DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sky and tbc1d24.1

DIOPT Version :9

Sequence 1:	NP_001260649.1	Gene:	sky / 35359	FlyBaseID:	FBgn0032901	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_012826017.1	Gene:	tbc1d24.1 / 780158	XenbaseID:	XB-GENE-981681	Length:	568	Species:	Xenopus tropicalis

Alignment Length:	601	Identity:	180/601 - (29%)
Similarity:	285/601 - (47%)	Gaps:	112/601 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GKEPALR--SYTEIQQLLQQGKKRDVKNILRENSWPINSPIRAQLWPMLCGQHQTKQQMLD-GFY 112
            |:|.:.:  |.|:.|         |:|.:.|:..|..:..:||:::..|..:...:....| ..|
Frog    19 GQEQSTKVLSCTDFQ---------DLKQMARQGHWAKSHSLRAKVYQKLIKEIPCRTVTPDASVY 74

  Fly   113 WEMVHQVFGTTELSEKPIMLPAFVDATHCLPYHLTSTGRAVADRIVNVLGYDCPDITYSPVLYPI 177
            .::|.::.|....|..|  ||.|||......|.|.|.|.....:|:..:....|||::.|.|..:
Frog    75 RDIVGKIVGKRPASSLP--LPEFVDDRQIPSYCLNSEGIGAVRKIITCISNQFPDISFCPALPSL 137

  Fly   178 TSILLHFMSEE-EAYICLAGLVGSKE--KVFINQTKLQHEVTWKTVMQIAKKHTKSATSYFQRIC 239
            .::|||:..:| |.:..::.::...:  :..::||.|..|.:..|...:|.|:.:........:.
Frog   138 VALLLHYSQDEAECFENVSRILACNDPNRRLVDQTFLAFESSCMTFGDLAGKYCQGPHKLMVAVS 202

  Fly   240 PGLKLERIFMDWCWWILAGLPFQHLVRIMDCYFHEGIKVLYRVALVILNLFHKECQSNNEWSPDN 304
            ..: || ::.||..||...|||.::.|:.|.:..||.|||:||||.:|..||| .:.......:|
Frog   203 EDV-LE-VYSDWQRWIFGELPFAYITRVFDVFLVEGYKVLFRVALALLKFFHK-VRGGQPMESNN 264

  Fly   305 IKNDIGNALIKFCKKIP--VSPAKLLHAAFSIRGLSTQYISRIFIKTEMLLKSRSVLTSGSKQLI 367
            :|.||.    .|.:.:.  |:|.|||..||:||..|.:.|..:.:..|..|:.:.:
Frog   265 VKRDIQ----MFVRDLNQCVAPEKLLEKAFAIRLFSRKEIQLLQMANEKALQQKGI--------- 316

  Fly   368 KSRSSDNLPTSQSQVNIQMMSHTLTIREKLHSESCRNLGEKSPGHRAIAMGVYPIHNLKSQACKN 432
                                    |:::|         ..:||..:.:.:.|: ..|.||:....
Frog   317 ------------------------TVKQK---------RVQSPVRQNVHLAVH-AENFKSEIVSV 347

  Fly   433 EDLFTLWSWLPVRITMYQPVLLYTTEEHGCSLTTFYVRVEQHEPTLLMIKTCNNEVFGAYCSSRW 497
            :::..:|||:|.|..:.||:||||..|||.||:.||:..|.||||||:|||.|.||.||:.|:.|
Frog   348 KEMRDIWSWIPERFALSQPLLLYTNREHGNSLSRFYLHCEGHEPTLLLIKTTNQEVCGAFLSTDW 412

  Fly   498 FERNVKDDKGQRQAYFGTGETFLFSLYPERAKYPWVGIE-----------GDKDL---------- 541
            .||.   ..|.:.::|||||.|:|.|.||..:|.||.|:           ||.|.
Frog   413 SERR---RSGNKLSFFGTGECFVFRLQPEVERYEWVVIKHPELGKVNASSGDNDANSSQSAKDGI 474

  Fly   542 ------------------GHSSELFMAADSKMITIGGGEGQAIWMDENIRFGKTDSCKTFNNPPL 588
                              ..|:.:|||..:..|.||||:|||::.|.::.:|:|..|.||||.||
Frog   475 DPSDRLSPFLATRHFNLPSKSASMFMAGSTDCIIIGGGDGQALYFDSDLNYGRTSHCNTFNNQPL 539

  Fly   589 CPSGDFEIRVLEVYGF 604
            | |..|:|.::||:||
Frog   540 C-SETFQISIIEVWGF 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sky	NP_001260649.1	RabGAP-TBC	82..293	CDD:382990	60/214 (28%)
sky	NP_001260649.1	TLDc	431..605	CDD:214733	85/213 (40%)
tbc1d24.1	XP_012826017.1	RabGAP-TBC	48..253	CDD:366170	58/208 (28%)
tbc1d24.1	XP_012826017.1	TLDc	342..554	CDD:214733	84/215 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7727
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27469
Inparanoid	1	1.050	269	1.000	Inparanoid score	I2948
OMA	1	1.010	-	-		QHG45915
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006083
OrthoInspector	1	1.000	-	-		otm47688
Panther	1	1.100	-	-	O	PTHR23353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4100
SonicParanoid	1	1.000	-	-		X4381
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100