Protein Alignment vari and pals2

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001017060.1
• Gene: pals2 / 549814
• XenbaseID: XB-GENE-983252
• Length: 539
• Species: Xenopus tropicalis
• Alignment Length: 607
• Identity: 241/607 - (39%)
• Similarity: 341/607 - (56%)
• Gaps: 92/607 - (15%)

  Fly    41 STDLSDHDEIFLKGLL-----RSNSNTPHKELMLNPTEPQPVPLFLPAHLNNKPICDDIIRKFSP 100
            ||...:.|.||||||:     ||.:....:   |..|:.:.|      ..||..:.:|||:..||
 Frog    14 STGAEEIDIIFLKGLMEDPIVRSLAKAHER---LEDTKLEAV------SENNVELLNDIIKDISP 69

  Fly   101 SRRLES--RELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDV 163
            ....::  :||..:|.:|||::||.|||.:.:      |......|..|:.|   .|.:...
 Frog    70 LEHEDTNVQELIGILKEPHFQSLLEAHDVVAS------KCYDSPPSSPEVNS---LGNHQIA--- 122

  Fly   164 LNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTP 228
                 ||:.|:|||:.:...:|||:|.:: |...||:||||.||:||:|.:|||||:|.|:||..
 Frog   123 -----PVDAIRMVGIHKRAGEPLGVTFKV-ENNNLVIARILHGGMIDRQGLLHVGDIIKEINGHE 181

  Fly   229 V-RTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALF 292
            | ..|.|||..:.....::||||.|:..:       |||..||                |::..|
 Frog   182 VGNNPKELQELLKSISGSVTLKILPSYKD-------TVSPQQV----------------YVKCHF 223

  Fly   293 TYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIPSQELEERRKAFVA 357
            .|||..|:|:||::.||.|..|:||.|:|.:|||||||.:: .|....||||||.|||:|||||
 Frog   224 DYNPFSDNLIPCKEAGLKFSKGEILHIVNREDPNWWQASHV-KEGGSAGLIPSQFLEEKRKAFV- 286

  Fly   358 PEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGR 422
             ..|:......|||..||:|:|.||.:..|.|||:.|:.:||||.|||||:||||||||..||||
 Frog   287 -RRDWDGSGQFCGTVTSKKKKKMMYLTTRNAEFDRHEIQIYEEVARMPPFQRKTLVLIGAQGVGR 350

  Fly   423 RTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYG 487
            |:||||||..:..:||..:|.|||..|..|::|.:|.|:.|.|||..::...:||:||:.|||||
 Frog   351 RSLKNRLIVLNPTQFGTTVPFTSRKPREEEKDGHAYRFVSRTEMEADIKAGRYLEHGEYEGNLYG 415

  Fly   488 THLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIY---ADRRATGSN 549
            |.:.||.:|:.:||.||||..|.|||:|..: |.||:|:|:|||..|.|:.::   .|...|
 Frog   416 TKIDSIHEVVMAGRTCILDVNPQALKVLRTA-EFMPYVVFIAAPEFETLRAMHKAVVDAGIT--- 476

  Fly   550 RNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFR 614
                                    ..|..|.||..||:||:.:.|.|..|||:.|||::.|:.|.
 Frog   477 ------------------------TKLLTDSDLKKTVDESARITRAYNHYFDVTIVNDNLDKAFE 517

  Fly   615 QVVETLDQMSHEEQWVPVNWIY 636
            ::...:.::..|:||||::|:|
 Frog   518 KLQAAVHRLRTEQQWVPISWVY 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	11/24 (46%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	37/78 (47%)
		SH3_MPP	287..347	CDD:212796	30/59 (51%)
		Guanylate_kin	408..622	CDD:395500	88/216 (41%)
pals2	NP_001017060.1	L27	2..55	CDD:197794	14/49 (29%)
		L27	57..108	CDD:460717	17/56 (30%)
		PDZ_MPP6-MPP2-like	128..206	CDD:467268	37/78 (47%)
		SH3_MPP6	218..278	CDD:212971	31/60 (52%)
		Guanylate_kin	336..523	CDD:395500	88/214 (41%)