Protein Alignment vari and mpp2a

DIOPT Version :9

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001314719.1
• Gene: mpp2a / 562207
• ZFINID: ZDB-GENE-071004-82
• Length: 547
• Species: Danio rerio
• Alignment Length: 611
• Identity: 229/611 - (37%)
• Similarity: 340/611 - (55%)
• Gaps: 84/611 - (13%)

  Fly    30 DDTSDNAAFRNSTDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPLFLPAHLNNKPICDDI 94
            |..||:.   :||..:|.|.|||||::.|    |.....|..|..:.|      ..||..:..||
Zfish    17 DTLSDST---SSTTANDLDLIFLKGIMES----PVSAESLEETRLEAV------RDNNVELVQDI 68

  Fly    95 IRKFSP--SRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGY 157
            :|:.||  .|...:.||:::|.||||::||..||.:.:                :..........
Zfish    69 LRELSPFTHRSNTAAELSRILNQPHFQSLLETHDSVAS----------------QTCESPPPSPC 117

  Fly   158 LFTEDVLNT-KMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVI 221
            .|.|..::| ::|.:.|:|||:|:.|.:.||:|..: |..:||:||||.||:||:|.:|||||:|
Zfish   118 AFMEPPISTAQVPADAIRMVGIRKVPGEHLGVTFRI-ENGELVIARILHGGMIDQQGLLHVGDII 181

  Fly   222 LEVNGTPV-RTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLT 285
            .||||..| ..|..||..:.....|:.|||.|:..|.....:..|                 |..
Zfish   182 KEVNGREVGDDPRVLQEVLQETSGNIVLKILPSYQEPHPPRQVFV-----------------KCH 229

  Fly   286 CYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIPSQELEE 350
            |      .|:|:.|:|:||::.||.|.|||||||:|.:|.|||||:::  |....||||||.|||
Zfish   230 C------DYDPANDNLIPCKEAGLMFSSGDILQIVNQEDVNWWQARHV--EGGSAGLIPSQLLEE 286

  Fly   351 RRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRRKTLVLI 415
            :|||||..:.:......:|...:.|:|:|.||.:..|.:||:.|||:||||.::||||||||:||
Zfish   287 KRKAFVKRDVELSPAANLCSGMVGKKKKKMMYLTTKNADFDRHELLIYEEVAKVPPFRRKTLILI 351

  Fly   416 GVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGE 480
            |..|||||:|||:|:.||...:|..||:|||..::.:.....|.|..|.:||..::...:||:||
Zfish   352 GAPGVGRRSLKNKLLVSDPQHYGVTIPYTSRKAKSADRENMMYAFTSRSKMEADIKAGRYLEHGE 416

  Fly   481 HNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRA 545
            ::|||||..:.||.:|:.:||:||||..|..||:|..| |.:|:|:|:.||..|.||.:    ..
Zfish   417 YDGNLYGIKIDSIHEVVEAGRICILDVNPQTLKVLRTS-EFLPYVVFIKAPEFEVLKAM----NR 476

  Fly   546 TGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFD 610
            :|....::..|::                    |.:|..|:|||:.:||.|..|||:.|||:|.:
Zfish   477 SGIEAGVATKRKT--------------------DAELKKTIEESAKIQRVYGHYFDLTIVNDDLE 521

  Fly   611 ETFRQVVETLDQMSHEEQWVPVNWIY 636
            |.:..:..:|:::...:|||||.|::
Zfish   522 EAYSTLKSSLEKLKGVQQWVPVGWVF 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	11/22 (50%)
		PDZ_signaling	173..250	CDD:238492	37/77 (48%)
		SH3_MPP	287..347	CDD:212796	29/59 (49%)
		Guanylate_kin	408..622	CDD:279019	82/213 (38%)
		GuKc	418..622	CDD:214504	74/203 (36%)
mpp2a	NP_001314719.1	L27	62..113	CDD:308467	17/66 (26%)
		PDZ_signaling	134..212	CDD:238492	38/78 (49%)
		SH3	225..283	CDD:327375	32/82 (39%)
		Guanylate_kin	344..534	CDD:331880	82/214 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594304
Domainoid	1	1.000	60	1.000	Domainoid score	I10546
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1911
OMA	1	1.010	-	-		QHG48629
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	1	1.000	-	-		FOG0003013
OrthoInspector	1	1.000	-	-		otm25584
orthoMCL	1	0.900	-	-		OOG6_104327
Panther	1	1.100	-	-	O	PTHR23122
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2005
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910