Protein Alignment sky and tbc-7

DIOPT Version :10

• Sequence 1: NP_001260649.1
• Gene: sky / 35359
• FlyBaseID: FBgn0032901
• Length: 607
• Species: Drosophila melanogaster
• Sequence 2: NP_001359912.1
• Gene: tbc-7 / 180784
• WormBaseID: WBGene00016292
• Length: 679
• Species: Caenorhabditis elegans
• Alignment Length: 575
• Identity: 153/575 - (26%)
• Similarity: 248/575 - (43%)
• Gaps: 101/575 - (17%)

  Fly    60 TEIQQLLQQ-------GKKRDVKNILRENSWPINSPIRAQLWPMLCGQHQTKQQMLDGFYWEMVH 117
            :.:..|||:       .:...||.|:|...||:...|||.||..||   .||.       |....
 Worm   168 SSVPNLLQEIVDNKRLNRYEKVKKIIRRTDWPVCHEIRANLWKELC---NTKD-------WSGSK 222

  Fly   118 QVFGTTEL---------SEKPIMLPAFVDATHCLP-YHLTSTGRAVADRIVNVLGYDCPDITYSP 172
            :::....:         .:.|.:|   .|....|. :.|...|.....|::.::....|:|.|:|
 Worm   223 RLYSDEAIEYDRINQGKKQSPQIL---ADEGGVLSNFDLKEVGSVKLIRLLLIIERLRPEIVYAP 284

  Fly   173 VLYPITSILLHFMSEE-EAYICLAGLVGSKEKVFINQTKLQHEVTWKTVMQIAKKHTKSATSYFQ 236
            .:||:.|:||||..:: :.:.|:..|:.:|.  ::....:|...:..|::.:.|||..:|....:
 Worm   285 SIYPLCSLLLHFNDDDGDCFACINYLLNTKG--YLMTAPVQWAASSHTILALVKKHKSAAYVLLK 347

  Fly   237 R---ICPGLKLERIFMDWCWWILAGLPFQHLVRIMDCYFHEGIKVLYRVALVILNLFHKECQSNN 298
            |   ......|.:...||..|:...||..::.||:||||.||.|.|.|.|:.|:.::.|..:...
 Worm   348 RRLGTTDDSVLVKCIEDWLLWLFQYLPLPYICRIVDCYFAEGHKFLIRSAISIVYIWSKVHKRGM 412

  Fly   299 E--------WSPDNIKNDIGNALIKFCKKIPVSPAKLLHAAFSIRGLSTQYISRIFIKTEMLLKS 355
            |        ...|:||.:..:.    ...|.||.:..:..|..||.|.:..|:::..:.|..|
 Worm   413 EDFRGKSLQEKIDSIKKEFQDV----ATNISVSTSTFIATAVKIRNLQSATIAKLQAQFEDEL-- 471

  Fly   356 RSVLTSGSKQLIKSRSSDNLPTSQSQVNIQMMSHTLTIREKLHSESCRNLGEKSPGHRAIAMGVY 420
            |..:||..:|:.|                        :|..:..|:
 Worm   472 RDEVTSRPRQIKK------------------------VRRTIFCEA------------------- 493

  Fly   421 PIHNLKSQACKNEDLFTLWSWLPVRITMYQPVLLYTTEEHGCSLTTFYVRVEQHEPTLLMIKTCN 485
                .||....|:....|.|::|.|:.:..|.|.|...:.|.|...|:.:|:..:.|:::||:..
 Worm   494 ----FKSCLVDNDSAVELMSYMPPRLQLVTPTLAYQLSQDGTSFYNFWSKVDPLDQTIIIIKSTC 554

  Fly   486 NEVFGAYCSSRWFERNVKDDKGQRQAYFGTGETFLFSLYPERAK---YPWVGIEGDKDLGHSSEL 547
            ..:|||||||.|.||:.:.:: .|..|:||||:::|.:..|...   |.|||...|.......:.
 Worm   555 GAIFGAYCSSTWSERHDRKER-TRSKYWGTGESYVFRMNKEMELPEIYTWVGNSPDVSSDKCPQY 618

  Fly   548 FMAADSKMITIGGGEGQAIWMDENIRFGKTDSCKTFNNPPLCPSGDFEIRVLEVY 602
            ||:|..|...||.|...||.:||.:..|.|....|||:|.||..|.|:|..|||:
 Worm   619 FMSATDKSFVIGSGGRDAIRIDEELTHGITGPSSTFNSPQLCEDGAFDIYELEVF 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sky	NP_001260649.1	TBC	82..293	CDD:214540	59/224 (26%)
		TLDc	431..605	CDD:214733	63/175 (36%)
tbc-7	NP_001359912.1	TBC	196..409	CDD:214540	60/227 (26%)
		TLDc	498..672	CDD:214733	61/174 (35%)