DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Dlg2

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_038945240.1	Gene:	Dlg2 / 64053	RGDID:	619895	Length:	1026	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	180/728 - (24%)
Similarity:	306/728 - (42%)	Gaps:	185/728 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SRRQARQDKVELLARNNKVNGEDDTSDNAA--FRNSTDLSDHDEIFLK----------------- 53
            :::..|....:.|...|..:.|:.|.:.|.  .:|::|:     ::||
  Rat   375 AQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDV-----VYLKVGKPTTIYMTDPYGPPD 434

  Fly    54 -----------GLLRSNSNTPHKELMLNPTEP---QPVPLFL-----------PAHLNNKPICDD 93
                       .||..|:.|...:..|.|..|   .|:|..:           |.:.....:||
  Rat   435 ITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTRPPEPVYSTVNKLCD- 498

  Fly    94 IIRKFSPSRRLESRELAK--LLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGG 156
              :..|| |.....|..|  ||:.|:      .|..:|.|.:          |.:...||..|.
  Rat   499 --KPASP-RHYSPVECDKSFLLSTPY------PHYHLGLLPD----------SDMTSHSQHSTA- 543

  Fly   157 YLFTEDVLNTKMPVETI-KMVGLRRDPSKPL------GLTVEL---DEFKQLVVARILAGGVIDK 211
                     |:.|..|: :.:.|..:|.|.:      ||...:   ::.:.:.|:.|||||..|.
  Rat   544 ---------TRQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADL 599

  Fly   212 QSMLHVGDVILEVNGTPVRTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQ---- 272
            ...|..||.||.|||..:|.....|...:......|:.|......| ...|:......:::
  Rat   600 SGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPE-DYARFEAKIHDLREQMMN 663

  Fly   273 ----NGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNI 333
                :|..||.|.:|.:.|:||:|.|:.|:||.||.:  ||.||.||||.:||..|..||||:.:
  Rat   664 HSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRV 726

  Fly   334 --TAESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRIS---KRKRKTMYR---------- 383
              ..:|:::|:|||:...||::........:..|.|:..::.|   |||:..::.
  Rat   727 ILDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKE 791

  Fly   384 -------------------SVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRL 429
                               |.::|...:..:|.||.|||......:.::::|       .:|:|
  Rat   792 QSEQETSDPEQHVSSNASDSESSCRGQEDLILSYEPVTRQEINYTRPVIILG-------PMKDR- 848

  Fly   430 INSDV-----DKFGAVIPHTSRPKRALEENGSSYWF-MDREEMEEAVRNNEFLEYGEHNGNLYGT 488
            ||.|:     ||||:.:|||:||||..|.:|..|.| :.||:||:.::.::|:|.|::|.|||||
  Rat   849 INDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGT 913

  Fly   489 HLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLS 553
            .:||::.|...|:.||||.:.||:|.|..:| |.|..||:....:|.|..:  ::|.|......:
  Rat   914 SVQSVRFVAERGKHCILDVSGNAIKRLQVAQ-LYPIAIFIKPKSLEPLMEM--NKRLTEEQAKKT 975

  Fly   554 FDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVE 618
            :||...:                                ::::.:||..::..:..::.:.|...
  Rat   976 YDRAIKL--------------------------------EQEFGEYFTAIVQGDTLEDIYNQCKL 1008

  Fly   619 TLDQMSHEEQWVP 631
            .:::.|....|:|
  Rat  1009 VIEEQSGPFIWIP 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	6/24 (25%)
		PDZ_signaling	173..250	CDD:238492	23/86 (27%)
		SH3_MPP	287..347	CDD:212796	30/61 (49%)
		Guanylate_kin	408..622	CDD:279019	60/219 (27%)
		GuKc	418..622	CDD:214504	59/209 (28%)
Dlg2	XP_038945240.1	L27_1	2..62	CDD:401120
		MAGUK_N_PEST	157..239	CDD:402306
		PDZ_signaling	240..324	CDD:238492
		PDZ_signaling	333..418	CDD:238492	9/47 (19%)
		PDZ_assoc	420..487	CDD:402299	9/66 (14%)
		PDZ_signaling	561..639	CDD:238492	22/77 (29%)
		SH3_DLG2	676..749	CDD:212965	33/74 (45%)
		Guanylate_kin	835..1013	CDD:395500	60/220 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810