DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and dlg5

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_004916076.1	Gene:	dlg5 / 779611	XenbaseID:	XB-GENE-978275	Length:	1971	Species:	Xenopus tropicalis

Alignment Length:	627	Identity:	135/627 - (21%)
Similarity:	228/627 - (36%)	Gaps:	176/627 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 NPTEPQPVPLFLPAHLNNKPICD--DIIRKFSPS--RRLESRELAKL-----LAQPHF--RALLR 123
            |.||.|       |.|.....||  .|:.:::|:  :.:.||..::|     .:.||.  .|...
Frog  1452 NATEQQ-------ARLIIGQQCDTITILAQYNPNMCQHIHSRSSSRLDTSTTHSTPHSSGAATPD 1509

  Fly   124 AHDEIGALYEQ-------RLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRD 181
            .|..|..:.||       ..|.:..|||..........|....:|           :::|.|.:.
Frog  1510 NHSIIDTVSEQDEGTMTPPSKESTPSTSPCSSLRTNAEGIKRHSE-----------LRVVTLSKS 1563

  Fly   182 PSKPLGLTV---------ELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPV--RTPDEL 235
            |.| ||:.:         .||..::.||     ||::.       ||::||.....:  ||.:|.
Frog  1564 PEK-LGIQICGGNLHGIFVLDIEEENVV-----GGLLK-------GDMVLEYGSVDMRNRTAEEA 1615

  Fly   236 QVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYN---PS 297
            .:|:.:..||:.:|:...:||..|.......|                  .|:|||:...   ||
Frog  1616 YLEMLKPAENIKVKVQQKIDEFNKLKDLPGDG------------------FYIRALYDRQAELPS 1662

  Fly   298 EDSLLPCRDIGLPFKSGDILQIINVKDP---NWWQAKNITAESDKI--GLIPS-----QELEERR 352
            |          |.||..|||.:.:....   ..|.|..:...:.|:  |.:||     ||...|.
Frog  1663 E----------LSFKKDDILYVDDTLPQGTFGTWMAWQLDENAQKLQRGQVPSKYMMEQEFSRRL 1717

  Fly   353 KAFVAPEADYVHKIGICGTRISKRKRKTMYR----------------SVANCEF-DKAELLLYEE 400
            ......:.....|......|.|..:||..::                |..:..| |::..|.|:.
Frog  1718 SMSEGRDETMASKTLSAAARRSFFRRKNKHKRSGSRDGKDLQGLDTISTDSIPFLDESVSLAYQR 1782

  Fly   401 VTRMPPFRRKTLVLIG--VSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDR 463
            |.|:.....:.::::|  |..|     |:.|:.....||         .:..||...:|     :
Frog  1783 VQRVDCTSPRPVLILGPLVDAV-----KDMLVKESPGKF---------CRCPLEVMKAS-----Q 1828

  Fly   464 EEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFV 528
            :.:|..|::..|::|...:|:...|.:.|||::......|:||.||:|::.|| |..:.|.|:|:
Frog  1829 QAIERGVKDCLFIDYKRRSGHFDVTTVASIKEITEKDCHCLLDIAPHAIERLH-SVHIYPIVLFI 1892

  Fly   529 AAPGMEQLK----TIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEES 589
            .....:|:|    .|:...:.|..:....|                                |.:
Frog  1893 RYKSTKQIKEQKDPIFLRDKVTQKHSKEQF--------------------------------ETA 1925

  Fly   590 SFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVP 631
            ..::::|.|||..||..........|:...:||...:..|:|
Frog  1926 HKIEQEYSKYFTAVIQGGALFSICNQICSIVDQEQSKALWIP 1967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	7/29 (24%)
		PDZ_signaling	173..250	CDD:238492	22/87 (25%)
		SH3_MPP	287..347	CDD:212796	19/72 (26%)
		Guanylate_kin	408..622	CDD:279019	44/219 (20%)
		GuKc	418..622	CDD:214504	42/207 (20%)
dlg5	XP_004916076.1	CARD	9..88	CDD:260018
		Takusan	127..213	CDD:368141
		Smc	<136..544	CDD:224117
		COG4372	443..>672	CDD:226809
		PDZ_signaling	697..784	CDD:238492
		PDZ_signaling	798..867	CDD:238492
		PDZ	1395..1477	CDD:214570	9/31 (29%)
		dbPDZ_assoc	1475..1554	CDD:374667	16/78 (21%)
		PDZ	1554..1633	CDD:214570	24/102 (24%)
		SH3_DLG5	1649..1711	CDD:212794	19/71 (27%)
		GuKc	1784..1960	CDD:214504	47/227 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910