Protein Alignment vari and MPP1

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_002427.1
• Gene: MPP1 / 4354
• HGNCID: 7219
• Length: 466
• Species: Homo sapiens
• Alignment Length: 491
• Identity: 172/491 - (35%)
• Similarity: 263/491 - (53%)
• Gaps: 82/491 - (16%)

  Fly   160 TEDVLNTKMP------------VETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQ 212
            |||:.....|            |..::::...:...:|:|:|::|:|.:...|||||.||:|.:|
Human    44 TEDMYTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQ 108

  Fly   213 SMLHVGDVILEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGI 275
            ..|||||.|||:|||.|  .:.|:||..:...|..::||:.||                 :|:.:
Human   109 GSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPN-----------------QQSRL 156

  Fly   276 ASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKI 340
            .:|:      .:|||.|.|:|.:|:|:||::.||.|.:|||:||||..|.||||.:...:..:..
Human   157 PALQ------MFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESA 215

  Fly   341 GLIPSQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMP 405
            |||||.||:|.|.|.:|..|.  .:...|.....|:|.|..|.:..:..||:.:::.||||.|:|
Human   216 GLIPSPELQEWRVASMAQSAP--SEAPSCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLP 278

  Fly   406 PFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAV 470
            .|:||||||||.|||||..:||.|::.:.:||...:|:|:||.|..||:|..|.|:..|||...:
Human   279 AFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNI 343

  Fly   471 RNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQ 535
            ..|||||:|.:.||::||..:::..:....::.|||..|..|||:..: ||.||::|: ||..:.
Human   344 SANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTA-ELSPFIVFI-APTDQG 406

  Fly   536 LKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYF 600
            .:|                                |:|..|.:|         |..::.:|..||
Human   407 TQT--------------------------------EALQQLQKD---------SEAIRSQYAHYF 430

  Fly   601 DMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            |:.:||...|||.:::.|..||.....|||||:|:|
Human   431 DLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWVY 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	32/79 (41%)
		SH3_MPP	287..347	CDD:212796	30/59 (51%)
		Guanylate_kin	408..622	CDD:395500	71/213 (33%)
MPP1	NP_002427.1	PDZ_MPP1-like	70..150	CDD:467266	32/79 (41%)
		SH3_MPP1	162..223	CDD:213013	30/60 (50%)
		Interaction with PALS1. /evidence=ECO:0000269|PubMed:17584769	268..466		86/240 (36%)
		Guanylate_kin	281..453	CDD:395500	72/214 (34%)