DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and Dlg3

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_006528186.1	Gene:	Dlg3 / 53310	MGIID:	1888986	Length:	867	Species:	Mus musculus

Alignment Length:	656	Identity:	175/656 - (26%)
Similarity:	287/656 - (43%)	Gaps:	131/656 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NGEDDTSDNAAFRNSTDLSD--HDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPLFLPAHLNNKP 89
            :|.....|.....|:|:|.|  |:|     .:.|..||... :.|...:|..:      |||:..
Mouse   287 DGRLQIGDRLLAVNNTNLQDVRHEE-----AVASLKNTSDM-VYLKVAKPGSI------HLNDMY 339

  Fly    90 ICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQT 154
            ...|....|:            .||..|    :..:..:|.|.....|....:..|:........
Mouse   340 APPDYASTFT------------ALADNH----ISHNSSLGYLGAVESKVTYPAPPQVPPTRYSPI 388

  Fly   155 GGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLT-VELDEFKQLVVARILAGGVIDKQSMLHVG 218
            ..::..|:.. |:.|.:.|...|     |..||.. |..::.:.:.|:.|||||..|....|..|
Mouse   389 PRHMLAEEDF-TREPRKIILHKG-----STGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRG 447

  Fly   219 DVILEVNGTPVR--TPDELQVEVSRAKENLTLKIGPNVDE------EIKSGRYTVSGGQVKQNGI 275
            |.||.|||..:|  |.::....:.||.:::|:......:|      :|...|..:....: .:|.
Mouse   448 DRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSM-SSGS 511

  Fly   276 ASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNIT--AESD 338
            .||.|.:|.:.|:||||.|:.:.||.||.:  ||.|..||||.:||..|..||||:.:|  .||:
Mouse   512 GSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--GLSFSYGDILHVINASDDEWWQARLVTPHGESE 574

  Fly   339 KIGLIPSQELEERRKAFVAPEADYVHKIG-ICGTRISKRKRKTMYRSVANCEFDKAE-------- 394
            :||:|||::..|:::........:..:.| |...|..|.|||..:|......|.|::
Mouse   575 QIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQENS 639

  Fly   395 -----------------------LLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDV-- 434
                                   :|.||.|||......:.::::|       .:|:| :|.|:
Mouse   640 IQEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILG-------PMKDR-VNDDLIS 696

  Fly   435 ---DKFGAVIPHTSRPKRALEENGSSYWF-MDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKD 495
               .|||:.:|||:||:|..|.:|..|.| :.||:||:.:::|:|:|.|:.|.|||||.:||::.
Mouse   697 EFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRA 761

  Fly   496 VINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSI 560
            |...|:.||||.:.||:|.|..:| |.|..||:....:|.|..:  :||.|....|..||:...:
Mouse   762 VAERGKHCILDVSGNAIKRLQQAQ-LYPIAIFIKPKSIEALMEM--NRRQTYEQANKIFDKAMKL 823

  Fly   561 RFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSH 625
                                            ::::.:||..::..:..:|.:.::.:.::..|.
Mouse   824 --------------------------------EQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSG 856

  Fly   626 EEQWVP 631
            ...|||
Mouse   857 HYIWVP 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	3/22 (14%)
		PDZ_signaling	173..250	CDD:238492	26/79 (33%)
		SH3_MPP	287..347	CDD:212796	32/61 (52%)
		Guanylate_kin	408..622	CDD:279019	60/219 (27%)
		GuKc	418..622	CDD:214504	59/209 (28%)
Dlg3	XP_006528186.1	MAGUK_N_PEST	52..148	CDD:371162
		PDZ_signaling	149..226	CDD:238492
		PDZ_signaling	242..328	CDD:238492	12/46 (26%)
		PDZ_assoc	329..403	CDD:371157	15/96 (16%)
		PDZ_signaling	402..480	CDD:238492	27/82 (33%)
		SH3_DLG3	520..586	CDD:212962	32/67 (48%)
		Guanylate_kin	676..854	CDD:366206	60/220 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810