DRSC/TRiP Functional Genomics Resources

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Protein Alignment vari and Magi3

DIOPT Version :9

Sequence 1:NP_724288.3 Gene:vari / 35343 FlyBaseID:FBgn0250785 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_001152826.1 Gene:Magi3 / 99470 MGIID:1923484 Length:1476 Species:Mus musculus


Alignment Length:648 Identity:120/648 - (18%)
Similarity:205/648 - (31%) Gaps:224/648 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ARSRRQARQDKVELLARNNKVNGEDDTSDNAAFRNSTDL------SDHDEIFLK---GLLRSNSN 61
            ::.:|.....|:|.:  ::.:..|::..|..|...|..:      |:..:.::|   ...::||:
Mouse   220 SQRKRTTSVSKMERM--DSSLPEEEEDEDKEAVNGSGSMETREMHSETSDCWMKTVPSYNQTNSS 282

  Fly    62 TPHKELMLNPTEPQPVP------------LFLPAHLNNKP-------ICDDIIRKFSPSRRLESR 107
            ...:..|:.....:|:|            ::...| |.|.       :|    :|.......|..
Mouse   283 MDFRNYMMRDENLEPLPKNWEMAYTDTGMIYFIDH-NTKTTTWLDPRLC----KKAKAPEDCEDG 342

  Fly   108 ELA---KLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMP 169
            ||.   :.:..|.:          |..|...|.......:.:|.|.:::..|   ..::.:.|..
Mouse   343 ELPYGWEKIEDPQY----------GTYYVDHLNQKTQFENPVEEAKRKKQLG---QAEIHSAKTD 394

  Fly   170 VETIKMVGLRRDPSKPLGLTVEL-------------------DEFKQLVVARILAGGVIDKQSML 215
            ||.....   ||||:..|:.|..                   |||.|  |..:|..|...:...:
Mouse   395 VERAHFT---RDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQ--VKNVLKDGPAAQDGKI 454

  Fly   216 HVGDVILEVNG------TPVRTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNG 274
            ..||||:::||      |........|:.......||||..|..:.::.:.....:.......||
Mouse   455 APGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVING 519

  Fly   275 IASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDK 339
             .||..|:  ||.        .::|..|....:....|||.||                  .||:
Mouse   520 -QSLTKGE--TCM--------NTQDFKLGAMVLDQNGKSGQIL------------------ASDR 555

  Fly   340 IGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRM 404
            :. .||:..|:|                               .|:|:....:.||:        
Mouse   556 LN-GPSESSEQR-------------------------------ASLASSGSSQPELV-------- 580

  Fly   405 PPFRRKTLVLI-GVSGVGRRTLKNRLINSDVDKFGAVI---PHTSRPKRALEENGSSYWFMDREE 465
                  |:.|| |..|                 ||..|   |...:.|..|:    |.|.     
Mouse   581 ------TIPLIKGPKG-----------------FGFAIADSPTGQKVKMILD----SQWC----- 613

  Fly   466 MEEAVRNNEFLE--YGEHNGNLYGTHLQSIK---------DV----INSGRMCILDCAPNALKIL 515
              :.::..:.::  |.::..||  ||||.::         ||    :..|.......|.......
Mouse   614 --QGLQKGDIIKEIYHQNVQNL--THLQVVEVLKQFPVGADVPLLILRGGPCSPTKTAKTKTDTK 674

  Fly   516 HNSQEL----------MPFVIFVAAPGMEQL---------KTIYADRRATGSNRNLSFDRQSS 559
            .||..|          |||...:...|..:|         ||:|.|:.....:.::...:|.|
Mouse   675 ENSGSLETINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQES 737

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
variNP_724288.3 L27 <105..128 CDD:280918 4/25 (16%)
PDZ_signaling 173..250 CDD:238492 25/101 (25%)
SH3_MPP 287..347 CDD:212796 11/59 (19%)
Guanylate_kin 408..622 CDD:279019 38/190 (20%)
GuKc 418..622 CDD:214504 34/179 (19%)
Magi3NP_001152826.1 Interaction with ADRB1 and TGFA. /evidence=ECO:0000269|PubMed:15652357 18..108
PDZ_signaling 24..103 CDD:238492
NK 125..>199 CDD:302627
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..266 8/47 (17%)
WW 297..329 CDD:197736 5/32 (16%)
WW 345..375 CDD:238122 4/39 (10%)
Interaction with PTEN. /evidence=ECO:0000250 413..495 19/83 (23%)
PDZ 416..496 CDD:214570 19/81 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..575 9/73 (12%)
PDZ 578..659 CDD:214570 24/124 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 664..691 4/26 (15%)
PDZ 729..812 CDD:214570 2/9 (22%)
Interaction with ADGRB1. /evidence=ECO:0000250 729..811 2/9 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..844
PDZ_signaling 851..936 CDD:238492
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250 852..939
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..966
PDZ_signaling 1023..1101 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1109..1151
MIP-T3 <1166..>1431 CDD:287245
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1168..1476
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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