DRSC/TRiP Functional Genomics Resources

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Protein Alignment vari and MPP4

DIOPT Version :10

Sequence 1:NP_724288.3 Gene:vari / 35343 FlyBaseID:FBgn0250785 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_149055.2 Gene:MPP4 / 58538 HGNCID:13680 Length:637 Species:Homo sapiens


Alignment Length:652 Identity:172/652 - (26%)
Similarity:279/652 - (42%) Gaps:183/652 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 TPHKELML---------NPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPH 117
            |||.:::.         .||.|                              |.:||.::|..||
Human    84 TPHAQVLSYEVVELLRETPTSP------------------------------EIQELRQMLQAPH 118

  Fly   118 FRALLRAHDEIGAL-YEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRD 181
            |:|||.|||.|... :|..|.....:..:.|                       |.:::|.|.::
Human   119 FKALLSAHDTIAQKDFEPLLPPLPDNIPESE-----------------------EAMRIVCLVKN 160

  Fly   182 PSKPLGLTVELDEFK-QLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRTPDELQV--EVSRAK 243
             .:|||.|::..|.. .::||||:.||:.::..:|:.||.::||||..|...|..||  .::.::
Human   161 -QQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSR 224

  Fly   244 ENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIG 308
            ..:..|:.|..|..:.|.:..                      |:||:..|.|.||..:||.|.|
Human   225 GTIMFKVVPVSDPPVNSQQMV----------------------YVRAMTEYWPQEDPDIPCMDAG 267

  Fly   309 LPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIP----------------------------- 344
            |||:.||||||::..|..||||:.|:..:...||:|                             
Human   268 LPFQKGDILQIVDQNDALWWQARKISDPATCAGLVPSNHLLKRKQREFWWSQPYQPHTCLKSTLS 332

  Fly   345 ------------------------SQELEERRKAFVAPEADYVHKIGICGTRISKR--KRKT--- 380
                                    |:||.|.::.||.    |..|..|.|.|.|.|  :||:   
Human   333 ISMEEEDDMKIDEKCVEADEETFESEELSEDKEEFVG----YGQKFFIAGFRRSMRLCRRKSHLS 393

  Fly   381 -MYRSV---ANCEFDKAELLLYEEVT---RMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFG 438
             ::.||   .:|.  .|....||||.   |.|..:.:.:||:|.||||...|:.:||..:...|.
Human   394 PLHASVCCTGSCY--SAVGAPYEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQ 456

  Fly   439 AVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMC 503
            :.:|||:|.|::.|.||..|.::.:|..|..:.::..|||||:.|:||||.:.:::.|:..|::|
Human   457 SAVPHTTRTKKSYEMNGREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKIC 521

  Fly   504 ILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRAR 568
            ::|..|..::.: .:.||.|:|||:....|..:|       .:..|..:..|....::|.....:
Human   522 VMDLEPQDIQGV-RTHELKPYVIFIKPSNMRCMK-------QSRKNAKVITDYYVDMKFKDEDLQ 578

  Fly   569 TLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVN 633
            .:|:||...|               .::.::||.||||:...:...|::..:.:...|.||||..
Human   579 EMENLAQRME---------------TQFGQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPAT 628

  Fly   634 WI 635
            ||
Human   629 WI 630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
variNP_724288.3 L27 <105..128 CDD:460717 13/22 (59%)
PDZ_MPP6-MPP2-like 174..252 CDD:467268 25/80 (31%)
SH3_MPP 287..347 CDD:212796 30/112 (27%)
Guanylate_kin 408..622 CDD:395500 59/213 (28%)
MPP4NP_149055.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
L27 30..83 CDD:197794
L27 90..140 CDD:197794 19/79 (24%)
PDZ_MPP3-MPP4-MPP7-like 153..233 CDD:467260 25/80 (31%)
SH3_MPP4 246..306 CDD:212967 29/59 (49%)
Guanylate_kin 428..618 CDD:395500 59/212 (28%)
Blue background indicates that the domain is not in the aligned region.

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