DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vari and CASK

DIOPT Version :9

Sequence 1:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	193/577 - (33%)
Similarity:	295/577 - (51%)	Gaps:	118/577 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 CDDIIRKFSPSR-------RLESRELAKLLAQPHFRALLRAHDEIGA-LY-EQRLKAA------- 139
            |.|::.:.|.:.       :....||.:|||.||.:|||.:||.:.. :| |:.|:..
  Fly   409 CRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVARDVYGEEALRVTPPPMVPY 473

  Fly   140 --GGSTSQLEIASQRQTGGYLFTEDVLNTKMPVETIKMVGLRRDPSKPLGLTVELDEFKQLVVAR 202
              |.....:|       ||.|         ..|..:::|..:::..:|:|:|:::.|..:.:|||
  Fly   474 LNGDELDNVE-------GGEL---------QHVTRVRLVQFQKNTDEPMGITLKMTEDGRCIVAR 522

  Fly   203 ILAGGVIDKQSMLHVGDVILEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNVDE-----EIKS 260
            |:.||:|.:|:.|||||.|.|:||.||  ::..:||..:..|:.::|.||.|:...     ||
  Fly   523 IMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPSYRSAPPPCEI-- 585

  Fly   261 GRYTVSGGQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDP 325
                                      ::||.|.|||.:|.|:||...|:.|:.|||||||:..|.
  Fly   586 --------------------------FVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDH 624

  Fly   326 NWWQAKNITAESDKIGLIPSQELEERRKAFVAPEADYVHKI--GICGTRISKRKRKTMYRSVANC 388
            :||||: :.......|||||.||:|.|.|....:.....::  .|.|.:  |::.:..|.:..|.
  Fly   625 HWWQAR-LDTVGGSAGLIPSPELQEWRIACQTVDKTKQEQVNCSIFGRK--KKQCRDKYLAKHNA 686

  Fly   389 EFDKAELLLYEEVTRM----PPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKR 449
            .||..:::.||||.::    |.|:||||||:|..|||||.:||.||:...||:...||||:||.:
  Fly   687 IFDTLDVVTYEEVVKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAK 751

  Fly   450 ALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKI 514
            ..||||.||:|:..:||...:..||:||||.|...:|||.|.:|:.:...|:|.|||..|.||||
  Fly   752 PEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKI 816

  Fly   515 LHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYED 579
            |..: |..|:|:|:|||.::.:    ||           :|            .:||.||
  Fly   817 LRTA-EFTPYVVFIAAPSLQNI----AD-----------YD------------GSLERLA----- 848

  Fly   580 DDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVPVNWIY 636
                   :||..:::.|..:||:.|||.|..||...:...:|::....|||||:|:|
  Fly   849 -------KESEMLRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLY 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vari	NP_724288.3	L27	<105..128	CDD:280918	12/22 (55%)
		PDZ_signaling	173..250	CDD:238492	28/78 (36%)
		SH3_MPP	287..347	CDD:212796	29/59 (49%)
		Guanylate_kin	408..622	CDD:279019	81/213 (38%)
		GuKc	418..622	CDD:214504	74/203 (36%)
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918
		L27	406..462	CDD:280918	17/52 (33%)
		PDZ_signaling	493..573	CDD:238492	29/79 (37%)
		SH3_CASK	586..646	CDD:213014	29/60 (48%)
		Guanylate_kin	710..883	CDD:279019	81/212 (38%)
		GuKc	720..883	CDD:214504	74/202 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468175
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D18711at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23122
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850