Protein Alignment vari and MPP3

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001317162.1
• Gene: MPP3 / 4356
• HGNCID: 7221
• Length: 610
• Species: Homo sapiens
• Alignment Length: 684
• Identity: 200/684 - (29%)
• Similarity: 311/684 - (45%)
• Gaps: 168/684 - (24%)

  Fly    29 EDDTSDNAAFR-NSTDLSDHDEI-FLKGLLRSNSNTPHKELM---------------------LN 70
            |....|||:.. .|.|...|:.: .|...||.:||  |||.|                     |.
Human    17 ERSGGDNASMPVLSEDSGLHETLALLTSQLRPDSN--HKEEMGFLRDVFSEKSLSYLMKIHEKLR 79

  Fly    71 PTEPQ-PVPLFLPAHLNNKPICDDIIRKF-SPSRRLESRELAKLLAQPHFRALLRAHDEIGALYE 133
            ..|.| |.|:...|    ..:.:|::.:. :.|...:.|||.:||:.||.||:|..||.:
Human    80 YYERQSPTPVLHSA----VALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTV----- 135

  Fly   134 QRLKAAGGSTSQLEIASQRQTGGYL-FTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFK- 196
                            :|:.....| ...|.::.....|::|:|.|.:: .:|||.|:..||..
Human   136 ----------------AQKNFDPVLPPLPDNIDEDFDEESVKIVRLVKN-KEPLGATIRRDEHSG 183

  Fly   197 QLVVARILAGGVIDKQSMLHVGDVILEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNVDEEIK 259
            .:|||||:.||..|:..::||||.:.||||..|  :.|||:...:::::.::||||.|...||
Human   184 AVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPATQEE-- 246

  Fly   260 SGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKD 324
                    .::|::.:           :|||||.|||.||..:||::.||||:...:|::::..|
Human   247 --------DRLKESKV-----------FMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDD 292

  Fly   325 PNWWQAKNITAESDKIGLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRK-RKTMY-----R 383
            |.|||||.:...:.:.|||||:..:|||.::..          ..||..|.:. ||..|     :
Human   293 PTWWQAKRVGDTNLRAGLIPSKGFQERRLSYRR----------AAGTLPSPQSLRKPPYDQPCDK 347

  Fly   384 SVANCE----------------------------------FDKAELLLYEEVTR---MPPFRRKT 411
            ...:||                                  .:..|||.||||.|   .|..|.:.
Human   348 ETCDCEGYLKGHYVAGLRRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRL 412

  Fly   412 LVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFL 476
            :||||..|.....||.:::..:...||..:|||:||:::.|:.|..|.|:.::..|..:.:|:||
Human   413 VVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNKFL 477

  Fly   477 EYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKT--- 538
            |:||:..|||||.|::|:.|:...::|::|..|.|||.|..| |..|::|||.....|:.||
Human   478 EHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTS-EFKPYIIFVKPAIQEKRKTPPM 541

  Fly   539 --IYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFD 601
              ...|..|       .||.|..           |..||             ::|:.|.|....|
Human   542 SPACEDTAA-------PFDEQQQ-----------EMAAS-------------AAFIDRHYGHLVD 575

  Fly   602 MVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWI 635
            .|:|.||....:.|:...|:::|.:..||||:|:
Human   576 AVLVKEDLQGAYSQLKVVLEKLSKDTHWVPVSWV 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	12/22 (55%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	33/80 (41%)
		SH3_MPP	287..347	CDD:212796	29/59 (49%)
		Guanylate_kin	408..622	CDD:395500	68/218 (31%)
MPP3	NP_001317162.1	L27	37..89	CDD:197794	13/53 (25%)
		L27	94..144	CDD:460717	15/70 (21%)
		PDZ_MPP3-MPP4-MPP7-like	161..241	CDD:467260	33/80 (41%)
		SH3_MPP3	255..316	CDD:212972	29/60 (48%)
		GuKc	420..596	CDD:214504	63/207 (30%)