Protein Alignment vari and mpp2b

DIOPT Version :10

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_005156123.1
• Gene: mpp2b / 431770
• ZFINID: ZDB-GENE-040704-70
• Length: 561
• Species: Danio rerio
• Alignment Length: 617
• Identity: 239/617 - (38%)
• Similarity: 343/617 - (55%)
• Gaps: 96/617 - (15%)

  Fly    30 DDTSDNAAFRNSTDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPLFLPA-HLNNKPICDD 93
            |..||:.   :||..:|.|.|||||::.|..:..|.|      ||:     |.| ..||..:..|
Zfish    31 DTLSDST---SSTTANDLDLIFLKGIMESPVSREHYE------EPK-----LEAVRDNNVELVQD 81

  Fly    94 IIRKF------SPSRRLESRELAKLLAQPHFRALLRAHDEIGA-LYEQRLKAAGGSTSQLEIASQ 151
            |:|..      ||:    :.||..:|.:|||::||..||.:.: .||                 .
Zfish    82 ILRDLNTLSPDSPA----AHELICILKEPHFQSLLETHDSVASKSYE-----------------T 125

  Fly   152 RQTGGYLFTEDVLNTK-MPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSML 215
            .......|.:...|.: :|.:.::|||:|:...:.||:|..: |..:||:||||.||:||:|.:|
Zfish   126 PPPSPCAFMDPAFNNQPVPPDAVRMVGIRKVSGEHLGVTFRV-EGGELVIARILHGGMIDQQGLL 189

  Fly   216 HVGDVILEVNGTPVRT-PDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLE 279
            ||||:|.||||..|.: |..||..:..:..::.|||.|:..|.     :|.....||
Zfish   190 HVGDIIKEVNGKEVGSDPKVLQNMLKESSGSVVLKILPSYQEP-----HTPRQAFVK-------- 241

  Fly   280 TGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIP 344
                  |:    |.|:||.|:|:||::.||.|.|||||||.|.:|||||||.::  |....||||
Zfish   242 ------CH----FDYDPSHDNLIPCKEAGLKFSSGDILQIFNQEDPNWWQACHL--EGGSAGLIP 294

  Fly   345 SQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRR 409
            ||.|||:|||||..:.:......:|.....|:|:|.||.:..|.|||:.||.:||||.|:|||||
Zfish   295 SQLLEEKRKAFVKRDLELASTGPLCAGIGGKKKKKMMYLTTKNAEFDRHELRIYEEVARVPPFRR 359

  Fly   410 KTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNE 474
            |||||||..|||||:|||:|:.||..::|...|:|||..:..|:.|..|.||.|.|||..::...
Zfish   360 KTLVLIGAQGVGRRSLKNKLLVSDPHRYGTTTPYTSRKPKVDEKEGQMYLFMSRSEMETDIKCGR 424

  Fly   475 FLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTI 539
            |||:||::||||||.:.||.:|::||::||||..|.|||:|..: |.:|:|:|:.||..|.||.:
Zfish   425 FLEHGEYDGNLYGTKIDSIHEVVDSGKICILDVNPQALKVLRTA-EFLPYVVFIEAPNFEVLKDM 488

  Fly   540 YADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVI 604
                                    :|.|.....:.....|.:|..||:||..:||.|..|||:.|
Zfish   489 ------------------------NRSAIEAGVVTKQMTDSELKRTVDESERIQRAYSHYFDLSI 529

  Fly   605 VNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            ||::.|..:|.:...||:::.::|||||:|::
Zfish   530 VNDNLDGAYRSLRRALDRLNTDQQWVPVSWVF 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:460717	10/22 (45%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	36/78 (46%)
		SH3_MPP	287..347	CDD:212796	32/59 (54%)
		Guanylate_kin	408..622	CDD:395500	88/213 (41%)
mpp2b	XP_005156123.1	L27	76..127	CDD:460717	17/71 (24%)
		PDZ_MPP6-MPP2-like	149..227	CDD:467268	36/78 (46%)
		SH3_MPP2	239..297	CDD:212970	35/77 (45%)
		Guanylate_kin	358..546	CDD:395500	87/212 (41%)