Protein Alignment vari and mpp1

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001008152.1
• Gene: mpp1 / 493514
• XenbaseID: XB-GENE-5787649
• Length: 460
• Species: Xenopus tropicalis
• Alignment Length: 554
• Identity: 185/554 - (33%)
• Similarity: 274/554 - (49%)
• Gaps: 110/554 - (19%)

  Fly    89 PICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQ 153
            |:||             |..:...|:..:...||          :.|..|.|..||......:..
 Frog    11 PLCD-------------SSSVRTALSDLYLETLL----------QNRGSAKGYQTSVGSHTEEIY 52

  Fly   154 TGGYLF--TEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLH 216
            |.|...  ||:       .:.:::|...|:..:|:|:|::::..:..:|||||.||.|.:|..||
 Frog    53 TNGSAASGTEE-------KKRVRLVQFERETEEPMGITLKVNSQQSCIVARILHGGFIHRQGSLH 110

  Fly   217 VGDVILEVNGTPVR--TPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLE 279
            |||.|||:||..||  :.|.||..:..:|..:.||:.|:                         :
 Frog   111 VGDEILEINGKSVRNQSVDHLQSVLKESKGTVVLKVSPS-------------------------Q 150

  Fly   280 TGKK--LTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGL 342
            :.:|  |..|:||||.|||..|:|:|||:.||.|.:||||||||..|.||||.: :..|. ..||
 Frog   151 SNRKPPLQMYVRALFDYNPLSDTLIPCREAGLAFHTGDILQIINKDDSNWWQGR-LQGEG-SAGL 213

  Fly   343 IPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPPF 407
            |||.||:|.|   ||..:........|.....|:|.|..|.:..:..||:.:::.||||..:|.|
 Frog   214 IPSPELQEWR---VASSSTTNQNPQSCSPFSKKKKCKDKYLAKHSSIFDQLDVVSYEEVVSLPAF 275

  Fly   408 RRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRN 472
            .||||||||||||||..:||.|:....::|....||||||.:..||...||.|:..|||..|:..
 Frog   276 TRKTLVLIGVSGVGRSHIKNTLLAKYPERFVYPAPHTSRPPKRGEEESGSYHFVSAEEMSRAISE 340

  Fly   473 NEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLK 537
            |||||||..:|.::||.:|::|:|...|::.|||..|..||::..: ||.||::|::..
 Frog   341 NEFLEYGSFSGYMFGTKIQTVKEVHKDGKVAILDIEPQTLKMVRTA-ELAPFIVFISPT------ 398

  Fly   538 TIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDM 602
                             |::.|           |:|..|..|.|:         ::.:|.::||:
 Frog   399 -----------------DKEES-----------EALQKLRADSDV---------LRSRYAQHFDL 426

  Fly   603 VIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            .:||...::|.:.::|..|......|||||.|:|
 Frog   427 TLVNNGVEQTVQDLLEAFDAACSSPQWVPVTWVY 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	4/22 (18%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	32/79 (41%)
		SH3_MPP	287..347	CDD:212796	35/59 (59%)
		Guanylate_kin	408..622	CDD:395500	72/213 (34%)
mpp1	NP_001008152.1	PDZ_MPP1-like	68..148	CDD:467266	32/79 (41%)
		SH3	160..219	CDD:473055	35/60 (58%)
		Guanylate_kin	277..447	CDD:395500	73/213 (34%)