DRSC/TRiP Functional Genomics Resources

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Protein Alignment vari and cask

DIOPT Version :9

Sequence 1:NP_724288.3 Gene:vari / 35343 FlyBaseID:FBgn0250785 Length:636 Species:Drosophila melanogaster
Sequence 2:XP_012812392.1 Gene:cask / 548958 XenbaseID:XB-GENE-1014725 Length:926 Species:Xenopus tropicalis


Alignment Length:628 Identity:212/628 - (33%)
Similarity:332/628 - (52%) Gaps:95/628 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 TDLSDHDEIFLKGLLRSNSNTPHKELMLN-----PTEPQPVPLFLPAHLNNKPI-----CDDIIR 96
            ||.|:.|..||..:.:..    |...:|:     .|:..|       .:.|.|.     ..:::.
 Frog   361 TDCSEKDLDFLHSVFQDQ----HLHTLLDLYDKINTKSSP-------QIRNPPSDAVQRAKEVLE 414

  Fly    97 KFS--PSRRLESRELAKLLAQPHFRALLRAHDEIG-ALY-EQRLKAAGGSTS-QLEIASQRQTGG 156
            :.|  |... :::||.::|.||||.|||:.||.:. .:| ::.|:.....|| .|...|.....|
 Frog   415 EISCYPENN-DAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANG 478

  Fly   157 YLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVI 221
            .:..|:|..       :::|..:::..:|:|:|::::|....:||||:.||:|.:|..|||||.|
 Frog   479 DMDMENVTR-------VRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEI 536

  Fly   222 LEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNV---------DEEIKSGRYTVSGGQVKQNGI 275
            .|:||..|  :|.::||..:...:.::|.||.|:.         |....|.:...:|.....|.:
 Frog   537 REINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSINNSV 601

  Fly   276 ASLET-----GKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITA 335
            :.:.|     |:::  |:||.|.|:|::|.|:||::.|:.|:.|||:|||:..|.||||.|...|
 Frog   602 SDIPTTTQTKGRQI--YVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENA 664

  Fly   336 ESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKR--KTMYRSVANCEFDKAELLLY 398
            ::...|||||.||:|.|.|.:|.|.....:...| |...|:|:  |..|.:..|..||:.:|:.|
 Frog   665 KNGTAGLIPSPELQEWRVACIAMEKTKQEQQASC-TWFGKKKKQYKDKYLAKHNAVFDQLDLVTY 728

  Fly   399 EEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDR 463
            |||.::|.|:||||||:|..|||||.:||.||....|:|...||||:||.:..||||.:|:|:..
 Frog   729 EEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYFFVSH 793

  Fly   464 EEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFV 528
            ::|.:.:.|||:||||.|...:|||.|::|:.:...|.:.|||..|.|||:|..: |..|||:|:
 Frog   794 DQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTA-EFAPFVVFI 857

  Fly   529 AAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQ 593
            |||      ||                                 ..|:.||:.|....:||..:|
 Frog   858 AAP------TI---------------------------------TPSISEDESLQRLQKESEILQ 883

  Fly   594 RKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            |.|..|||:.|:|.:.|||.|.:.:.::.:....|||||:|:|
 Frog   884 RTYAHYFDLTIINNEIDETIRHLEDAIELVCTAPQWVPVSWVY 926

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
variNP_724288.3 L27 <105..128 CDD:280918 12/22 (55%)
PDZ_signaling 173..250 CDD:238492 27/78 (35%)
SH3_MPP 287..347 CDD:212796 30/59 (51%)
Guanylate_kin 408..622 CDD:279019 81/213 (38%)
GuKc 418..622 CDD:214504 74/203 (36%)
caskXP_012812392.1 STKc_CASK 8..307 CDD:270996
L27 348..401 CDD:197794 10/50 (20%)
L27 406..456 CDD:367207 15/50 (30%)
PDZ_signaling 488..568 CDD:238492 28/79 (35%)
SH3_MPP1-like 616..677 CDD:212968 30/60 (50%)
Guanylate_kin 738..911 CDD:366206 81/212 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D364535at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.010

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