Protein Alignment vari and mpp3a

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_021330373.1
• Gene: mpp3a / 572079
• ZFINID: ZDB-GENE-130530-555
• Length: 613
• Species: Danio rerio
• Alignment Length: 677
• Identity: 185/677 - (27%)
• Similarity: 306/677 - (45%)
• Gaps: 168/677 - (24%)

  Fly    47 HDEI-FLKGLLRSNSNTPHKELM---------------------LNPTEPQ-PVPLFLPAHLNNK 88
            |:.: .|...||.::|  |||.|                     |...|.| |.|:...|    .
Zfish    15 HETLALLTSQLRPDAN--HKEDMVFLRDVFSERSLSCLMKIHEKLRQYEKQSPTPVLHSA----S 73

  Fly    89 PICDDIIRKF-SPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQR 152
            .:.:|:..:. |....:|.:||..||..||.:|:|..||.:                     :|:
Zfish    74 TLAEDVAEELQSGPMSVEEKELLHLLTSPHLKAVLSVHDTV---------------------AQK 117

  Fly   153 QTGGYL-FTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFK-QLVVARILAGGVIDKQSML 215
            .....| ...|....::..|::|:|.|.:: .:|||.|:..||.. .::||||:.||..|:..::
Zfish   118 NFDPVLPPLPDDFEDELDEESVKIVRLVKN-KEPLGATIRRDESTGAVIVARIMKGGAADRSGLV 181

  Fly   216 HVGDVILEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASL 278
            ||||.:.||||:.|  :.|||:...:|:::.::||||.|.:.||.|          :::|.:
Zfish   182 HVGDELREVNGSSVMHKRPDEISQLLSQSQGSITLKIIPAIKEEDK----------LQENKV--- 233

  Fly   279 ETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLI 343
                    ||||||.|.|.||...||::.|||||.||:||:::..|..|||||.|...:.:.||:
Zfish   234 --------YMRALFDYTPLEDKATPCQEAGLPFKRGDVLQVVSQDDQTWWQAKRIGDCNLRAGLV 290

  Fly   344 PSQELEERRKAF---------------------------------------------VAPEADYV 363
            ||::.:|||.|:                                             |||....|
Zfish   291 PSKQFQERRLAYRIKMGTLQNSKSPKKAVYDQGCDKEDCDCEGYFNGQYIVSSKCNAVAPSCGQV 355

  Fly   364 -----HKIGICGT-RISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPP---FRRKTLVLIGVSG 419
                 :..|:..: |:|::.|:.........:.:..:.|.||||||...   .|.:.:||||..|
Zfish   356 FSWDFYSAGLRRSFRLSRKDRRGSSGEANVSDQNDTDFLTYEEVTRYQQRSNERPRLVVLIGSLG 420

  Fly   420 VGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGN 484
            .....||.::|..:..::...:|||:|||::.|:.|..|.|:.::..:...:||:|:||||:..|
Zfish   421 ARINELKQKVIAENPHRYAVAVPHTTRPKKSHEKEGVEYHFVTKQAFDADAQNNKFIEYGEYKEN 485

  Fly   485 LYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRAT--- 546
            ||||.:::|:.|....:||::|..|.|||.|..: |..|:||||.....|..:     ||:.
Zfish   486 LYGTSIEAIRSVQAKNKMCLVDVQPEALKALRTA-EFKPYVIFVKPKIPESRR-----RRSAATS 544

  Fly   547 ---GSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNED 608
               |.:..::.:....:|.|:::                         :.::|....|.|::.||
Zfish   545 PGGGEHGRITEEDLQEMRLSAQQ-------------------------IDQQYGHLVDRVLIKED 584

  Fly   609 FDETFRQVVETLDQMSHEEQWVPVNWI 635
            ......::...|:::..|..|||::|:
Zfish   585 TASASTELRSILERLERETFWVPISWV 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	11/22 (50%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	33/80 (41%)
		SH3_MPP	287..347	CDD:212796	32/59 (54%)
		Guanylate_kin	408..622	CDD:395500	59/219 (27%)
mpp3a	XP_021330373.1	L27	15..66	CDD:460717	12/52 (23%)
		L27	73..123	CDD:460717	14/70 (20%)
		PDZ_MPP3-MPP4-MPP7-like	140..220	CDD:467260	33/80 (41%)
		SH3	234..295	CDD:473055	32/60 (53%)
		GuKc	426..597	CDD:214504	52/201 (26%)