Protein Alignment vari and Mpp7

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_011245327.1
• Gene: Mpp7 / 75739
• MGIID: 1922989
• Length: 601
• Species: Mus musculus
• Alignment Length: 608
• Identity: 186/608 - (30%)
• Similarity: 302/608 - (49%)
• Gaps: 119/608 - (19%)

  Fly    76 PVPLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAG 140
            |:|:...|......:.:::..|...|   |.|||.|||::|:.:|||..||.:
Mouse    65 PLPILHGAAALADDLTEELQNKLPNS---EIRELLKLLSKPNVKALLSVHDTV------------ 114

  Fly   141 GSTSQLEIASQRQTGGYL--FTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDE-FKQLVVAR 202
                     :|:.....|  ..:|:.:.:..|:.|::|    ..|:|||.|::.|| ...:.|||
Mouse   115 ---------AQKSYDPVLPPVPDDIDDEEDSVKIIRLV----KNSEPLGATIKKDEQTGAITVAR 166

  Fly   203 ILAGGVIDKQSMLHVGDVILEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTV 265
            |:.||..|:..::||||.:.||||.||  :.|:|:...:|::|..:|.||.|:..||..|
Mouse   167 IMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIKILSQSKGAITFKIIPSTKEETPS----- 226

  Fly   266 SGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQA 330
                         :.||   .:::|||.|:|.||..:||::.||.|:.||||||::..|..||||
Mouse   227 -------------KEGK---IFIKALFDYDPKEDKAIPCKEAGLSFRKGDILQIMSQDDVTWWQA 275

  Fly   331 KNITAESDKIGLIPSQELEERRKAFVAPE------------------------ADYVHKIGICGT 371
            |:....:.:.|||||:..:|||.|...||                        .|..|.....||
Mouse   276 KHEGDANPRAGLIPSKHFQERRLALRRPEIVVQPLKLSNTKSYEETVECEEIKEDTGHDGNNSGT 340

  Fly   372 RIS--------KRKRKTMYRSVANC----EFDKAELLLYEEVTRMPPFRR------KTLVLIGVS 418
            .|:        .||.|.:.:|:..|    ::|.|::..|||||   |:||      :.:||:|..
Mouse   341 YIAGFRRSFRLSRKNKKINKSMYECKKSEQYDTADVPTYEEVT---PYRRQIHDKYRLIVLVGPV 402

  Fly   419 GVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNG 483
            |||...||.:|:.||...:|.::|||:|.:|:.|.:|..|.|:.:...|..|:||:|:||||:..
Mouse   403 GVGLNELKRKLLMSDAQHYGVIVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKN 467

  Fly   484 NLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGS 548
            |.|||.:.|::.|:...::|:||..|:.:|.| .:.|..|:|||:..|.:|:|       |.|..
Mouse   468 NYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHL-RTLEFKPYVIFIKPPSIERL-------RETRK 524

  Fly   549 NRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETF 613
            |..:...|..            :..|..:.::|....::.:..::.:|...||.:|:|:|....|
Mouse   525 NAKIISSRDD------------QGTAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAF 577

  Fly   614 RQVVETLDQMSHEEQWVPVNWIY 636
            .::..|.|::..:..||||:|::
Mouse   578 NELKTTFDKLETDTHWVPVSWLH 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	13/22 (59%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	32/80 (40%)
		SH3_MPP	287..347	CDD:212796	29/59 (49%)
		Guanylate_kin	408..622	CDD:395500	66/219 (30%)
Mpp7	XP_011245327.1	L27	16..68	CDD:197794	1/2 (50%)
		L27	75..125	CDD:197794	17/73 (23%)
		PDZ_MPP3-MPP4-MPP7-like	138..218	CDD:467260	33/83 (40%)
		SH3_MPP7	232..292	CDD:212966	29/59 (49%)
		GuKc	403..588	CDD:214504	62/204 (30%)