Protein Alignment vari and Mpp2

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001343253.1
• Gene: Mpp2 / 50997
• MGIID: 1858257
• Length: 569
• Species: Mus musculus
• Alignment Length: 642
• Identity: 238/642 - (37%)
• Similarity: 349/642 - (54%)
• Gaps: 105/642 - (16%)

  Fly     6 ARSRRQARQDKVELLARNNKVNGEDDTSDNAAFRNSTDLSDHDEIFLKGLLRS----NSNTPHKE 66
            |..||:|.|..::.|               .:..|:|..::.|.|||:|::.|    :....|:.
Mouse    22 AELRREAMQQVLDNL---------------GSLPNATGAAELDLIFLRGIMESPIVRSLAKAHER 71

  Fly    67 LMLNPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLES--RELAKLLAQPHFRALLRAHDEIG 129
              |..|:.:.|      ..||..:..:|:|..:......|  .|||::|.:|||::||..||.:.
Mouse    72 --LEETKLEAV------RDNNLELVQEILRDLAELAEQSSTAAELARILQEPHFQSLLETHDSVA 128

  Fly   130 A-LYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELD 193
            : .||....:.|                  ......|..:|.:.::|||:|:...:.||:|..:
Mouse   129 SKTYETPPPSPG------------------LDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRV- 174

  Fly   194 EFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRT-PDELQVEVSRAKENLTLKIGPNVDEE 257
            |..:||:||||.||::.:|.:|||||:|.||||.||.: |..||..:..|..::.|||.|:..|
Mouse   175 EGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPVGSDPRALQELLRSASGSVILKILPSYQE- 238

  Fly   258 IKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINV 322
                              ..|.....:.|:    |.|:|:.|||.||::.||.|.:||:|||:|.
Mouse   239 ------------------PHLPRQVFVKCH----FDYDPARDSLSPCKEAGLRFNAGDLLQIVNQ 281

  Fly   323 KDPNWWQAKNITAESDKIGLIPSQELEERRKAFVAPEADYVHKIG-ICGTRISKRKRKTMYRSVA 386
            .|.|||||.::  |....||||||.|||:|||||..:.:.....| :||:...|:|::.||.:..
Mouse   282 DDANWWQACHV--EGGSAGLIPSQLLEEKRKAFVKRDLELTPTSGTLCGSLSGKKKKRMMYLTTK 344

  Fly   387 NCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRAL 451
            |.|||:.|||:||||.||||||||||||||..|||||:|||:||..|.|::|..:|:|||..:..
Mouse   345 NAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLILWDPDRYGTTVPYTSRRPKDS 409

  Fly   452 EENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILH 516
            |..|..|.|:.|.|||..:|...:||:||:.||||||.:.||:.|:.||::|:||..|.|:|:|.
Mouse   410 EREGQGYSFVSRGEMEADIRAGRYLEHGEYEGNLYGTRIDSIRGVVASGKVCVLDVNPQAVKVLR 474

  Fly   517 NSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYE--D 579
            .: |.:|:|:|:.||..|.|:.:         ||                 ..|||..|..:  :
Mouse   475 TA-EFVPYVVFIEAPDYETLRAM---------NR-----------------AALESGVSTKQLTE 512

  Fly   580 DDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            .||..||||||.:||.|..|||:.:||.:.:.|||::...::::..|.|||||:|:|
Mouse   513 ADLRRTVEESSRIQRGYGHYFDLSLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	12/24 (50%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	36/78 (46%)
		SH3_MPP	287..347	CDD:212796	29/59 (49%)
		Guanylate_kin	408..622	CDD:395500	90/215 (42%)
Mpp2	NP_001343253.1	L27	30..83	CDD:197794	14/75 (19%)
		L27	85..136	CDD:460717	16/50 (32%)
		PDZ_MPP6-MPP2-like	156..234	CDD:467268	36/78 (46%)
		SH3_MPP2	246..304	CDD:212970	30/63 (48%)
		GuKc	376..557	CDD:214504	81/207 (39%)