DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and pals2

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001017060.1	Gene:	pals2 / 549814	XenbaseID:	XB-GENE-983252	Length:	539	Species:	Xenopus tropicalis

Alignment Length:	607	Identity:	241/607 - (39%)
Similarity:	341/607 - (56%)	Gaps:	92/607 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 STDLSDHDEIFLKGLL-----RSNSNTPHKELMLNPTEPQPVPLFLPAHLNNKPICDDIIRKFSP 100
            ||...:.|.||||||:     ||.:....:   |..|:.:.|      ..||..:.:|||:..||
Frog    14 STGAEEIDIIFLKGLMEDPIVRSLAKAHER---LEDTKLEAV------SENNVELLNDIIKDISP 69

  Fly   101 SRRLES--RELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDV 163
            ....::  :||..:|.:|||::||.|||.:.:      |......|..|:.|   .|.:...
Frog    70 LEHEDTNVQELIGILKEPHFQSLLEAHDVVAS------KCYDSPPSSPEVNS---LGNHQIA--- 122

  Fly   164 LNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTP 228
                 ||:.|:|||:.:...:|||:|.:: |...||:||||.||:||:|.:|||||:|.|:||..
Frog   123 -----PVDAIRMVGIHKRAGEPLGVTFKV-ENNNLVIARILHGGMIDRQGLLHVGDIIKEINGHE 181

  Fly   229 V-RTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALF 292
            | ..|.|||..:.....::||||.|:..:       |||..||                |::..|
Frog   182 VGNNPKELQELLKSISGSVTLKILPSYKD-------TVSPQQV----------------YVKCHF 223

  Fly   293 TYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIPSQELEERRKAFVA 357
            .|||..|:|:||::.||.|..|:||.|:|.:|||||||.:: .|....||||||.|||:|||||
Frog   224 DYNPFSDNLIPCKEAGLKFSKGEILHIVNREDPNWWQASHV-KEGGSAGLIPSQFLEEKRKAFV- 286

  Fly   358 PEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGR 422
             ..|:......|||..||:|:|.||.:..|.|||:.|:.:||||.|||||:||||||||..||||
Frog   287 -RRDWDGSGQFCGTVTSKKKKKMMYLTTRNAEFDRHEIQIYEEVARMPPFQRKTLVLIGAQGVGR 350

  Fly   423 RTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYG 487
            |:||||||..:..:||..:|.|||..|..|::|.:|.|:.|.|||..::...:||:||:.|||||
Frog   351 RSLKNRLIVLNPTQFGTTVPFTSRKPREEEKDGHAYRFVSRTEMEADIKAGRYLEHGEYEGNLYG 415

  Fly   488 THLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIY---ADRRATGSN 549
            |.:.||.:|:.:||.||||..|.|||:|..: |.||:|:|:|||..|.|:.::   .|...|
Frog   416 TKIDSIHEVVMAGRTCILDVNPQALKVLRTA-EFMPYVVFIAAPEFETLRAMHKAVVDAGIT--- 476

  Fly   550 RNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFR 614
                                    ..|..|.||..||:||:.:.|.|..|||:.|||::.|:.|.
Frog   477 ------------------------TKLLTDSDLKKTVDESARITRAYNHYFDVTIVNDNLDKAFE 517

  Fly   615 QVVETLDQMSHEEQWVPVNWIY 636
            ::...:.::..|:||||::|:|
Frog   518 KLQAAVHRLRTEQQWVPISWVY 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	11/24 (46%)
		PDZ_signaling	173..250	CDD:238492	36/77 (47%)
		SH3_MPP	287..347	CDD:212796	30/59 (51%)
		Guanylate_kin	408..622	CDD:279019	88/216 (41%)
		GuKc	418..622	CDD:214504	80/206 (39%)
pals2	NP_001017060.1	L27	2..55	CDD:197794	14/49 (29%)
		L27	57..108	CDD:367207	17/56 (30%)
		PDZ_signaling	127..205	CDD:238492	37/78 (47%)
		SH3_MPP6	218..278	CDD:212971	31/60 (52%)
		Guanylate_kin	336..523	CDD:366206	88/214 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8296
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H22976
Inparanoid	1	1.050	394	1.000	Inparanoid score	I1924
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	1	1.000	-	-		FOG0003013
OrthoInspector	1	1.000	-	-		otm48998
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2005
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060