DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Dlg5

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_017171686.1	Gene:	Dlg5 / 71228	MGIID:	1918478	Length:	1931	Species:	Mus musculus

Alignment Length:	671	Identity:	139/671 - (20%)
Similarity:	243/671 - (36%)	Gaps:	206/671 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SRRQARQ------DKVELLARNN----KVNGEDDTS---DNAAFRNSTDLSDHDEIFLKGLLRSN 59
            :.:|||.      |.:.:||:.|    ::|....:|   |.||..:||         |:|   |:
Mouse  1416 TEQQARLIIGQQCDTITILAQYNPHIHQLNSHSRSSSHLDPAATPHST---------LQG---SS 1468

  Fly    60 SNTPHKELMLNP-TEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLR 123
            :.||....:::| .|....|...||             |.|.|......:..|....|....:.:
Mouse  1469 AGTPEHPSVIDPLMEQDEGPGTPPA-------------KQSASSTRSVGDTTKKTPDPRIVFIKK 1520

  Fly   124 AHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSK-PLG 187
            :..::|      :...||:...:.:|.         .||                 ..|:| |.|
Mouse  1521 SQLDLG------VHLCGGNLHGVFVAE---------VED-----------------DSPAKGPDG 1553

  Fly   188 LTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPV--RTPDELQVEVSRAKENLTLKI 250
            |.                           .||:|||.....:  ||.:::.||:.:.|::|.||:
Mouse  1554 LV---------------------------PGDLILEYGSLDMRSRTVEDVYVEMLKPKDSLRLKV 1591

  Fly   251 GPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGD 315
                  :.:...:|    :||  |:    .|...  |:|||:      |.|... :..|.||..|
Mouse  1592 ------QYRHEEFT----RVK--GL----PGDSF--YIRALY------DRLAEV-EPELSFKKDD 1631

  Fly   316 ILQIINVKDP---NWWQAKNITAESDKI--GLIPSQELEE----RRKAFVAPEADYVHKIGICGT 371
            ||.:.:....   ..|.|..:...:.||  |.|||:.:.:    ||.:....:.|...|......
Mouse  1632 ILYVDDTLPQGVFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNTAKTLSAAA 1696

  Fly   372 RISKRKRKTMYRSVANCE-----------------FDKAELLLYEEVTRMPPFRRKTLVLIGVSG 419
            |.|..:||..::...:.:                 |:.:..|.|:.|.::.....:.::|:|..
Mouse  1697 RRSFFRRKHKHKRSGSKDGKDLLALDTFSNDSIPLFEDSVSLAYQRVQKVDCTSLRPVLLLGPL- 1760

  Fly   420 VGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGN 484
              ...:|..|:|....||         .:..||...:|     ::.:|..|::..|::|...:|:
Mouse  1761 --LDVVKEMLVNEAPGKF---------CRCPLEVMKAS-----QQAIERGVKDCLFVDYKRRSGH 1809

  Fly   485 LYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFV----AAPGMEQLKTIYADRRA 545
            ...|.:.|||::....|.|:||.||:|::.||: ..:.|.|||:    |....||...:|...:.
Mouse  1810 FDVTTVASIKEITEKNRHCLLDIAPHAIERLHH-MHIYPIVIFIRYKSAKHIKEQRDPVYLRDKV 1873

  Fly   546 TGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFD 610
            |        .|.|..:|                        |.:..:.::|.:||..|:......
Mouse  1874 T--------QRHSKEQF------------------------ETAQKIDQEYSRYFTGVVQGGALS 1906

  Fly   611 ETFRQVVETLDQMSHEEQWVP 631
            ....|::..:.|...:..|:|
Mouse  1907 SICTQILAMVSQEQSKVLWIP 1927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	2/22 (9%)
		PDZ_signaling	173..250	CDD:238492	17/79 (22%)
		SH3_MPP	287..347	CDD:212796	20/64 (31%)
		Guanylate_kin	408..622	CDD:279019	46/217 (21%)
		GuKc	418..622	CDD:214504	44/207 (21%)
Dlg5	XP_017171686.1	Takusan	129..213	CDD:368141
		Smc	<141..564	CDD:224117
		PDZ_signaling	625..712	CDD:238492
		PDZ_signaling	<741..800	CDD:238492
		PDZ	1357..1439	CDD:214570	6/22 (27%)
		dbPDZ_assoc	1437..1512	CDD:374667	22/99 (22%)
		PDZ	1513..1594	CDD:214570	25/145 (17%)
		SH3_DLG5	1610..1672	CDD:212794	20/68 (29%)
		GuKc	1744..1920	CDD:214504	47/225 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810