DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sky and tbc1d24

DIOPT Version :9

Sequence 1:	NP_001260649.1	Gene:	sky / 35359	FlyBaseID:	FBgn0032901	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_009295920.3	Gene:	tbc1d24 / 100536073	ZFINID:	ZDB-GENE-050809-65	Length:	610	Species:	Danio rerio

Alignment Length:	607	Identity:	164/607 - (27%)
Similarity:	264/607 - (43%)	Gaps:	122/607 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PALRSYTEIQQLLQQGKKRDVKNILRENSWPINSPIRAQLWPMLCGQHQTKQQMLDGFYWEMVHQ 118
            |....|.::::|.|..         |...|..|...|:.::..|......:....|.   |:...
Zfish    64 PGKTEYKDLKELKQHA---------RSGQWAKNHSQRSAVYQHLLKALPCRTVTPDA---EVYRD 116

  Fly   119 VFGTTELSEKP--IMLPAFVDATHCLPYHLTSTGRAVADRIVNVLGYDCPDITYSPVLYPITSIL 181
            :.|.:.....|  ..||.|||.|....|.|.:........:::.:....|||::.|.|..:|:::
Zfish   117 IVGNSTSKRNPSAYPLPEFVDGTAVPQYCLKAESIGSVHAVISCVAGQFPDISHCPSLPAVTALM 181

  Fly   182 LHFMSEE-EAYICLAGLVGSKE--KVFINQTKLQHEVTWKTVMQIAKKHTKSATSYFQRICPGLK 243
            :|:..:| :.:..::.::...|  :..::||.|.:|....|...:..|:..:|....  :.....
Zfish   182 MHWSPDEAQCFESVSRMLACNEPGRRLLDQTFLAYESACMTFGDLVHKYCPAAHKLM--VATATD 244

  Fly   244 LERIFMDWCWWILAGLPFQHLVRIMDCYFHEGIKVLYRVALVILNLFHKECQSNNEWSPDN---- 304
            :..::.||..|:...|||....|::|.:..||.||||||||.||..:.|:..::|. :|..
Zfish   245 VLEVYSDWQRWVFGDLPFSFAARVLDVFLVEGYKVLYRVALAILKFYRKQFVASNS-APSKQDSA 308

  Fly   305 -IKNDIGNALIKFCKKIPVSPAKLLHAAFSIRGLSTQYISRIFIKTEMLLKSRSVLTSGSKQLIK 368
             ::.||...:....|.  |:|.|||..|||||..|.:.|:.:.:..|..|:.:.:       .:|
Zfish   309 AVRRDIQTFVQSIGKS--VTPDKLLEKAFSIRLFSRKEITLLQLANEKSLQQKGI-------TVK 364

  Fly   369 SRSSDNLPTSQSQVNIQMMSHTLTIREKLHSESCRNLGEKSPGHRAIAMGVYPIHNLKSQACKNE 433
            .:||......|..||..                                      |..|:....:
Zfish   365 QKSSIKRQNVQLAVNAD--------------------------------------NFSSEIVSAK 391

  Fly   434 DLFTLWSWLPVRITMYQPVLLYTTEEHGCSLTTFYVRVEQHEPTLLMIKTCNNEVFGAYCSSRWF 498
            ::..:|||:|.|..:.||.||:||..|||||..||...|.:|||||:|:|.:.||.||:.|:.|.
Zfish   392 EIRDIWSWIPERFALCQPQLLFTTSTHGCSLNRFYAHCEGYEPTLLLIRTTDREVCGAFLSTDWE 456

  Fly   499 ERNVKDDKGQRQAYFGTGETFLFSLYPERAKYPWVGIE-----------------GDKDLGHSSE 546
            ||.   ..|.:.::|||||.|:|.:.||..:|.||.|:                 .|....||.|
Zfish   457 ERK---RGGNKLSFFGTGECFVFRMKPEMERYEWVIIKHPELAKSAQSAEDQSSVEDNGTPHSGE 518

  Fly   547 -----------------------------LFMAADSKMITIGGGEGQAIWMDENIRFGKTDSCKT 582
                                         :|||.:...|.||||:|.|:::|..:..|:|:.|.|
Zfish   519 TLEKPTTDSSHLSPFLSARHFNLNSRNTSMFMAGNVDSIIIGGGDGNALYIDSELNHGRTERCLT 583

  Fly   583 FNNPPLCPSGDFEIRVLEVYGF 604
            |:||||| :..|::.:|||:||
Zfish   584 FDNPPLC-AESFQVALLEVWGF 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sky	NP_001260649.1	RabGAP-TBC	82..293	CDD:382990	52/215 (24%)
sky	NP_001260649.1	TLDc	431..605	CDD:214733	79/220 (36%)
tbc1d24	XP_009295920.3	RabGAP-TBC	<157..295	CDD:306939	37/139 (27%)
tbc1d24	XP_009295920.3	TLDc	385..604	CDD:214733	78/222 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596636
Domainoid	1	1.000	80	1.000	Domainoid score	I8556
eggNOG	1	0.900	-	-		E1_COG5142
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27469
Inparanoid	1	1.050	226	1.000	Inparanoid score	I3471
OMA	1	1.010	-	-		QHG45915
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006083
OrthoInspector	1	1.000	-	-		oto39994
orthoMCL	1	0.900	-	-		OOG6_104315
Panther	1	1.100	-	-	LDO	PTHR23353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4100
SonicParanoid	1	1.000	-	-		X4381
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.830