DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Mpp1

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001032748.1	Gene:	Mpp1 / 652956	RGDID:	1594331	Length:	467	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	171/514 - (33%)
Similarity:	264/514 - (51%)	Gaps:	85/514 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 EQRLKAAGGSTSQLEIASQRQTGGYLFTE---DVLNTKMPVETIKMVGLRRDPSKPLGLTVEL-D 193
            ||.|:..||...  |..|.|...|.:.|.   |:...:.....:::|...:. ::|:|:|::| |
  Rat    29 EQLLRNRGGRGD--EAQSDRAEDGAVRTNGSVDLGEEEEAARGVRVVRFEKS-AEPMGITLKLND 90

  Fly   194 EFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNVDE 256
            :.....|||||.||...:|..|||||.|||:|||.|  |:.|:||..:...:..::||:.|.
  Rat    91 KAASCTVARILHGGAAHRQGSLHVGDEILEINGTDVTGRSVDQLQRAMKETRGTISLKVIPR--- 152

  Fly   257 EIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIIN 321
                          :|:.:.:|:      .::||.|.|:|.:|.|:||::.||.|.:||::|:||
  Rat   153 --------------QQSRLPALQ------MFVRAQFDYDPQKDDLIPCKEAGLAFSTGDVIQVIN 197

  Fly   322 VKDPNWWQAKNITAESDKIGLIPSQELEERRKAF---VAP-EADYVHKIGICGTRISKRKRKTMY 382
            ..|.||||.:.........||:||.||:|.|.|.   ||| ||......|      .|:|.|..|
  Rat   198 KDDGNWWQGRVQGNARGSAGLLPSPELQEWRAASAAQVAPAEAPSCSPFG------KKKKCKDKY 256

  Fly   383 RSVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRP 447
            .:..:..||:.:::.||||.|:|.|:||||||||.|||||..:||.|:..:.::|....|||:||
  Rat   257 LAKHSAIFDRLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNALLAQNPERFAYPAPHTTRP 321

  Fly   448 KRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNAL 512
            .|..|.:|:.|.|:..|||...:..|||||:|...|:::||.|.:::.:...|::.:||..|..|
  Rat   322 PRKGEADGAEYHFVSAEEMARGIAANEFLEFGSFRGDMFGTRLDAVRRIHECGQVAVLDIEPQTL 386

  Fly   513 KILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLY 577
            |.:..: ||.||::|:|.                                :.:.|.| |:|..|.
  Rat   387 KAVRTA-ELSPFIVFIAP--------------------------------TDQGAET-EALRQLR 417

  Fly   578 EDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            .|.|.         ::.:|...||:.:|:...|||..::.|..|:...:.|||||:|:|
  Rat   418 ADSDA---------IRGRYAHLFDLCLVHNGVDETLGRLCEAFDRACADPQWVPVSWVY 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918
		PDZ_signaling	173..250	CDD:238492	31/79 (39%)
		SH3_MPP	287..347	CDD:212796	26/59 (44%)
		Guanylate_kin	408..622	CDD:279019	67/213 (31%)
		GuKc	418..622	CDD:214504	59/203 (29%)
Mpp1	NP_001032748.1	PDZ	80..150	CDD:278991	31/69 (45%)
		SH3_MPP1	163..224	CDD:213013	26/60 (43%)
		Guanylate_kin	282..452	CDD:279019	67/212 (32%)
		GuKc	292..455	CDD:214504	60/205 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010