DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and sdt

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster

Alignment Length:	650	Identity:	181/650 - (27%)
Similarity:	293/650 - (45%)	Gaps:	147/650 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 PAHLNNKPICDDIIRKFSPSRRLESRELAKLLAQPHFRALLRAHDEIGALYE----------QRL 136
            |.|.::..:..||:...:.|....:.||..||.......||.|||.|....:          ..:
  Fly  1417 PLHHSSLGLQKDIVELLTQSNTAAAIELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAI 1481

  Fly   137 KAAGGSTSQLEIASQRQTGGYLFTEDV-----------------------------LNTKMPV-- 170
            .||.|||....:|..::..|.:....|                             :...|||
  Fly  1482 GAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVNL 1546

  Fly   171 -------------ETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVIL 222
                         :.|:::.:.:. ::|||.||. :|.:.:|:.||:.||..:|..:||.||.||
  Fly  1547 PMSACFGTLNDQNDNIRIIQIEKS-TEPLGATVR-NEGEAVVIGRIVRGGAAEKSGLLHEGDEIL 1609

  Fly   223 EVNGTPVR--TPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKL- 284
            ||||..:|  |.:|:...:...:..||..|.|              .|.....|:....||.:|
  Fly  1610 EVNGQELRGKTVNEVCALLGAMQGTLTFLIVP--------------AGSPPSVGVMGGTTGSQLA 1660

  Fly   285 ----------TCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDK 339
                      ..::||.|.|:|.:|..:|||::|:.|:.||:|.:|:.:|||||||.....|...
  Fly  1661 GLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYREGEEDQT 1725

  Fly   340 I-GLIPSQELEERR---KAFVAPEADYVHKIG-----------ICGTRISKRKRKT-------MY 382
            : ||||||..:.:|   |..:|.||......|           :|..:..|:|:|.       :|
  Fly  1726 LAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDGSGSKGATLLCARKGRKKKKKASSEAGYPLY 1790

  Fly   383 RSVANCEFDKAELLLYEEVTRMPP--FRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTS 445
            .:.|..|.|..|:|.||||....|  ..::.:||||...:||..|:.||: :|.::|.|.:||||
  Fly  1791 ATTAPDETDPEEILTYEEVALYYPRATHKRPIVLIGPPNIGRHELRQRLM-ADSERFSAAVPHTS 1854

  Fly   446 RPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPN 510
            |.:|..|..|..|.|:.|:..|..:....|:|:||:....|||.|::|:.|:.||::|:|:..|.
  Fly  1855 RARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQ 1919

  Fly   511 ALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIR----FSSRRARTLE 571
            :||:|..| :|.|:|:.||.|.:::|                   ||..:|    |.....:
  Fly  1920 SLKLLRAS-DLKPYVVLVAPPSLDKL-------------------RQKKLRNGEPFKEEELK--- 1961

  Fly   572 SLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
                     |::||..:   ::.::...|||:|:|.|.:..:.|::..::.:..|.||||..|::
  Fly  1962 ---------DIIATARD---MEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWVH 2014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	9/22 (41%)
		PDZ_signaling	173..250	CDD:238492	28/78 (36%)
		SH3_MPP	287..347	CDD:212796	28/60 (47%)
		Guanylate_kin	408..622	CDD:279019	64/217 (29%)
		GuKc	418..622	CDD:214504	60/207 (29%)
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	13/42 (31%)
		PDZ_signaling	1562..1640	CDD:238492	28/79 (35%)
		SH3_MPP5	1673..1734	CDD:212969	28/60 (47%)
		Guanylate_kin	1820..1994	CDD:279019	63/209 (30%)
		GuKc	1831..2002	CDD:214504	60/206 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468178
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23122
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840