DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vari and Lrguk

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_006506776.1	Gene:	Lrguk / 74354	MGIID:	1921604	Length:	1341	Species:	Mus musculus

Alignment Length:	665	Identity:	133/665 - (20%)
Similarity:	236/665 - (35%)	Gaps:	206/665 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 ELMLNPTEPQPV---PLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDE 127
            :.:|:.||.|..   |.| |..|.:|          ...|...|..|.:|:.:.|         |
Mouse    28 QAILSLTEKQSQGRWPSF-PLGLKSK----------GTFRSASSYLLHQLIHRSH---------E 72

  Fly   128 IGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVEL 192
            ..|..|::.:..|.|....|...|.....|   :.:|..:...|.|..:|.....::.:.|.:.|
Mouse    73 AEAEQEEKQQEDGESEESEESEMQNLEDKY---DGILREETVAEAITGLGWSGRGTEQVYLNLNL 134

  Fly   193 DEFKQLVVARILAGGV-----------IDKQSMLHVGDVILEVNGTP--------VRTPDEL-QV 237
            ... :||...||.|.|           |:..|.:.....:||:|.:.        .:.|..| :|
Mouse   135 SHC-ELVDISILCGYVHLQKLNLSGNRIEDLSCVSCMPYLLELNASQNKLTTFFNFKPPQNLKKV 198

  Fly   238 EVS----------RAKENLTLKIGPNVDEEIKSG--------RYTVSGGQVK------------- 271
            :.|          .|...||..|..|.:.|..:|        ..:::|.::.
Mouse   199 DFSSNLISEMYDLSAYHTLTQLILDNNEIEEITGLENCISLTHLSLAGNKITTIKGLGTLPIKVL 263

  Fly   272 --QNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNIT 334
              .|.:....||.:   .::||...:.|.:.:...:.:    ::.|:|::||::|
Mouse   264 SLSNNMIETITGLE---ELKALQNLDLSHNQISSLQGL----ENHDLLEVINLED---------- 311

  Fly   335 AESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRK-----------TMYRSVANC 388
               :||     :||.         |.:|:..:.|  .|:....|.           .:|..:...
Mouse   312 ---NKI-----KELS---------EIEYIENLPI--LRVLNLLRNPIQTKPEYWFFVIYMLLRLT 357

  Fly   389 EFDKAELLLYEEV----------------------------------TRMP----PFRRKTLVLI 415
            |.|:.::.:.|:|                                  :.:|    |:  ..|:|.
Mouse   358 ELDQQKIKVEEKVFAVNKYDPPPEVVAVQDHMTHVVNSMSQPQRIWDSTLPSLDAPY--PMLILT 420

  Fly   416 GVSGVGRRTLKNRLIN--SDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFL-- 476
            |.:..|:|.|.:||..  |...::||.  ||:||....|.:...|.|:.:|..:|.:...:|:
Mouse   421 GPAACGKRELAHRLCRQFSTYFRYGAC--HTTRPPYFGEGDRVDYHFISQEVFDEMLNMGKFILT 483

  Fly   477 -EYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIY 540
             .||.||   ||.:..:|:.:...|   :..|       :|...|           |:..||..|
Mouse   484 FNYGNHN---YGLNRDTIEGIARDG---LASC-------IHMELE-----------GVRSLKYSY 524

  Fly   541 ADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIV 605
            .:.|..   ..:..|::....:..|:     .|.|..|.:..|:.|:....|.:||..|||.||.
Mouse   525 FEPRYI---LVVPMDKEKYEGYLRRK-----GLFSRAEIEIAVSRVDLYVKVNQKYPGYFDAVIN 581

  Fly   606 NEDFDETFRQVVETL 620
            .:|.|..::::.|.:
Mouse   582 ADDMDIAYQKLSELI 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	4/22 (18%)
		PDZ_signaling	173..250	CDD:238492	22/106 (21%)
		SH3_MPP	287..347	CDD:212796	10/59 (17%)
		Guanylate_kin	408..622	CDD:279019	55/218 (25%)
		GuKc	418..622	CDD:214504	52/208 (25%)
Lrguk	XP_006506776.1	leucine-rich repeat	131..150	CDD:275380	6/19 (32%)
		internalin_A	<132..>333	CDD:380193	43/237 (18%)
		leucine-rich repeat	151..172	CDD:275380	2/20 (10%)
		leucine-rich repeat	173..194	CDD:275380	4/20 (20%)
		leucine-rich repeat	195..216	CDD:275380	4/20 (20%)
		leucine-rich repeat	217..238	CDD:275380	6/20 (30%)
		leucine-rich repeat	258..281	CDD:275380	3/25 (12%)
		leucine-rich repeat	282..300	CDD:275380	2/21 (10%)
		leucine-rich repeat	304..328	CDD:275380	10/50 (20%)
		GMPK	416..537	CDD:238026	37/149 (25%)
		PHA03247	<678..1233	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810