Protein Alignment vari and CASK

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_061499758.1
• Gene: CASK / 4577273
• VectorBaseID: AGAMI1_013356
• Length: 955
• Species: Anopheles gambiae
• Alignment Length: 689
• Identity: 220/689 - (31%)
• Similarity: 327/689 - (47%)
• Gaps: 144/689 - (20%)

  Fly    12 ARQDKVELLARNNKVN-GEDDTSDNAAFRNSTDLSDH---------DEIFLKGLLRSNSNTPHKE 66
            |..|.:.:.|.:..:| ..|:.:...|.:...|..|.         |...|.|:||   :....|
Mosquito   347 ADTDSMAIGAASESLNEWADEEAGLEAIQKILDSLDDIIALQDANCDPDMLAGMLR---DVKLHE 408

  Fly    67 LM----------LNPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRR----LESRELAKLLAQPH 117
            |:          :||:...|....        ..|.|.|...|.:..    .|..||..||..||
Mosquito   409 LLQLFDRISSSVINPSRAPPGDAI--------SRCRDAIDVISSTAGHKYVREKSELINLLGSPH 465

  Fly   118 FRALLRAHDEIG-ALY-EQRLKAA--------GGSTSQLEIASQRQTGGYLFTEDVLNTKMPVET 172
            .:|||..||.:. .:| |:.|:..        .|...:|:    ....|.|         ..|..
Mosquito   466 IQALLHTHDVVAREVYGEEALRVTPPPIAPYLNGGNDELD----NGDAGEL---------QHVTR 517

  Fly   173 IKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPV--RTPDEL 235
            :::|..:::..:|:|:|:::.|..:.:||||:.||:|.:|:.|||||.|.|:||.||  :|..:|
Mosquito   518 VRLVQFQKNTDEPMGITLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQTVSQL 582

  Fly   236 QVEVSRAKENLTLKIGP---NVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPS 297
            |..:..|:.::|.||.|   :....::..|...:...|.|             .::||.|.|:|.
Mosquito   583 QRLLRDARGSVTFKIVPSYRSAPPPVELFRIRPAPVLVDQ-------------IFVRAQFDYDPL 634

  Fly   298 EDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIPSQELEERRKAFVAPEADY 362
            :|.|:||...|:.|:.|||||||:..|.:||||:: .|.....|||||.||:|.|.|  ...||.
Mosquito   635 DDELIPCAQAGIAFRVGDILQIISKDDHHWWQARH-DAAGGSAGLIPSPELQEWRIA--CQSADK 696

  Fly   363 VHK----IG--------------ICGTRISKRKRK---TMYRSVANCEFDKAELLLYEEVTRM-- 404
            .||    .|              :....|..||:|   ..|.:..|..||:.:|:.||||.::
Mosquito   697 SHKEQGEAGPGCSAQAEGCEGPTVVNCSIFSRKKKQCRDKYLAKHNAVFDQLDLVTYEEVVKVPI 761

  Fly   405 --PPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEME 467
              |.|:|:||||:|..|||||.:||.||....||:...||||:||.|..||||.||:|:..:||.
Mosquito   762 GDPAFQRRTLVLLGAHGVGRRHIKNTLIAKYPDKYAYPIPHTTRPPRPDEENGRSYYFISHDEMM 826

  Fly   468 EAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPG 532
            ..:..||:||||.|...:|||.|::|:.:...|:|.|||..|.|||||..: |..|:|:|:|||.
Mosquito   827 ADISANEYLEYGTHEDAMYGTKLETIRRIHADGKMAILDVEPQALKILRTA-EFTPYVVFIAAPL 890

  Fly   533 MEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYE 597
            ::.:    ||           :|            .:||.||            :||..:::.|.
Mosquito   891 LQNI----AD-----------YD------------GSLERLA------------KESDMLRQAYG 916

  Fly   598 KYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            .:||:.|||.|..||...:...:|::....|||||:|:|
Mosquito   917 HFFDLTIVNNDIGETIATLENAIDKVHSTAQWVPVSWLY 955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	12/22 (55%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	31/79 (39%)
		SH3_MPP	287..347	CDD:212796	29/59 (49%)
		Guanylate_kin	408..622	CDD:395500	81/213 (38%)
CASK	XP_061499758.1	None