DRSC/TRiP Functional Genomics Resources

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Protein Alignment vari and Pals2

DIOPT Version :9

Sequence 1:NP_724288.3 Gene:vari / 35343 FlyBaseID:FBgn0250785 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_001158205.1 Gene:Pals2 / 56524 MGIID:1927340 Length:553 Species:Mus musculus


Alignment Length:620 Identity:236/620 - (38%)
Similarity:348/620 - (56%) Gaps:102/620 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 NSTDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPLFLPAHL------------NNKPICD 92
            :||...:.|.|||||            :|.||.    |.....||.            ||..:.:
Mouse    13 SSTGAEEIDLIFLKG------------IMENPI----VKSLAKAHERLEDSKLEAVSDNNLELVN 61

  Fly    93 DIIRKFSPSRRLESR--ELAKLLAQPHFRALLRAHDEIGA-LYEQRLKAAGGSTSQLEIASQRQT 154
            :|:...:|...::..  ||..:|.:|||::||.|||.:.: .|:     :..|:.::.|.|    
Mouse    62 EILEDITPLISVDENVAELVGILKEPHFQSLLEAHDIVASKCYD-----SPPSSPEMNIPS---- 117

  Fly   155 GGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGD 219
                     ||.::||:.|:::|:.:...:|||:|..: |...||:||||.||:||:|.:|||||
Mouse   118 ---------LNNQLPVDAIRILGIHKKAGEPLGVTFRV-ENNDLVIARILHGGMIDRQGLLHVGD 172

  Fly   220 VILEVNGTPV-RTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVS----GGQVKQNGIASLE 279
            :|.||||..| ..|.|||..:.....::||||.|:..:.|...:..|:    ...|:|       
Mouse   173 IIKEVNGHEVGNNPKELQELLKNISGSVTLKILPSYRDTITPQQSYVNMERHPAHVRQ------- 230

  Fly   280 TGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIP 344
                  .:::..|.|||..|:|:||::.||.|..|:||||:|.:|||||||.:: .|....||||
Mouse   231 ------VFVKCHFDYNPFNDNLIPCKEAGLKFSKGEILQIVNREDPNWWQASHV-KEGGSAGLIP 288

  Fly   345 SQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRR 409
            ||.|||:|||||  ..|:.:....|||..:|:|:|.||.:..|.|||:.|:.:||||.:||||:|
Mouse   289 SQFLEEKRKAFV--RRDWDNSGPFCGTISNKKKKKMMYLTTRNAEFDRHEIQIYEEVAKMPPFQR 351

  Fly   410 KTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNE 474
            |||||||..|||||:||||.|..:..:||..:|.|||..|..|::|.:|.|:.|.|||..::..:
Mouse   352 KTLVLIGAQGVGRRSLKNRFIVLNPARFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGK 416

  Fly   475 FLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTI 539
            :||:||:.||||||.:.||.:|:.:||.||||..|.|||:|..| |.||:|:|:|||.:|.|:.:
Mouse   417 YLEHGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTS-EFMPYVVFIAAPELETLRAM 480

  Fly   540 Y---ADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFD 601
            :   .|...|                           ..|..|.||..||:||:.:||.|..|||
Mouse   481 HKAVVDAGIT---------------------------TKLLTDSDLKKTVDESARIQRAYNHYFD 518

  Fly   602 MVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            ::|||::.|:.|.::...::::..|.||||::|:|
Mouse   519 LIIVNDNLDKAFEKLQTAIEKLRMEPQWVPISWVY 553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
variNP_724288.3 L27 <105..128 CDD:280918 11/24 (46%)
PDZ_signaling 173..250 CDD:238492 35/77 (45%)
SH3_MPP 287..347 CDD:212796 30/59 (51%)
Guanylate_kin 408..622 CDD:279019 89/216 (41%)
GuKc 418..622 CDD:214504 81/206 (39%)
Pals2NP_001158205.1 L27 2..55 CDD:197794 14/57 (25%)
L27 57..108 CDD:397114 14/55 (25%)
PDZ_signaling 132..205 CDD:238492 34/73 (47%)
SH3_MPP6 232..292 CDD:212971 31/60 (52%)
Guanylate_kin 350..540 CDD:395500 89/217 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848779
Domainoid 1 1.000 61 1.000 Domainoid score I10410
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H22976
Inparanoid 1 1.050 396 1.000 Inparanoid score I1949
Isobase 1 0.950 - 0 Normalized mean entropy S2251
OMA 1 1.010 - - QHG48629
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003013
OrthoInspector 1 1.000 - - otm43830
orthoMCL 1 0.900 - - OOG6_104327
Panther 1 1.100 - - LDO PTHR23122
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2005
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.710

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