DRSC/TRiP Functional Genomics Resources

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Protein Alignment vari and MPP4

DIOPT Version :9

Sequence 1:NP_724288.3 Gene:vari / 35343 FlyBaseID:FBgn0250785 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_149055.2 Gene:MPP4 / 58538 HGNCID:13680 Length:637 Species:Homo sapiens


Alignment Length:652 Identity:172/652 - (26%)
Similarity:279/652 - (42%) Gaps:183/652 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 TPHKELML---------NPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPH 117
            |||.:::.         .||.|                              |.:||.::|..||
Human    84 TPHAQVLSYEVVELLRETPTSP------------------------------EIQELRQMLQAPH 118

  Fly   118 FRALLRAHDEIGAL-YEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRD 181
            |:|||.|||.|... :|..|.....:..:.|                       |.:::|.|.::
Human   119 FKALLSAHDTIAQKDFEPLLPPLPDNIPESE-----------------------EAMRIVCLVKN 160

  Fly   182 PSKPLGLTVELDEFK-QLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRTPDELQV--EVSRAK 243
             .:|||.|::..|.. .::||||:.||:.::..:|:.||.::||||..|...|..||  .::.::
Human   161 -QQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSR 224

  Fly   244 ENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIG 308
            ..:..|:.|..|..:.|.:..                      |:||:..|.|.||..:||.|.|
Human   225 GTIMFKVVPVSDPPVNSQQMV----------------------YVRAMTEYWPQEDPDIPCMDAG 267

  Fly   309 LPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIP----------------------------- 344
            |||:.||||||::..|..||||:.|:..:...||:|                             
Human   268 LPFQKGDILQIVDQNDALWWQARKISDPATCAGLVPSNHLLKRKQREFWWSQPYQPHTCLKSTLS 332

  Fly   345 ------------------------SQELEERRKAFVAPEADYVHKIGICGTRISKR--KRKT--- 380
                                    |:||.|.::.||.    |..|..|.|.|.|.|  :||:   
Human   333 ISMEEEDDMKIDEKCVEADEETFESEELSEDKEEFVG----YGQKFFIAGFRRSMRLCRRKSHLS 393

  Fly   381 -MYRSV---ANCEFDKAELLLYEEVT---RMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFG 438
             ::.||   .:|.  .|....||||.   |.|..:.:.:||:|.||||...|:.:||..:...|.
Human   394 PLHASVCCTGSCY--SAVGAPYEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQ 456

  Fly   439 AVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMC 503
            :.:|||:|.|::.|.||..|.::.:|..|..:.::..|||||:.|:||||.:.:::.|:..|::|
Human   457 SAVPHTTRTKKSYEMNGREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKIC 521

  Fly   504 ILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRAR 568
            ::|..|..::.: .:.||.|:|||:....|..:|       .:..|..:..|....::|.....:
Human   522 VMDLEPQDIQGV-RTHELKPYVIFIKPSNMRCMK-------QSRKNAKVITDYYVDMKFKDEDLQ 578

  Fly   569 TLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVN 633
            .:|:||...|               .::.::||.||||:...:...|::..:.:...|.||||..
Human   579 EMENLAQRME---------------TQFGQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPAT 628

  Fly   634 WI 635
            ||
Human   629 WI 630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
variNP_724288.3 L27 <105..128 CDD:280918 13/22 (59%)
PDZ_signaling 173..250 CDD:238492 24/79 (30%)
SH3_MPP 287..347 CDD:212796 30/112 (27%)
Guanylate_kin 408..622 CDD:279019 59/213 (28%)
GuKc 418..622 CDD:214504 56/203 (28%)
MPP4NP_149055.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
L27 30..83 CDD:197794
L27 90..140 CDD:197794 19/79 (24%)
PDZ_signaling 153..232 CDD:238492 25/79 (32%)
SH3_MPP4 246..306 CDD:212967 29/59 (49%)
Guanylate_kin 428..618 CDD:331880 59/212 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158387
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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