DRSC/TRiP Functional Genomics Resources

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Protein Alignment vari and CARD11

DIOPT Version :9

Sequence 1:NP_724288.3 Gene:vari / 35343 FlyBaseID:FBgn0250785 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_001311210.1 Gene:CARD11 / 84433 HGNCID:16393 Length:1154 Species:Homo sapiens


Alignment Length:675 Identity:136/675 - (20%)
Similarity:230/675 - (34%) Gaps:205/675 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 DLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQ-PVPLFLPAHLNNKPICDDIIRKFSPSRRLES 106
            |..|.||:....:|.|..|...:.|.:..|:.| ...:||.:.....|....::....|:||..:
Human    53 DEQDEDEVLNAPMLPSKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFST 117

  Fly   107 ---------------RELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQR---- 152
                           .|:.||..|...:.|.|.  |:.|    ||:.......|:.:....    
Human   118 IVVEEGHEGLTHFLMNEVIKLQQQMKAKDLQRC--ELLA----RLRQLEDEKKQMTLTRVELLTF 176

  Fly   153 QTGGYLFTE--DVLNTKMPVETIKMVGLRRDPSKPLGLT-VELDEFKQLVVARILAGGVIDKQSM 214
            |...|...|  |..|.    |.:|:    :|.:..|.:. .:|.|.|.:.|.|            
Human   177 QERYYKMKEERDSYND----ELVKV----KDDNYNLAMRYAQLSEEKNMAVMR------------ 221

  Fly   215 LHVGDVILEVNGTPVRTPDELQVEVSRAKE------NLTLKIGPNVDEEIKSGRYTVSGGQVKQN 273
              ..|:.||:        |:|:..:::.:|      |.:||:..:::            .:.|:.
Human   222 --SRDLQLEI--------DQLKHRLNKMEEECKLERNQSLKLKNDIE------------NRPKKE 264

  Fly   274 GIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESD 338
            .:..||...::      |.|.|....|::......||.....||.|:               |.|
Human   265 QVLELERENEM------LKTKNQELQSIIQAGKRSLPDSDKAILDIL---------------EHD 308

  Fly   339 -KIGLIPSQEL--------------EERRKAFVAPEAD--------------YVHKIGICGTRIS 374
             |..|...|||              ||.|..::..:.|              |.|::.....::.
Human   309 RKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLE 373

  Fly   375 --KRKRKTMYRS-------VANCEFDK-------AELLLYEEVTRMPPFRRKTLVLIGVSGVGR- 422
              :|:|...:.|       .:.|..:|       .||....:..|:...||:..::...|.:.| 
Human   374 EVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLESKLRRL 438

  Fly   423 ------------RTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNE- 474
                        |.|...:|:.|   ||...|.|         ||..  ..|....||:..::: 
Human   439 SKDSNNLDQSLPRNLPVTIISQD---FGDASPRT---------NGQE--ADDSSTSEESPEDSKY 489

  Fly   475 FLEY--GEHNGNLYGTHLQSIKDVINSGRMCIL----------DCAPN---ALKILHNSQELMP- 523
            ||.|  .:...||.|..||..|..|:..|....          |.:|:   :|.|.::..::.| 
Human   490 FLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGTDASPSSCGSLPITNSFTKMQPP 554

  Fly   524 ------FVIFVAAPGMEQLKTIY---ADRRATGSNRN-------LSFDRQSSIRFSSRRARTLES 572
                  ..|....||.:.:...|   |..|:|....|       |..|..|..|:|...: ::.|
Human   555 RSRSSIMSITAEPPGNDSIVRRYKEDAPHRSTVEEDNDSGGFDALDLDDDSHERYSFGPS-SIHS 618

  Fly   573 LASLYEDDDLVA-TVEESSFVQRKY 596
            .:|.::.:.|.| .:|:.:.:.||:
Human   619 SSSSHQSEGLDAYDLEQVNLMFRKF 643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
variNP_724288.3 L27 <105..128 CDD:280918 6/37 (16%)
PDZ_signaling 173..250 CDD:238492 16/83 (19%)
SH3_MPP 287..347 CDD:212796 13/60 (22%)
Guanylate_kin 408..622 CDD:279019 53/236 (22%)
GuKc 418..622 CDD:214504 51/226 (23%)
CARD11NP_001311210.1 CARD_CARD11_CARMA1 22..107 CDD:260070 13/53 (25%)
Linker. /evidence=ECO:0000305|PubMed:31296852 111..128 3/16 (19%)
BAR <173..>257 CDD:299863 23/113 (20%)
GBP_C <252..418 CDD:303769 33/198 (17%)
coiled coil 387..398 CDD:293879 1/10 (10%)
coiled coil 407..418 CDD:293879 2/10 (20%)
Inhibitory domain (ID). /evidence=ECO:0000303|PubMed:31296852 450..666 49/209 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 460..626 41/180 (23%)
PDZ_signaling 680..752 CDD:238492
SH3 777..839 CDD:302595
NK <1009..1143 CDD:302627
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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