DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment vari and Pals1

DIOPT Version :9

Sequence 1:NP_724288.3 Gene:vari / 35343 FlyBaseID:FBgn0250785 Length:636 Species:Drosophila melanogaster
Sequence 2:NP_062525.1 Gene:Pals1 / 56217 MGIID:1927339 Length:675 Species:Mus musculus


Alignment Length:688 Identity:193/688 - (28%)
Similarity:328/688 - (47%) Gaps:139/688 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 RSRRQARQDKVEL----------LARNNKVNGED----DTSDNAAFRN---STDLSDHDEIF--L 52
            |.||:....|.||          ||:.....|.|    ||.:.....:   :.::.|.:::|  |
Mouse    67 RRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPIFDTEEGIVLESPHYAVNILDVEDLFSSL 131

  Fly    53 KGLLRS-----------------------NSNTPHKELMLNPTEPQPVPLFLPAHLNNKPICDDI 94
            |.:..:                       |:...|..:.::.::..|.   .|...|.:.:..::
Mouse   132 KHIQHTLVDSQSQEDISLLLQLVQNRDFQNAFKIHNAVTVHMSKASPP---FPLIANVQDLVQEV 193

  Fly    95 IRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLE-IASQR------ 152
            .....|..:.|.:||..||..||.:|||.|||::.   ||.:        ||| |..:|      
Mouse   194 QTVLKPVHQKEGQELTALLNAPHIQALLLAHDKVA---EQEM--------QLEPITDERVYESIG 247

  Fly   153 QTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHV 217
            ..||              ||:|:|.:.:....|||.||. :|...::::||:.||..:|..:||.
Mouse   248 HYGG--------------ETVKIVRIEKARDIPLGATVR-NEMDSVIISRIVKGGAAEKSGLLHE 297

  Fly   218 GDVILEVNGTPVRTPDELQV--EVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLET 280
            ||.:||:||..:|..|..:|  .:|.....||..:.|:  ::||.                  ..
Mouse   298 GDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPS--QQIKP------------------PP 342

  Fly   281 GKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDK--IGLI 343
            .|:...:::|.|.|:||:|..:|||::||.|:.||||.:|:.:|||||||.....|.::  .||:
Mouse   343 AKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLV 407

  Fly   344 PSQELEERRKAF--VAPEADYVHKIG--ICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVT-- 402
            |.:..:::|:|.  ...|.....|.|  .|..:..|:::|.:|.:..|.::|..|:|.|||::  
Mouse   408 PGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLY 472

  Fly   403 RMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEME 467
            ..|..|::.::|||....|:..|:.||:|.:.|:|.:.:|||:|.:|..|..|..|.|:.|:..|
Mouse   473 HQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRNRRDHEVAGRDYHFVSRQAFE 537

  Fly   468 EAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPG 532
            ..:...:|:|:||...|||||.:.|::.|||||::|:|.....:||.|.|| :|.|::||:|.|.
Mouse   538 ADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNS-DLKPYIIFIAPPS 601

  Fly   533 MEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYE 597
            .|:|:.:.|..   |.|.                           :.::|...:|::..:::...
Mouse   602 QERLRALLAKE---GKNP---------------------------KPEELREIIEKTREMEQNNG 636

  Fly   598 KYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWI 635
            .|||..|||.|.|:.:::::..::::..|.||||..|:
Mouse   637 HYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWL 674

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
variNP_724288.3 L27 <105..128 CDD:280918 13/22 (59%)
PDZ_signaling 173..250 CDD:238492 27/78 (35%)
SH3_MPP 287..347 CDD:212796 28/61 (46%)
Guanylate_kin 408..622 CDD:279019 65/213 (31%)
GuKc 418..622 CDD:214504 61/203 (30%)
Pals1NP_062525.1 Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000269|PubMed:17182851 1..345 76/326 (23%)
Interaction with PARD6B. /evidence=ECO:0000269|PubMed:15140881 21..140 16/72 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..79 4/11 (36%)
L27_N 123..170 CDD:370269 6/46 (13%)
Interaction with LIN7C. /evidence=ECO:0000269|PubMed:10753959 181..243 23/72 (32%)
L27 189..237 CDD:197794 19/58 (33%)
PDZ_signaling 254..333 CDD:238492 27/79 (34%)
SH3_MPP5 349..411 CDD:212969 28/61 (46%)
GuKc 491..661 CDD:214504 61/200 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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