||
Frog   841 LPEKNITYTKRKGRKATL----WGRDFPFHSSNSEMC 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtp	NP_610075.2	LPD_N	38..567	CDD:214755	152/553 (27%)
mttp.2	XP_002939768.2	Vitellogenin_N	32..566	CDD:421421	150/546 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4935
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I3408
OMA	1	1.010	-	-		QHG45382
OrthoDB	1	1.010	-	-		D299169at33208
OrthoFinder	1	1.000	-	-		FOG0006503
OrthoInspector	1	1.000	-	-		otm47453
Panther	1	1.100	-	-	LDO	PTHR13024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.080