DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and mpp3b

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_001340190.2	Gene:	mpp3b / 799884	ZFINID:	ZDB-GENE-121214-128	Length:	587	Species:	Danio rerio

Alignment Length:	643	Identity:	178/643 - (27%)
Similarity:	310/643 - (48%)	Gaps:	134/643 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SDHDE--IFLKGLLRSNSNT----PHKELMLNPTEPQPVPLFLPAHLNNKPIC--DDIIRKF-SP 100
            ::|.|  :||:.:....|.:    .|:.|       :...|:.|..:.:...|  :|:..:. :.
Zfish    25 ANHKEDLVFLREVFSERSLSYLMKIHERL-------RQFHLYSPTPVLHSASCLAEDVAEELQNG 82

  Fly   101 SRRLESRELAKLLAQPHFRALLRAHDEIGAL-YEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVL 164
            |...:.|||..||:.||.:|:|..||.:... :|..|......                     |
Zfish    83 SLEEDERELLALLSTPHIKAVLTVHDTVAQKNFEPVLPPLPND---------------------L 126

  Fly   165 NTKMPVETIKMVGLRRDPSKPLGLTVELDEFK-QLVVARILAGGVIDKQSMLHVGDVILEVNGTP 228
            ..::..|::|:|.|.:: .:|||.|:..||.. .:|||||:.||..|:..::||||.:.||||..
Zfish   127 EDELEEESVKIVRLVKN-KEPLGATIRRDEVTGAVVVARIMRGGAADRSGLVHVGDELREVNGNL 190

  Fly   229 V--RTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRAL 291
            :  :.|:|:...:|:::.::||||.|.:.||                     :..|:...|:|||
Zfish   191 IIHKRPEEISQILSQSQGSITLKIIPAIKEE---------------------DRFKESKVYLRAL 234

  Fly   292 FTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIPSQELEERRKAF- 355
            |.|.|.||...||::.||||..||:||:::..||.|||||.:...:.:.|||||::.:|||..:
Zfish   235 FDYTPYEDRATPCQEAGLPFLCGDVLQVVSQDDPTWWQAKRVGDSNLRAGLIPSRQFQERRLLYR 299

  Fly   356 ---------VAPEA----------DYVHKIGICGT---------RISKRKRKTMYRSVANCEFDK 392
                     .:|.|          |...:..:.|.         |:|::..:...:.....|..:
Zfish   300 MKMGTHQSPKSPRATPCDQTCEKEDCDSESSVSGQHVAGLRRSFRLSRKDHQGSNKESHTPESTE 364

  Fly   393 AELLLYEEVT----RMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEE 453
            .|.|:|||||    |:.. :.:.:||||..|.....||.::|..:..::|..:|||:||:::.|:
Zfish   365 NEFLIYEEVTLHQMRLQD-KPRLVVLIGSLGARINELKQKVIAENPQRYGVAVPHTTRPRKSHEK 428

  Fly   454 NGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNS 518
            .|..|.|:.::..:..:::|:|:||||:..|.|||.|:||:.|:...::|::|..|.|||||..|
Zfish   429 EGVEYHFISKQAFDADIQSNKFIEYGEYKNNQYGTSLESIRSVLARNKVCLVDVQPEALKILRTS 493

  Fly   519 QELMPFVIFVAAPGMEQLKTIYADRRAT------GSNRNLSFDRQSSIRFSSRRARTLESLASLY 577
             |..|:|||| .|.:.:::.    .|::      |.|.:::
Zfish   494 -EFKPYVIFV-KPRIPEIRR----HRSSPTSPERGDNGHIT------------------------ 528

  Fly   578 EDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWI 635
             ::||:.....:..::::|....|.|::.||......::...|:::..|.|||||:|:
Zfish   529 -EEDLLDMKHSAEQMEQQYGHLVDRVLIKEDSASACVELRLILERLEREPQWVPVSWV 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	11/22 (50%)
		PDZ_signaling	173..250	CDD:238492	30/79 (38%)
		SH3_MPP	287..347	CDD:212796	31/59 (53%)
		Guanylate_kin	408..622	CDD:279019	59/219 (27%)
		GuKc	418..622	CDD:214504	55/209 (26%)
mpp3b	XP_001340190.2	L27	11..55	CDD:280918	7/36 (19%)
		L27	69..119	CDD:280918	15/49 (31%)
		PDZ_signaling	135..215	CDD:238492	31/80 (39%)
		SH3	230..291	CDD:302595	31/60 (52%)
		Guanylate_kin	383..571	CDD:279019	58/218 (27%)
		GuKc	400..571	CDD:214504	53/201 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594322
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840