Protein Alignment vari and MPP2

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_011523129.2
• Gene: MPP2 / 4355
• HGNCID: 7220
• Length: 630
• Species: Homo sapiens
• Alignment Length: 651
• Identity: 237/651 - (36%)
• Similarity: 347/651 - (53%)
• Gaps: 111/651 - (17%)

  Fly    20 LARNNKVNGEDDTSDN-AAFRNSTDLSDHDEIFLKGLLRS------------------NSNTPHK 65
            :|..|.........|| .:..::|..::.|.|||:|::.|                  |...|.|
Human    57 VAATNSETAMQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRSLAKVIMVLWFMQQNVFVPMK 121

  Fly    66 ELM--------LNPTEPQPVPLFLPAHLNNKPICDDIIRKFSPSRRLES--RELAKLLAQPHFRA 120
            .::        |..|:.:.|      ..||..:..:|:|..:......|  .|||.:|.:|||::
Human   122 YMLKYFGAHERLEETKLEAV------RDNNLELVQEILRDLAQLAEQSSTAAELAHILQEPHFQS 180

  Fly   121 LLRAHDEIGA-LYEQRLKAAGGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSK 184
            ||..||.:.: .||....:.|                  ......|..:|.:.::|||:|:...:
Human   181 LLETHDSVASKTYETPPPSPG------------------LDPTFSNQPVPPDAVRMVGIRKTAGE 227

  Fly   185 PLGLTVELDEFKQLVVARILAGGVIDKQSMLHVGDVILEVNGTPVRT-PDELQVEVSRAKENLTL 248
            .||:|..: |..:||:||||.||::.:|.:|||||:|.||||.||.: |..||..:..|..::.|
Human   228 HLGVTFRV-EGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPVGSDPRALQELLRNASGSVIL 291

  Fly   249 KIGPNVDEEIKSGRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKS 313
            ||.|:..|                   ..|.....:.|:    |.|:|:.|||:||::.||.|.:
Human   292 KILPSYQE-------------------PHLPRQVFVKCH----FDYDPARDSLIPCKEAGLRFNA 333

  Fly   314 GDILQIINVKDPNWWQAKNITAESDKIGLIPSQELEERRKAFVAPEADYVHKIG-ICGTRISKRK 377
            ||:|||:|..|.|||||.::  |....||||||.|||:|||||..:.:.....| :||:...|:|
Human   334 GDLLQIVNQDDANWWQACHV--EGGSAGLIPSQLLEEKRKAFVKRDLELTPNSGTLCGSLSGKKK 396

  Fly   378 RKTMYRSVANCEFDKAELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIP 442
            ::.||.:..|.|||:.|||:||||.||||||||||||||..|||||:|||:||..|.|::|..:|
Human   397 KRMMYLTTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVP 461

  Fly   443 HTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDC 507
            :|||..:..|..|..|.|:.|.|||..||...:||:||:.||||||.:.||:.|:.:|::|:||.
Human   462 YTSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDV 526

  Fly   508 APNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLES 572
            .|.|:|:|..: |.:|:|:|:.||..|.|:.:         ||                 ..|||
Human   527 NPQAVKVLRTA-EFVPYVVFIEAPDFETLRAM---------NR-----------------AALES 564

  Fly   573 LASLYE--DDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWI 635
            ..|..:  :.||..||||||.:||.|..|||:.:||.:.:.|||::...::::..|.|||||:|:
Human   565 GISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPVSWV 629

  Fly   636 Y 636
            |
Human   630 Y 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	12/24 (50%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	36/78 (46%)
		SH3_MPP	287..347	CDD:212796	29/59 (49%)
		Guanylate_kin	408..622	CDD:395500	90/215 (42%)
MPP2	XP_011523129.2	L27	67..144	CDD:197794	15/82 (18%)
		L27	146..197	CDD:460717	16/50 (32%)
		PDZ_MPP6-MPP2-like	217..295	CDD:467268	36/78 (46%)
		SH3_MPP2	307..365	CDD:212970	30/63 (48%)
		GuKc	437..618	CDD:214504	81/207 (39%)