DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vari and GUK1

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_010742.1	Gene:	GUK1 / 852065	SGDID:	S000002862	Length:	187	Species:	Saccharomyces cerevisiae

Alignment Length:	207	Identity:	63/207 - (30%)
Similarity:	99/207 - (47%)	Gaps:	30/207 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 KTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNE 474
            :.:|:.|.||.|:.||..:|.....|.||..:..|:|..||.|.||..|.|:..:|.:..::|||
Yeast     3 RPIVISGPSGTGKSTLLKKLFAEYPDSFGFSVSSTTRTPRAGEVNGKDYNFVSVDEFKSMIKNNE 67

  Fly   475 FLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTI 539
            |:|:.:.:||.||:.:.|:|.|..||:.||||.....:|.:....||....:|:|.|.:|.||.
Yeast    68 FIEWAQFSGNYYGSTVASVKQVSKSGKTCILDIDMQGVKSVKAIPELNARFLFIAPPSVEDLKK- 131

  Fly   540 YADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVI 604
                                 |...|...|.||:     :..|.|...|.::.:....   |.||
Yeast   132 ---------------------RLEGRGTETEESI-----NKRLSAAQAELAYAETGAH---DKVI 167

  Fly   605 VNEDFDETFRQV 616
            ||:|.|:.::::
Yeast   168 VNDDLDKAYKEL 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918
		PDZ_signaling	173..250	CDD:238492
		SH3_MPP	287..347	CDD:212796
		Guanylate_kin	408..622	CDD:279019	63/207 (30%)
		GuKc	418..622	CDD:214504	61/199 (31%)
GUK1	NP_010742.1	guanyl_kin	3..185	CDD:213788	63/207 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810