| Sequence 1: | NP_724288.3 | Gene: | vari / 35343 | FlyBaseID: | FBgn0250785 | Length: | 636 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001354650.1 | Gene: | CASK / 8573 | HGNCID: | 1497 | Length: | 926 | Species: | Homo sapiens |
| Alignment Length: | 628 | Identity: | 212/628 - (33%) |
|---|---|---|---|
| Similarity: | 331/628 - (52%) | Gaps: | 95/628 - (15%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 42 TDLSDHDEIFLKGLLRSNSNTPHKELMLN-----PTEPQPVPLFLPAHLNNKPI-----CDDIIR 96
Fly 97 KFS--PSRRLESRELAKLLAQPHFRALLRAHDEIG-ALY-EQRLKAAGGSTS-QLEIASQRQTGG 156
Fly 157 YLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVI 221
Fly 222 LEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNV---------DEEIKSGRYTVSGGQVKQNGI 275
Fly 276 ASLET-----GKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITA 335
Fly 336 ESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKR--KTMYRSVANCEFDKAELLLY 398
Fly 399 EEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDR 463
Fly 464 EEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFV 528
Fly 529 AAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQ 593
Fly 594 RKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| vari | NP_724288.3 | L27 | <105..128 | CDD:280918 | 12/22 (55%) |
| PDZ_signaling | 173..250 | CDD:238492 | 27/78 (35%) | ||
| SH3_MPP | 287..347 | CDD:212796 | 29/59 (49%) | ||
| Guanylate_kin | 408..622 | CDD:279019 | 82/213 (38%) | ||
| GuKc | 418..622 | CDD:214504 | 75/203 (37%) | ||
| CASK | NP_001354650.1 | STKc_CASK | 8..307 | CDD:270996 | |
| Calmodulin-binding | 305..315 | ||||
| L27 | 348..401 | CDD:197794 | 10/50 (20%) | ||
| L27 | 406..456 | CDD:397114 | 15/50 (30%) | ||
| Required for interaction with NRXN1 (via C-terminal tail). /evidence=ECO:0000250|UniProtKB:Q62915 | 482..909 | 171/476 (36%) | |||
| PDZ_signaling | 488..568 | CDD:238492 | 28/79 (35%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 574..610 | 5/35 (14%) | |||
| SH3_CASK | 616..677 | CDD:213014 | 29/60 (48%) | ||
| Guanylate_kin | 738..911 | CDD:395500 | 82/212 (39%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D364535at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.920 | |||||