Protein Alignment vari and Mpp2

DIOPT Version :9

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_008766350.1
• Gene: Mpp2 / 85275
• RGDID: 620014
• Length: 569
• Species: Rattus norvegicus
• Alignment Length: 642
• Identity: 238/642 - (37%)
• Similarity: 350/642 - (54%)
• Gaps: 105/642 - (16%)

  Fly     6 ARSRRQARQDKVELLARNNKVNGEDDTSDNAAFRNSTDLSDHDEIFLKGLLRS----NSNTPHKE 66
            |..||:|.|..::.|               .:..|:|..::.|.|||:|::.|    :....|:.
  Rat    22 AELRREAMQQVLDNL---------------GSLPNATGAAELDLIFLRGIMESPIVRSLAKAHER 71

  Fly    67 LMLNPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLES--RELAKLLAQPHFRALLRAHDEIG 129
              |..|:.:.|      ..||..:..:|:|..:......|  .|||::|.:|||::||..||.:.
  Rat    72 --LEETKLEAV------RDNNLELVQEILRDLAELAEQSSTAAELARILQEPHFQSLLETHDSVA 128

  Fly   130 A-LYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELD 193
            : .||....:.|                  ......|..:|.:.::|||:|:...:.||:|..:
  Rat   129 SKTYETPPPSPG------------------LDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRV- 174

  Fly   194 EFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRT-PDELQVEVSRAKENLTLKIGPNVDEE 257
            |..:||:||||.||::.:|.:|||||:|.||||.||.: |..||..:..|..::.|||.|:..|
  Rat   175 EGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPVGSDPRALQELLRSASGSVILKILPSYQE- 238

  Fly   258 IKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINV 322
                              ..|.....:.|:    |.|:|:.|||:||::.||.|.:||:|||:|.
  Rat   239 ------------------PHLPRQVFVKCH----FDYDPARDSLIPCKEAGLRFNAGDLLQIVNQ 281

  Fly   323 KDPNWWQAKNITAESDKIGLIPSQELEERRKAFVAPEADYVHKIG-ICGTRISKRKRKTMYRSVA 386
            .|.|||||.::  |....||||||.|||:|||||..:.:.....| :||:...|:|::.||.:..
  Rat   282 DDANWWQACHV--EGGSAGLIPSQLLEEKRKAFVKRDLELTPTSGTLCGSLSGKKKKRMMYLTTK 344

  Fly   387 NCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRAL 451
            |.|||:.|||:||||.||||||||||||||..|||||:|||:||..|.|::|..:|:|||..:..
  Rat   345 NAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLILWDPDRYGTTVPYTSRRPKDS 409

  Fly   452 EENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILH 516
            |..|..|.|:.|.|||..:|...:||:||:.||||||.:.||:.|:.||::|:||..|.|:|:|.
  Rat   410 EREGQGYSFVSRGEMEADIRAGRYLEHGEYEGNLYGTRIDSIRGVVASGKVCVLDVNPQAVKVLR 474

  Fly   517 NSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYE--D 579
            .: |.:|:|:|:.||..|.|:.:         ||                 ..|||..|..:  :
  Rat   475 TA-EFVPYVVFIEAPDFETLRAM---------NR-----------------AALESGVSTKQLTE 512

  Fly   580 DDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            .||..||||||.:||.|..|||:.:||.:.:.|||::...::::..|.|||||:|:|
  Rat   513 ADLRRTVEESSRIQRGYGHYFDLSLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	12/24 (50%)
		PDZ_signaling	173..250	CDD:238492	34/77 (44%)
		SH3_MPP	287..347	CDD:212796	29/59 (49%)
		Guanylate_kin	408..622	CDD:279019	90/215 (42%)
		GuKc	418..622	CDD:214504	81/205 (40%)
Mpp2	XP_008766350.1	L27	30..83	CDD:197794	14/75 (19%)
		L27	85..136	CDD:280918	16/50 (32%)
		PDZ_signaling	155..233	CDD:238492	35/78 (45%)
		SH3_MPP2	246..304	CDD:212970	30/63 (48%)
		Guanylate_kin	366..556	CDD:279019	90/216 (42%)
		GuKc	376..557	CDD:214504	81/207 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352367
Domainoid	1	1.000	61	1.000	Domainoid score	I10199
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	393	1.000	Inparanoid score	I1909
OMA	1	1.010	-	-		QHG48629
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	1	1.000	-	-		FOG0003013
OrthoInspector	1	1.000	-	-		otm45915
orthoMCL	1	0.900	-	-		OOG6_104327
Panther	1	1.100	-	-	O	PTHR23122
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2005
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910