Protein Alignment vari and PALS2

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_057531.2
• Gene: PALS2 / 51678
• HGNCID: 18167
• Length: 540
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 235/615 - (38%)
• Similarity: 341/615 - (55%)
• Gaps: 105/615 - (17%)

  Fly    40 NSTDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPLFLPAHL------------NNKPICD 92
            :||...:.|.|||||            :|.||.    |.....||.            ||..:.:
Human    13 SSTGAEEIDLIFLKG------------IMENPI----VKSLAKAHERLEDSKLEAVSDNNLELVN 61

  Fly    93 DIIRKFSPSRRLESR--ELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTG 155
            :|:...:|...::..  ||..:|.:|||::||.|||.:.:      |......|..|:.:
Human    62 EILEDITPLINVDENVAELVGILKEPHFQSLLEAHDIVAS------KCYDSPPSSPEMNN----- 115

  Fly   156 GYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDV 220
                 ..:.|..:||:.|:::|:.:...:|||:|..: |...||:||||.||:||:|.:|||||:
Human   116 -----SSINNQLLPVDAIRILGIHKRAGEPLGVTFRV-ENNDLVIARILHGGMIDRQGLLHVGDI 174

  Fly   221 ILEVNGTPV-RTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKL 284
            |.||||..| ..|.|||..:.....::||||.|       |.|.|::..||
Human   175 IKEVNGHEVGNNPKELQELLKNISGSVTLKILP-------SYRDTITPQQV-------------- 218

  Fly   285 TCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIPSQELE 349
              :::..|.|||..|:|:||::.||.|..|:||||:|.:|||||||.:: .|....||||||.||
Human   219 --FVKCHFDYNPYNDNLIPCKEAGLKFSKGEILQIVNREDPNWWQASHV-KEGGSAGLIPSQFLE 280

  Fly   350 ERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRRKTLVL 414
            |:|||||  ..|:.:....|||..||:|:|.||.:..|.|||:.|:.:||||.:||||:||||||
Human   281 EKRKAFV--RRDWDNSGPFCGTISSKKKKKMMYLTTRNAEFDRHEIQIYEEVAKMPPFQRKTLVL 343

  Fly   415 IGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYG 479
            ||..|||||:||||.|..:..:||..:|.|||..|..|::|.:|.|:.|.|||..::..::||:|
Human   344 IGAQGVGRRSLKNRFIVLNPTRFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGKYLEHG 408

  Fly   480 EHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIY---A 541
            |:.||||||.:.||.:|:.:||.||||..|.|||:|..| |.||:|:|:|||.:|.|:.::   .
Human   409 EYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTS-EFMPYVVFIAAPELETLRAMHKAVV 472

  Fly   542 DRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVN 606
            |...|                           ..|..|.||..||:||:.:||.|..|||::|:|
Human   473 DAGIT---------------------------TKLLTDSDLKKTVDESARIQRAYNHYFDLIIIN 510

  Fly   607 EDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            ::.|:.|.::...::::..|.||||::|:|
Human   511 DNLDKAFEKLQTAIEKLRMEPQWVPISWVY 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	11/24 (46%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	36/78 (46%)
		SH3_MPP	287..347	CDD:212796	30/59 (51%)
		Guanylate_kin	408..622	CDD:395500	88/216 (41%)
PALS2	NP_057531.2	L27	2..55	CDD:197794	14/57 (25%)
		L27	57..108	CDD:460717	14/56 (25%)
		PDZ_MPP6-MPP2-like	129..207	CDD:467268	36/78 (46%)
		SH3_MPP6	219..279	CDD:212971	31/60 (52%)
		Guanylate_kin	337..527	CDD:395500	88/217 (41%)