DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sky and OXR1

DIOPT Version :9

Sequence 1:	NP_001260649.1	Gene:	sky / 35359	FlyBaseID:	FBgn0032901	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001185461.1	Gene:	OXR1 / 55074	HGNCID:	15822	Length:	874	Species:	Homo sapiens

Alignment Length:	578	Identity:	136/578 - (23%)
Similarity:	209/578 - (36%)	Gaps:	178/578 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PHVETSEIKTLDFYNLPKQTGKEPALRSYTEIQQLLQQGKKRDVKNILRENSWPINSPIRAQLWP 95
            |..||:|.|.....|..|| |||....|.||.::|                         .:||.
Human   470 PCGETAEFKQKQSVNKGKQ-GKEQNQDSQTEAEEL-------------------------RKLWK 508

  Fly    96 MLCGQHQTKQQMLDGFYWEMVHQVFGTTELSEKPIMLPAFVDATHCLPYHLTSTGRAVADRIVNV 160
            ....| |||||.      |.:.||      |:|        :|.|               :|.:.
Human   509 THTMQ-QTKQQR------ENIQQV------SQK--------EAKH---------------KITSA 537

  Fly   161 LGYDCPDITYSPVLYPITSILLHFMSEEEAYICLAGLVGS-KEKVFINQTKLQHEVTWKTVMQIA 224
            .|:    |..|.:|.......||      .::||.  ||. ..|.|::|.    ..|.:...|..
Human   538 DGH----IESSALLKEKQRHRLH------KFLCLR--VGKPMRKTFVSQA----SATMQQYAQRD 586

  Fly   225 KKHTKSATSYFQRICPGLKLERIFMDWCWWILAGLPFQHLVRIMDCYFHEGIKVLYRVALVILNL 289
            |||     .|                  |:.:......||                 .|..|
Human   587 KKH-----EY------------------WFAVPQERTDHL-----------------YAFFI--- 608

  Fly   290 FHKECQSNNEWSPDNIKNDIGNALIKFCKKIPVSPAKLLHAAFSIRGLSTQYISRIFIKTEMLLK 354
                     :|||:....|.|    ::.::......|.:..:.:|...|.|..:|.:....:...
Human   609 ---------QWSPEIYAEDTG----EYTREPGFIVVKKIEESETIEDSSNQAAAREWEVVSVAEY 660

  Fly   355 SRSVLTSGSKQLIKSRSSDNLPTSQSQVNIQMMSHTLTIREKLHSESCR-NLGEKSPGHRAIAMG 418
            .|.:....:::| ::.......|::..:|.:.::   |::..|.|||.| ||.:
Human   661 HRRIDALNTEEL-RTLCRRLQITTREDINSKQVA---TVKADLESESFRPNLSD----------- 710

  Fly   419 VYPIHNLKSQACKNEDLFTLWSWLPVRITMYQPVLLYTTEEHGCSLTTFY-VRVEQHEPTLLMIK 482
                   .|:....:.:..|...||.|...|...|:|.|.:||.||.|.| .......|.|::||
Human   711 -------PSELLLPDQIEKLTKHLPPRTIGYPWTLVYGTGKHGTSLKTLYRTMTGLDTPVLMVIK 768

  Fly   483 TCNNEVFGAYCSSRWFERNVKDDKGQRQAYFGTGETFLFSLYPERAKYPWVGIEGDKDLGHSSEL 547
            ..:.:||||..|.   ...|.|      .::||||||:|:..||...:.|.|         .:..
Human   769 DSDGQVFGALASE---PLKVSD------GFYGTGETFVFTFCPEFEVFKWTG---------DNMF 815

  Fly   548 FMAADSKMITIGGGEGQ-AIWMDENIRFGKTDSCKTFNNPPLCPSGDFEIRVLEVYGF 604
            |:..|...:..|||.|: |:|:|.::..|::.|||||.|..|....||.|:.:|::.|
Human   816 FIKGDMDSLAFGGGGGEFALWLDGDLYHGRSHSCKTFGNRTLSKKEDFFIQDIEIWAF 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sky	NP_001260649.1	RabGAP-TBC	82..293	CDD:382990	40/211 (19%)
sky	NP_001260649.1	TLDc	431..605	CDD:214733	58/176 (33%)
OXR1	NP_001185461.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..89
		LysM	<72..143	CDD:224306
		LysM	101..143	CDD:279777
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..194
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..406
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..537		31/128 (24%)
		Mediates oxidative antimutator activity	551..578		9/38 (24%)
		TLDc	712..874	CDD:214733	59/180 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5142
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810