Protein Alignment sky and tbc1d24.2

DIOPT Version :9

• Sequence 1: NP_001260649.1
• Gene: sky / 35359
• FlyBaseID: FBgn0032901
• Length: 607
• Species: Drosophila melanogaster
• Sequence 2: XP_031750506.1
• Gene: tbc1d24.2 / 100493941
• XenbaseID: XB-GENE-5957473
• Length: 616
• Species: Xenopus tropicalis
• Alignment Length: 618
• Identity: 177/618 - (28%)
• Similarity: 279/618 - (45%)
• Gaps: 161/618 - (26%)

  Fly    72 RDVKNILRENSWPINSPIRAQLWPMLCGQHQTKQQMLD-GFYWEMVHQVFGTTELSEKPIMLPAF 135
            :::|.:.||.:|.....:||:.:..:....:.:....| ..|.::..::||...:.:.  :||.|
 Frog    70 KELKRMAREGNWSNRRNLRAEAYNHIIKNIRCRSGTPDASVYHDVSERLFGRRGIQDH--LLPDF 132

  Fly   136 VDATHCLP--YHLTSTGRAVADRIVNVLGYDCPDITYSPVLYPITSILLHFMSEE-EAYICLAGL 197
            :|.  |||  |.|.:.|.....:::..:|...|||||||.|..:.::||||..:| |.:.....|
 Frog   133 LDG--CLPTVYCLNARGETAVKKVLICIGNQYPDITYSPSLPSVVALLLHFSEDEAECFERACRL 195

  Fly   198 VGSKE--KVFINQTKLQHEVTWKTVMQIAKKHTKSATSYFQRICP-GLKL--------ERIFMDW 251
            :...|  |.:::|:.|.:|.:..|...:|||:           || |.||        ..:|.||
 Frog   196 ISCTENHKCYVDQSFLAYEASCMTFGDLAKKY-----------CPAGHKLITTSCENSAEVFSDW 249

  Fly   252 CWWILAGLPFQHLVRIMDCYFHEGIKVLYRVALVILNLFHKECQSNNEWSPDNIKNDIGNALIKF 316
            ..||...|||::.:|:.|.:..||.||||||||.:|    |..:|:.|....::::||.:    |
 Frog   250 IMWIFGDLPFEYTIRVFDIFLIEGNKVLYRVALALL----KHYRSHLEHEVTDVRSDIQD----F 306

  Fly   317 CKKIP--VSPAKLLHAAFSIRGLSTQYISRIFIKTEMLLKSRSVLTSGSKQLIKSRSSDNLPTSQ 379
            .|.|.  :|..|||..||||         |:|...|:.|     |...:::.:..|.
 Frog   307 VKNISHHLSVQKLLEKAFSI---------RLFSHKELWL-----LQLANRKALSQRG-------- 349

  Fly   380 SQVNIQMMSHTLTIREKLHSESCRNLGEKSPGHRAIAMGVYPIHNLKSQACKNEDLFTLWSWLPV 444
                       :|:.:           .:.|.|.::     .:....|.....:::..:|||:|.
 Frog   350 -----------ITVMQ-----------PRQPAHMSV-----DLLEFSSVIVTAQEMRVIWSWIPE 387

  Fly   445 RITMYQPVLLYTTEEHGCSLTTFYVRVEQHEPTLLMIKTCNNEVFGAYCSSRWFERNVKDDKGQR 509
            |.::|.||||::|.|||.||..||...|..|||:|:|||...||.|::.||.|.||  :...||.
 Frog   388 RFSLYPPVLLFSTMEHGYSLQRFYSHCEGFEPTVLLIKTTGEEVCGSFLSSDWNER--RKCSGQV 450

  Fly   510 QAYFGTGETFLFSLYPERAKYPWVGIE-------------------------------------- 536
            ..||||||.|:||:.||..:|.||.::
 Frog   451 ATYFGTGECFVFSVRPEMERYEWVVVKKPELVKSAPPSPCSRPRSYSHGSRASTSPLRPSSPTLS 515

  Fly   537 ----------------GDKDLGH---------------SSELFMAADSKMITIGGGEGQAIWMDE 570
                            ||...|.               ::.:||:.:|..|.||||.|||:.:|.
 Frog   516 SAPSSPSPSPNFLTVPGDVSSGRLSPFLSVRHFQLPTKTASMFMSGNSSGIIIGGGGGQALNIDA 580

  Fly   571 NIRFGKTDSCKTFNNPPLCPSGDFEIRVLEVYG 603
            ::..|:|:.|:||:|||||.. :|.|:.:||:|
 Frog   581 DLNTGRTEPCETFDNPPLCQE-NFHIQHIEVWG 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sky	NP_001260649.1	RabGAP-TBC	82..293	CDD:382990	68/225 (30%)
		TLDc	431..605	CDD:214733	80/242 (33%)
tbc1d24.2	XP_031750506.1	RabGAP-TBC	144..292	CDD:366170	54/162 (33%)
		TLDc	372..614	CDD:214733	80/244 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7727
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	269	1.000	Inparanoid score	I2948
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006083
OrthoInspector	1	1.000	-	-		otm47688
Panther	1	1.100	-	-	LDO	PTHR23353
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4100
SonicParanoid	1	1.000	-	-		X4381
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.180