DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sky and TLDC2

DIOPT Version :9

Sequence 1:	NP_001260649.1	Gene:	sky / 35359	FlyBaseID:	FBgn0032901	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_542195.1	Gene:	TLDC2 / 140711	HGNCID:	16112	Length:	215	Species:	Homo sapiens

Alignment Length:	178	Identity:	55/178 - (30%)
Similarity:	88/178 - (49%)	Gaps:	20/178 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 SQACKNEDLFTLWSWLPVRITMYQPVLLYTTEEHGCSLTTFYVRVEQ-HEPTLLMIKTCNNEVFG 490
            ||.....::..|....|.|:|.:...|::.|...|.||.:.|.|:|. ..|.||:::..:.::||
Human    53 SQVLSASEIRQLSFHFPPRVTGHPWSLVFCTSRDGFSLQSLYRRMEGCSGPVLLVLRDQDGQIFG 117

  Fly   491 AYCSSRWFERNVKDDKGQRQAYFGTGETFLFSLYPERAKYPWVGIEGDKDLGHSSELFMAADSKM 555
            |:.||.     ::..||    ::|||||||||..|:...:.|.|         |:..|:..|...
Human   118 AFSSSA-----IRLSKG----FYGTGETFLFSFSPQLKVFKWTG---------SNSFFVKGDLDS 164

  Fly   556 ITIGGGEGQ-AIWMDENIRFGKTDSCKTFNNPPLCPSGDFEIRVLEVY 602
            :.:|.|.|: .:|:|.::..|.:..|.||||..|.....|.|:.||.:
Human   165 LMMGSGSGRFGLWLDGDLFRGGSSPCPTFNNEVLARQEQFCIQELEAW 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sky	NP_001260649.1	RabGAP-TBC	82..293	CDD:382990
sky	NP_001260649.1	TLDc	431..605	CDD:214733	53/174 (30%)
TLDC2	NP_542195.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
TLDC2	NP_542195.1	TLDc	53..212	CDD:214733	55/176 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5142
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810