Protein Alignment vari and mpp2b

DIOPT Version :9

• Sequence 1: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_005156123.1
• Gene: mpp2b / 431770
• ZFINID: ZDB-GENE-040704-70
• Length: 561
• Species: Danio rerio
• Alignment Length: 617
• Identity: 239/617 - (38%)
• Similarity: 343/617 - (55%)
• Gaps: 96/617 - (15%)

  Fly    30 DDTSDNAAFRNSTDLSDHDEIFLKGLLRSNSNTPHKELMLNPTEPQPVPLFLPA-HLNNKPICDD 93
            |..||:.   :||..:|.|.|||||::.|..:..|.|      ||:     |.| ..||..:..|
Zfish    31 DTLSDST---SSTTANDLDLIFLKGIMESPVSREHYE------EPK-----LEAVRDNNVELVQD 81

  Fly    94 IIRKF------SPSRRLESRELAKLLAQPHFRALLRAHDEIGA-LYEQRLKAAGGSTSQLEIASQ 151
            |:|..      ||:    :.||..:|.:|||::||..||.:.: .||                 .
Zfish    82 ILRDLNTLSPDSPA----AHELICILKEPHFQSLLETHDSVASKSYE-----------------T 125

  Fly   152 RQTGGYLFTEDVLNTK-MPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVARILAGGVIDKQSML 215
            .......|.:...|.: :|.:.::|||:|:...:.||:|..: |..:||:||||.||:||:|.:|
Zfish   126 PPPSPCAFMDPAFNNQPVPPDAVRMVGIRKVSGEHLGVTFRV-EGGELVIARILHGGMIDQQGLL 189

  Fly   216 HVGDVILEVNGTPVRT-PDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSGGQVKQNGIASLE 279
            ||||:|.||||..|.: |..||..:..:..::.|||.|:..|.     :|.....||
Zfish   190 HVGDIIKEVNGKEVGSDPKVLQNMLKESSGSVVLKILPSYQEP-----HTPRQAFVK-------- 241

  Fly   280 TGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKNITAESDKIGLIP 344
                  |:    |.|:||.|:|:||::.||.|.|||||||.|.:|||||||.::  |....||||
Zfish   242 ------CH----FDYDPSHDNLIPCKEAGLKFSSGDILQIFNQEDPNWWQACHL--EGGSAGLIP 294

  Fly   345 SQELEERRKAFVAPEADYVHKIGICGTRISKRKRKTMYRSVANCEFDKAELLLYEEVTRMPPFRR 409
            ||.|||:|||||..:.:......:|.....|:|:|.||.:..|.|||:.||.:||||.|:|||||
Zfish   295 SQLLEEKRKAFVKRDLELASTGPLCAGIGGKKKKKMMYLTTKNAEFDRHELRIYEEVARVPPFRR 359

  Fly   410 KTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNE 474
            |||||||..|||||:|||:|:.||..::|...|:|||..:..|:.|..|.||.|.|||..::...
Zfish   360 KTLVLIGAQGVGRRSLKNKLLVSDPHRYGTTTPYTSRKPKVDEKEGQMYLFMSRSEMETDIKCGR 424

  Fly   475 FLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTI 539
            |||:||::||||||.:.||.:|::||::||||..|.|||:|..: |.:|:|:|:.||..|.||.:
Zfish   425 FLEHGEYDGNLYGTKIDSIHEVVDSGKICILDVNPQALKVLRTA-EFLPYVVFIEAPNFEVLKDM 488

  Fly   540 YADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVI 604
                                    :|.|.....:.....|.:|..||:||..:||.|..|||:.|
Zfish   489 ------------------------NRSAIEAGVVTKQMTDSELKRTVDESERIQRAYSHYFDLSI 529

  Fly   605 VNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
            ||::.|..:|.:...||:::.::|||||:|::
Zfish   530 VNDNLDGAYRSLRRALDRLNTDQQWVPVSWVF 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	10/22 (45%)
		PDZ_signaling	173..250	CDD:238492	34/77 (44%)
		SH3_MPP	287..347	CDD:212796	32/59 (54%)
		Guanylate_kin	408..622	CDD:279019	88/213 (41%)
		GuKc	418..622	CDD:214504	79/203 (39%)
mpp2b	XP_005156123.1	L27	76..127	CDD:280918	17/71 (24%)
		PDZ_signaling	148..226	CDD:238492	35/78 (45%)
		SH3_MPP2	239..297	CDD:212970	35/77 (45%)
		Guanylate_kin	358..546	CDD:279019	87/212 (41%)
		GuKc	368..546	CDD:214504	78/202 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594305
Domainoid	1	1.000	60	1.000	Domainoid score	I10546
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1911
OMA	1	1.010	-	-		QHG48629
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	1	1.000	-	-		FOG0003013
OrthoInspector	1	1.000	-	-		otm25584
orthoMCL	1	0.900	-	-		OOG6_104327
Panther	1	1.100	-	-	O	PTHR23122
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8457
SonicParanoid	1	1.000	-	-		X2005
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800