DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vari and dlg3

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_021328515.1	Gene:	dlg3 / 564081	ZFINID:	ZDB-GENE-050208-93	Length:	940	Species:	Danio rerio

Alignment Length:	723	Identity:	179/723 - (24%)
Similarity:	302/723 - (41%)	Gaps:	194/723 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLARNN----KVNGEDDTSDNAAFRNSTDLSDHDEIFLK----GLLRSN---------------- 59
            |||.||    .|..|:..   ||.:|::|:     ::||    |.:..|
Zfish   297 LLAVNNIILQDVRHEEAV---AALKNTSDM-----VYLKVAKPGPVHLNDMYAPPDYSSSLGLPP 353

  Fly    60 -------SNTPHKELMLNPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPH 117
                   ::..|...|......:|.|::.|..:...        ::||..|....|.....|:|.
Zfish   354 AFPTMVDNHVGHNSSMAYMGGMEPKPVYQPPQVTPS--------RYSPVPRHMLGEEDFTRAEPI 410

  Fly   118 FRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMP----VETIKMVGL 178
            :.|:.:.|              |.::........|.:|      ||..:..|    ...:...|
Zfish   411 YSAIHKPH--------------GDTSPPSPHLCSRGSG------DVGCSPAPPALCQSLVPYTG- 454

  Fly   179 RRDPSKPL------GLTVEL---DEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVR--TP 232
             |:|.|.|      ||...:   ::.:.:.|:.|||||..|....|..||.||.|||..:|  |.
Zfish   455 -REPRKILLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATH 518

  Fly   233 DELQVEVSRAKENLTL--KIGP----NVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRAL 291
            ::....:.||.:.:|:  :..|    ..:.:|...|..:....: .:|..||.|.:|.:.|:|||
Zfish   519 EQAAAALKRAGQTVTIIAQYRPEEYSRFESKIHDLREQMMNSSM-SSGSGSLRTSEKRSLYVRAL 582

  Fly   292 FTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNIT--AESDKIGLIPSQ-------- 346
            |.|:.:.||.||.:  ||.|..||||.:||..|..||||:.:|  .||::||:|||:
Zfish   583 FDYDRTRDSCLPSQ--GLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRYSTANR 645

  Fly   347 ---ELEER----------RKAFVAPEADYVHKIG-ICGTRISKRK-----RK-TMYRSVANCEFD 391
               |.:||          |...:....:...::. |...::.::|     || ..|:|..|...:
Zfish   646 PGVEKKERARLKTVKFHARTGMIESNREMFGRMNDIRPVKVKRKKSFNLSRKFPFYKSKENIVQE 710

  Fly   392 KAE----------------------LLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDV 434
            ..|                      :|.||.|.|......:.::::|       .:|:| :|.|:
Zfish   711 LVETEQCLTSNTSDSESSSKGQEDTILSYEPVIRQEIHYTRPVIILG-------PMKDR-VNDDL 767

  Fly   435 -----DKFGAVIPHTSRPKRALEENGSSYWFM-DREEMEEAVRNNEFLEYGEHNGNLYGTHLQSI 493
                 .|||:.:|||:||:|..|.:|..|.|: .||:||:.:::|:|:|.|:.|.|||||.:.|:
Zfish   768 ISEFPHKFGSCVPHTTRPRRENEMDGQDYHFVGSREQMEKDIQDNKFIEAGQFNENLYGTSILSV 832

  Fly   494 KDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQS 558
            :.|...|:.||||.:.||:|.|..:| |.|..||:....:|.|..:  ::|.|....|..||:..
Zfish   833 RAVAERGKHCILDVSGNAIKRLQQAQ-LYPIAIFIKPKSVEALMEL--NKRQTYEQANKVFDKAM 894

  Fly   559 SIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQM 623
            .:                                ::::.::|..::..:..||.:.::...:::.
Zfish   895 KL--------------------------------EQEFGEFFTAIVQGDSLDEIYNKIKLIIEEQ 927

  Fly   624 SHEEQWVP 631
            |....|:|
Zfish   928 SGPYIWIP 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	5/22 (23%)
		PDZ_signaling	173..250	CDD:238492	27/89 (30%)
		SH3_MPP	287..347	CDD:212796	32/72 (44%)
		Guanylate_kin	408..622	CDD:279019	58/219 (26%)
		GuKc	418..622	CDD:214504	57/209 (27%)
dlg3	XP_021328515.1	MAGUK_N_PEST	<109..149	CDD:313762
		PDZ_signaling	150..234	CDD:238492
		PDZ_signaling	243..329	CDD:238492	13/39 (33%)
		PDZ_assoc	330..409	CDD:313755	12/86 (14%)
		PDZ	456..540	CDD:214570	25/83 (30%)
		SH3_DLG3	575..639	CDD:212962	32/65 (49%)
		Guanylate_kin	749..927	CDD:279019	58/220 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810